Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents

2019 ◽  
Vol 108 (7) ◽  
pp. 1295-1302 ◽  
Author(s):  
Nivea Fazanaro Marra ◽  
Maria Teresa Bechere Fernandes ◽  
Maria Edna Melo ◽  
Rodrigo Marques Cruz ◽  
Beatriz Helena Tess
Keyword(s):  
Insulin Resistance ◽  
Fasting Insulin ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

Insulin Resistance as a Diagnostic Criterion for Metabolically Healthy Obesity in Children

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ana Pilar Nso-Roca ◽  
Ernesto Cortés Castell ◽  
Francisco Carratalá Marco ◽  
Francisco Sánchez Ferrer
Keyword(s):  
Insulin Resistance ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy ◽  
Diagnostic Criterion ◽  
Obesity In Children

scholarly journals Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Britta Noebauer ◽  
Alexander Jais ◽  
Jelena Todoric ◽  
Klaus Gossens ◽  
Hedwig Sutterlüty-Fall ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Obese Patients ◽  
Metabolically Healthy Obesity ◽  
Naturally Occurring ◽  
Obesity And Diabetes ◽  
Inflammatory Processes ◽  
Experimental Approaches ◽  
Metabolically Healthy

Obesity is a major risk factor for several diseases including diabetes, heart disease, and some forms of cancer and due to its rapidly increasing prevalence it has become one of the biggest problems medicine is facing today. All the more surprising, a substantial percentage of obese patients are metabolically healthy when classified based on insulin resistance and systemic inflammation. Oxysterols are naturally occurring molecules that play important role in various metabolic and inflammatory processes and their levels are elevated in patients suffering from obesity and diabetes. 25-Hydroxycholesterol (25-OHC) is produced in cells from cholesterol by the enzyme cholesterol 25-hydroxylase (Ch25h) and is involved in lipid metabolism, inflammatory processes, and cell proliferation. Here, we investigated the role of hepatic Ch25h in the transition from metabolically healthy obesity to insulin resistance and diabetes. Using several different experimental approaches, we demonstrated the significance of Ch25h on the border of “healthy” and “diseased” states of obesity. Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin sensitivity and lowered HOMA-IR. Our data suggest that low hepatic Ch25h levels could be considered a risk marker for unhealthy obesity.

scholarly journals THE CHARACTERISTICS OF SECRETION OF ADIPONECTIN AND ITS RELATIONSHIP WITH PARTICULAR INDICESOF METABOLISM IN MALES OF ABLE-BODIED AGE IN CASE OF OBESITY

2017 ◽  
Vol 23 (6) ◽  
pp. 312-315
Author(s):  
Olga V. Karataeva
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Low Density Lipoproteins ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Metabolically Healthy Obesity ◽  
Significant Difference ◽  
Fasting Glycaemia ◽  
Metabolically Healthy ◽  
Degree Of Severity

The sampling consisted of 79 examined males of able-bodied age. The arterial hypertension stage I and II was established in 58% of them; obesity of various degree of severity was diagnosed in 63% of them; metabolic syndrome according criteria ATP-III was noted in 46.8% of examined patients. The general clinical and anthropometric examination was carried out. The laboratory analyses included estimation of lipidogram, fasting glycaemia and also hormones adiponectin and insulin with following calculation of index of insulin resistance HOMA-IR (Homeostasis Model Assessment of Insulin Resistance). The study was organized to investigate effecting of obesity on secretion of adiponectin and its relationship with indices of lipidogram and level of insulin resistance. The comparative analysis of groups with and absence of obesity established no significant difference in level of adiponectin and indices of lipidogram. the significant differences were established in the levels of basal insulin hence in value of index NOMA-IR that points to hyperinsulinemia and expressed insulin resistance in patients with obesity. The patients were separated in two groups depending on presence of manifestations of metabolic syndrome: with metabolically healthy obesity and metabolically complicated obesity. The analysis established a significant decreasing of level of adiponectin in the group of metabolically complicated obesity accompanied by insulin resistance, dyslipidemia and increased level of glycaemia. The study established no effect of degree of obesity on decreasing of level of adiponectin. The significant differences between levels of adiponectin in comparison between group without obesity and group of metabolically healthy obesity. The correlation analysis in group with obesity demonstrated back-coupling between level of adiponectin and content of total cholesterol, low density lipoproteins and coefficient of atherogenicity. The comparison of groups according median of adiponectin established significant differences in rate of development of metabolic syndrome and value of coefficient of atherogenicity.

scholarly journals Metabolically healthy obesity: predictors of transformation to unhealthy phenotype in St Petersburg population (according to the ESSE-RF study)

2021 ◽  
Vol 27 (3) ◽  
pp. 279-290
Author(s):  
M. A. Boyarinova ◽  
O. P. Rotar ◽  
A. M. Erina ◽  
N. A. Paskar ◽  
A. S. Alieva ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Waist Circumference ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy ◽  
Over Time

Objective. The purpose of the study was to determine the dynamics of the metabolically healthy obesity (MHO) status according to the Meigs criteria, and to establish the predictors of the transformation of healthy obesity phenotype into an unhealthy (MUHO) one in the population of residents of St Petersburg (Russia) at 6,5-year follow-up. Design and methods. Within the epidemiology study ESSE-RF a random sample of 1600 St Petersburg inhabitants stratified according to gender and age was formed. Examination of participants included anthropometry with measurement of waist circumference and calculation of body mass index (BMI), measurement of blood pressure (BP), fasting blood glucose, insulin (index of insulin resistance was calculated), creatinine, cortisol, lipid spectrum, C-reactive protein, adiponectin, leptin, and uric acid. Meigs MHO criteria (2006) were used in obese subjects (BMI > 30 kg/m²). Obese patients, who were identified as metabolically healthy in 2012–2013, were invited for follow-up in 2018–2019. Results. At the first stage obesity was diagnosed in 430 (26,9 %) participants, according to the BMI, 116 (27,0 %) of them were metabolically healthy according to the Meigs criteria. At follow-up, 44,4% individuals with the MHO phenotype transformed to the MUHO category on average after 6,5 years. Individuals who retained the MHO phenotype over time had significantly lower baseline systolic BP and diastolic BP levels, more favorable lipid levels and lower levels of uric acid, insulin, and index of insulin resistance. Glucose increase by every 0,5 mmol/l and higher was associated with elevated probability of transformation MHO to MUHO phenotype by 10,9 times (adjusted for sex and age). Conclusions. Significantly higher levels of BP, insulin resistance, low density lipoprotein and uric acid at baseline, as well as an increase in glucose levels over time, were associated with the transformation of the metabolically healthy to the unhealthy phenotype in obese individuals at 6,5-year follow-up. In all individuals with the MHO phenotype, there was a significant increase in waist circumference over time, accompanied by an increase in BMI only in those who transformed into the MUHO status.

scholarly journals Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population

2020 ◽  
Vol 17 (19) ◽  
pp. 6995
Author(s):  
Maria Isabel Ruiz-Moreno ◽  
Alberto Vilches-Perez ◽  
Cristina Gallardo-Escribano ◽  
Antonio Vargas-Candela ◽  
Maria Dolores Lopez-Carmona ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Hdl Cholesterol ◽  
Model Assessment ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Abdominal Perimeter ◽  
Metabolically Healthy

Aim: Arteriosclerotic cardiovascular disease, one of the world’s leading causes of death, first manifests itself at an early age. The identification of children who may have increased cardiovascular risk in the future could be an important prevention strategy. Our aim was to assess the clinical, analytical, and dietary variables associated with arterial stiffness (AS), measured by carotid-femoral pulse wave velocity (cfPWV) in a prepubescent population with metabolically healthy obesity (MHO). Subjects and Methods: A cross-sectional study in prepubescent subjects with obesity who had ≤1 metabolic syndrome criteria (abdominal perimeter and blood pressure ≥90th percentile, triglycerides >150 mg/dL, HDL-cholesterol <40 mg/dL, fasting plasma glucose ≥100 mg/dL) was conducted. Adherence to Mediterranean Diet, blood pressure, BMI, waist/height ratio (WHtR), glycemic status, lipid profile, and cfPWV were analyzed. 75 MHO children (boys: 43; girls: 32; p = 0.20) (age = 10.05 ± 1.29 years; BMI = 25.29 ± 3.5 kg/m2) were included. Results: We found a positive correlation between cfPWV and weight (r = 0.51; p < 0.0001), BMI (r = 0.44; p < 0.0001), WHtR (r = 0.26; p = 0.02), fasting insulin levels (r = 0.28; p = 0.02), and insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index) (r = 0.25; p = 0.04). Multiple linear regression analysis identified BMI and HOMA-IR as independent parameters associated with cfPWV. Conclusions: Prepubescent children with obesity who were shown to be metabolically healthy presented with arterial stiffness, which is closely related to BMI and the state of insulin resistance.

Insulin resistance persists despite a metabolically healthy obesity phenotype

Obesity ◽  
2021 ◽  
Author(s):  
Kristin K. Hoddy ◽  
Christopher L. Axelrod ◽  
Jacob T. Mey ◽  
Adithya Hari ◽  
Robbie A. Beyl ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolically Healthy Obesity ◽  
Obesity Phenotype ◽  
Metabolically Healthy

scholarly journals Circulating prolactin level is increased in metabolically healthy obesity

2021 ◽  
Vol 10 (4) ◽  
pp. 484-491
Author(s):  
Jia Liu ◽  
Lin Zhang ◽  
Jing Fu ◽  
Qiu Wang ◽  
Guang Wang
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Energy Metabolism ◽  
Logistic Regression Analysis ◽  
Multivariable Logistic Regression Analysis ◽  
Multivariate Linear Regression Analysis ◽  
Metabolically Healthy Obesity ◽  
Multivariable Logistic Regression ◽  
Metabolically Healthy

Objective Prolactin (PRL) has been demonstrated as a metabolic hormone to regulate energy metabolism recently. The present study aims to investigate the association between PRL and metabolic alterations in different obesity phenotypes. Methods A total of 451 drug-naive participants were recruited, comprising 351 obese patients and 100 age- and sex-matched healthy participants with normal weight. PRL, anthropometric, and clinical parameters were measured. Results In the obesity group, 15.1% (53/351) were categorized as 'metabolically healthy obesity (MHO)'. Besides favorable blood pressure, glucose, and lipids profiles, the MHO group exhibited increased PRL, and lower levels of high-sensitivity C-reactive protein (hsCRP), homeostasis model assessment of insulin resistance (HOMA-IR), and adipose tissue insulin resistance (adipo-IR) than the metabolically unhealthy obesity (MUHO) group (PRL, HOMA-IR, and adipo-IR: P < 0.01; hsCRP: P < 0.05). The severe MUHO group showed significantly decreased PRL levels than the mild MUHO group (P < 0.05). Multivariate linear regression analysis indicated that fasting plasma glucose (FBG) and adipo-IR were significantly associated with PRL (FBG: β = −0.263, P < 0.05; adipo-IR: β = −0.464, P < 0.01). Multivariable logistic regression analysis showed that hsCRP (OR = 0.824) and PRL (OR = 1.211) were independent predictors of MHO (all P < 0.01). Conclusion The MHO group had significantly increased circulating PRL levels when compared with the control and MUHO groups, and multivariable logistic regression analysis showed that PRL was independent predictors of MHO. Our findings suggested that increased circulating PRL might be a compensatory response for favoring energy metabolism during obesity.

scholarly journals AB0306 OBESITY PHENOTYPES IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1179.1-1179
Author(s):  
L. Kondrateva ◽  
T. Panafidina ◽  
T. Popkova ◽  
M. Cherkasova ◽  
A. Lila ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Insulin Resistance ◽  
Lupus Erythematosus ◽  
Metabolic Disorders ◽  
Disease Duration ◽  
Normal Weight ◽  
Metabolically Healthy Obesity ◽  
Systemic Lupus ◽  
Serum Leptin ◽  
Metabolically Healthy

Background:The so-called “obesity paradox” when cardiovascular risk is lower in overweight compared to lean patients accompanies some chronic conditions. A possible explanation for this phenomenon comes from variability of obesity phenotypes, i.e., “classical” obesity as exemplary perception of obesity is equal to increased body mass index (BMI) and metabolic disorders; but there are also “metabolically healthy” overweight individuals (increased BMI without metabolic disorders), and “latent” obesity phenomenon (when normal weight is associated with metabolic disorders, especially with insulin resistance (IR) and adipocytokines imbalance). Serum leptin concentrations increase has been established in obese, therefore, this adipocytokine synthesized in adipose tissue, can be used as a marker of body fat mass. Higher cardiovascular risks are known even in young patients with systemic lupus erythematosus (SLE), but obesity phenotypes have not been studied.Objectives:To find out the rate of various obesity phenotypes and to identify factors contributing to “latent” obesity in SLE pts without diabetes mellitus (DM) or hyperglycemia.Methods:A total of 49 SLE pts (46 women, 3 men, 40 [33;48] years old) without established DM or hyperglycemia were enrolled in the study. The median disease duration was 3,0[0,7;8,0] years, SLEDAI-2K was 5[2;8]. SLE pts were treated with glucocorticoids (GC) (84%) and hydroxychloroquine (78%), immunosuppressive drugs (20%) and biological agents (10%). Insulin levels were measured using electrochemiluminescence assay Elecsys (Roche Diagnostics), serum leptin concentrations were estimated using ELISA (DBS-Diagnostics Biochem Canada Inc.). IR was defined as Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) ≥2,77. Leptin levels were considered elevated at values ≥11,1 ng/ml for women, ≥5.6 ng/ml for men. The overweight / obesity status was determined by World Health Organization criteria in patients with body mass index (BMI) ≥25kg/m2.Results:Overweight / obesity were established in 45% of pts, normal BMI was in 55% of SLE pts. The combination of IR and high leptin levels was found in 32% of overweight / obese pts and 11% of pts with normal BMI (p=0,2), an isolated increased leptin levels - in 64% and 41%, respectively (p=0,1). Metabolic disturbances were absent in 4% of overweight pts and 48% of pts with a normal BMI (p=0,001). Thus, “classical” obesity was found in 43% of cases, “metabolically healthy” obesity - in 2%, and “latent” obesity - in 29% of SLE pts. Leptin levels correlated with BMI (r=0,5, p=0,02), waist circumference (r=0,5, p=0,02) in the overweight / obesity group, and with disease duration (r=0,5, p=0,02), SLEDAI-2K (r=-0,6, p=0,002), anti-dsDNA (r=-0,7, p<0,001), C3 complement (r=0,5, p=0,01), maximum (r=0,7, p<0,001) and current GCs doses (r=0,4, p=0,03) in patients with normal weight. There was a trend to association between leptin levels and duration of GCs therapy in SLE pts with normal BMI (r=0,4, p=0,06).Conclusion:Metabolic disorders - most often increased leptin levels - were diagnosed in the majority of overweight / obese patients, as well as in about 50% of SLE patients with normal weight. There were only isolated cases of “metabolically healthy” obesity in SLE patients. Metabolically obese normal weight (“latent” obesity) phenotype was strongly associated with GCs therapy and decreased disease activity.Disclosure of Interests:None declared

Therapeutic Effect of Metformin and Vitamin E Versus Prescriptive Diet in Obese Adolescents with Fatty Liver

2011 ◽  
Vol 81 (6) ◽  
pp. 398-406 ◽  
Author(s):  
Akcam ◽  
Boyaci ◽  
Pirgon ◽  
Kaya ◽  
Uysal ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin E ◽  
Fatty Liver ◽  
Liver Steatosis ◽  
Tnf Alpha ◽  
Dietary Advice ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Alcoholic Fatty Liver ◽  
Obese Adolescents

Objective: The aim of the study was to determine whether metformin or vitamin E treatment for six months is effective in reducing body weight, blood pressure, and also ameliorating insulin resistance, adiponectin, and tumor necrosis factor (TNF)-alpha in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty-seven obese adolescents with liver steatosis (age range, 9 - 17 years) were included in the study. The metformin group received an 850-mg dose of metformin daily and the vitamin E group received 400 U vitamin E /daily, in capsule form for 6 months, plus an individually tailored diet, exercise, and behavioral therapy. Results: After 6 months later, there was a significant decline in body mass index, and fasting insulin and homeostatic model assessment (HOMA) values in all three groups. Moreover, in comparingson of changes in HOMA among the groups, the metformin- treated group showed significantly improved metabolic control and insulin sensitivity (HOMA) at the end of the study. There were no significant differences for changes of adiponectin, TNF-alpha, in all three groups after 6 months study. Conclusion: These data suggest that metformin treatment is more effective than dietary advice and vitamin E treatment in reducing insulin resistance, and also in ameliorating metabolic parameters such as fasting insulin and lipid levels, in obese adolescents having NAFLD.

Sign in / Sign up

Export Citation Format

Share Document