Extremely preterm born infants and long‐term neurodevelopmental outcomes

2019 ◽  
Vol 109 (7) ◽  
pp. 1499-1499
Author(s):  
Despina D. Briana ◽  
Ariadne Malamitsi‐Puchner
Keyword(s):  
Neurodevelopmental Outcomes ◽  
Extremely Preterm ◽  
Preterm Born

Extremely preterm born infants and long‐term neurodevelopmental outcomes reply to Despina Briana and Ariadne Malamitsi‐Puchner

2020 ◽  
Vol 109 (7) ◽  
pp. 1500-1501
Author(s):  
Mehreen Zaigham ◽  
Karin Källén ◽  
Karel Maršál ◽  
Per Olofsson
Keyword(s):  
Neurodevelopmental Outcomes ◽  
Extremely Preterm ◽  
Preterm Born

Extremely preterm infant with persistent peeling skin: X-linked ichthyosis imitates prematurity

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Brigitte Burcescu ◽  
Heather L. Brumberg ◽  
Shetal I. Shah
Keyword(s):  
Preterm Infant ◽  
Genetic Disorder ◽  
Steroid Sulfatase ◽  
Neurodevelopmental Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Surfactant Production ◽  
Age Of Diagnosis ◽  
Scaly Skin

Abstract Objectives X-linked ichthyosis (XLI) is a genetic disorder caused by a deficiency in steroid sulfatase, an enzyme which catalyzes a reaction in estrone synthesis. The disorder primarily manifests as dry, scaly skin which may be difficult to diagnose in extremely preterm infants, as the dermatological features may be falsely attributed to a normal variant of skin for this population. Case presentation In this case report, we describe a male with XLI, born at 24 weeks gestation, who had persistent dry, flaky and hyperpigmented skin. This case is notable for the age of diagnosis in an extremely premature infant; day of life 105. In addition, this infant experienced out of proportion bronchopulmonary symptoms that we postulate may be linked to the steroid sulfatase deficiency, as estrogen is a mediator of surfactant production. Conclusions This report underscores the need to potentially evaluate persistent dry, flaky skin in the preterm infant, as XLI may also impact long term neurodevelopmental outcomes.

scholarly journals Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment Following Early Erythropoietin Among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial

2021 ◽  
Vol 11 (10) ◽  
pp. 1360
Author(s):  
Janessa B. Law ◽  
Bryan A. Comstock ◽  
Todd L. Richards ◽  
Christopher M. Traudt ◽  
Thomas R. Wood ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Linear Models ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Neurodevelopmental Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Postmenstrual Age

We aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who underwent MRI with DTI at 36 weeks postmenstrual age were included. Neurodevelopmental outcomes were evaluated by Bayley Scales of Infant and Toddler Development (BSID-III). Generalized linear models were used to assess the association between DTI parameters and treatment group, and then with neurodevelopmental outcomes. A total of 101 placebo- and 93 Epo-treated infants underwent MRI. DTI white matter mean diffusivity (MD) was lower in placebo- compared to Epo-treated infants in the cingulate and occipital regions, and occipital white matter fractional isotropy (FA) was lower in infants born at 24–25 weeks vs. 26–27 weeks. These values were not associated with lower BSID-III scores. Certain decreases in clustering coefficients tended to have lower BSID-III scores. Consistent with the PENUT Trial findings, there was no effect on long-term neurodevelopment in Epo-treated infants even in the presence of microstructural changes identified by DTI.

scholarly journals Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110280
Author(s):  
Sujata P. Sarda ◽  
Grammati Sarri ◽  
Csaba Siffel
Keyword(s):  
Systematic Review ◽  
North America ◽  
Major Complication ◽  
Neurodevelopmental Outcomes ◽  
Extreme Prematurity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Neurodevelopmental Impairment ◽  
Extremely Preterm Birth

Objective Neurodevelopmental impairment (NDI) is a major complication of extreme prematurity. This systematic review was conducted to summarize the worldwide long-term prevalence of NDI associated with extreme prematurity. Methods Embase and MEDLINE databases were searched for epidemiologic and observational/real-world studies, published in English between 2011 and 2016, reporting long-term prevalence of NDI (occurring from 1 year) among extremely preterm infants born at gestational age (GA) ≤28 weeks. Results Of 2406 articles identified through searches, 69 met the protocol NDI definition (24 North America, 25 Europe, 20 Rest of World). Prevalence of any severity NDI in North America was 8%–59% at 18 months to 2 years, and 11%–37% at 2–5 years; prevalence of moderate NDI in Europe was 10%–13% at 18 months to 2 years, 3% at 2–5 years, and 9%–19% at ≥5 years; prevalence of any NDI in Rest of World was 15%–61% at 18 months to 2 years, and 42% at 2–5 years (no North America/Rest of World studies reported any NDI at ≥5 years). A trend toward higher prevalence of NDI with lower GA at birth was observed. Conclusions Extreme prematurity has a significant long-term worldwide impact on neurodevelopmental outcomes.

Predictors of long-term neurodevelopmental outcomes of children born extremely preterm

2021 ◽  
pp. 151482
Author(s):  
Alicia J Spittle ◽  
Deanne K Thompson ◽  
Joy E Olsen ◽  
Amanda Kwong ◽  
Karli Treyvaud
Keyword(s):  
Neurodevelopmental Outcomes ◽  
Extremely Preterm

Improving Feeding Outcomes in the NICU: Moving From Volume-Driven to Infant-Driven Feeding

2010 ◽  
Vol 19 (3) ◽  
pp. 68-74 ◽  
Author(s):  
Catherine S. Shaker
Keyword(s):  
Intensive Care Unit ◽  
Dynamic Systems ◽  
Neonatal Intensive Care ◽  
Well Being ◽  
Dynamic Systems Theory ◽  
Feeding Problems ◽  
Care Giving ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Current research on feeding outcomes after discharge from the neonatal intensive care unit (NICU) suggests a need to critically look at the early underpinnings of persistent feeding problems in extremely preterm infants. Concepts of dynamic systems theory and sensitive care-giving are used to describe the specialized needs of this fragile population related to the emergence of safe and successful feeding and swallowing. Focusing on the infant as a co-regulatory partner and embracing a framework of an infant-driven, versus volume-driven, feeding approach are highlighted as best supporting the preterm infant's developmental strivings and long-term well-being.

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