High birth weight was associated with increased radial artery intima thickness but not with other investigated cardiovascular risk factors in adulthood

2018 ◽  
Vol 107 (12) ◽  
pp. 2152-2157 ◽  
Author(s):  
I W Johnsson ◽  
T Naessén ◽  
F Ahlsson ◽  
J Gustafsson
2018 ◽  
Vol 72 (4) ◽  
pp. 272-278 ◽  
Author(s):  
Daniel L. Ledo ◽  
Fabíola Isabel Suano-Souza ◽  
Maria do Carmo P. Franco ◽  
Maria Wany L. Strufaldi

Background/Aims: This study aimed to identify a possible association among high birth weight with overweight/obesity, high arterial blood pressure, dyslipidemia, and insulin resistance in children and adolescents. Methods: This is a cross-sectional study with 719 children and adolescents (6–12 years) stratified according to birth weight (low birth weight [LBW] <2,500 g, adequate birth weight [ABW] 2,500–3,999 g, and high birth weight [HBW] ≥4,000 g). Data collected were anthropometric data, arterial blood pressure levels, lipid profile, and insulin resistance (fasting glucose and insulin, used to calculate homeostatic model assessment-IR). Results: The mean age of schoolchildren was 9.5 ± 2.0 years and 371 (51.6%) were male. LBW and HBW were observed in 79 of 719 (10.9%) and 40 of 719 (55.6%) children/adolescents, respectively. There was no increased risk of overweight (OR 0.9; 95% CI 0.4–2.1; p = 0.964) and obesity (OR 1.4; 95% CI 0.6–3.5; p = 0.588) in HBW group compared to LBW and ABW groups. HBW was not associated with high blood pressure, dyslipidemia, and insulin resistance. The LBW group was independently associated with higher values of systolic (OR 1.07; 95% CI 1.05–1.10; p < 0.01) and diastolic blood pressure (OR 1.04; 95% CI 1.00–1.07; p = 0.044). Conclusion: There was no association between HBW with overweight/obesity and classic cardiovascular risk factors in this group of children/adolescents. Only LBW was related to higher blood pressure levels.


2012 ◽  
Vol 3 (6) ◽  
pp. 458-468 ◽  
Author(s):  
A. Shrivastava ◽  
C. Murrin ◽  
J. O'Brien ◽  
K. Viljoen ◽  
P. Heavey ◽  
...  

The association of infants’ birth weight with maternal cardiovascular morbidity (CVD) and mortality substantiates the foetal origins hypothesis. Few studies to date have investigated grandparent–infant risk association. We prospectively examined this relationship in the Lifeways three-generation familial cohort, contrasting lineage and gender differences to understand mechanisms of intergenerational risk transmission. In 2001, a cohort of 1082 families was established at antenatal stage. A total of 539 families (n = 539 infants) had both a participating grandparent (n = 1054) and information on infants’ gestational age. At baseline, grandparents provided their diagnosed CVD status and 79% also underwent a cardiovascular risk factors assessment. In 2005, general practitioners provided an update for 61% grandparents. In 2010, a search of civil register confirmed 77 grandparental deaths in 539 families. Grandchildren's birth weight and grandparental cardiovascular risk factors associations were examined with linear regressions. Grandparental CVD associations were analysed using ANCOVA. Cox proportional hazard ratios (HR) were calculated for all-cause mortality associations. Models were adjusted for infants’, mothers’ and grandparents’ demographic, anthropometric and socio-behavioural characteristics, as appropriate. The paternal grandfathers’ (PGF) systolic blood pressure (mmHg) [β (95% CI) = 6.6 (0.8 – 12.5); P = 0.03] and paternal grandmothers’ serum triglycerides (mmol/l) [β (95% CI) = 78.8 (7.0 – 150.7); P = 0.03] were linearly predictive of infants’ birth weight, which was not observed for maternal grandparents. Mean birth weight for infants of maternal grandmothers with diabetes {−272.7 [(−499.7) − (−45.6)] g; P = 0.02} or stroke {−292.1 [(−544.5) − (−39.6)] g; P = 0.02} was lower than those without diabetes or stroke, a pattern not observed for paternal grandparents. Whereas PGFs’ mortality was significantly associated with infants’ high birth weight (⩾4000 g) [HR (95% CI) = 4.9 (1.2 – 19.9); P = 0.03], maternal grandparents’ mortality showed a converse pattern with infants’ low birth weight (<2500 g) [HR (95% CI) = 1.7 (0.4 – 8.2); P = 0.7], although not statistically significant. These findings suggest that intergenerational transmission of risk differs in maternal and paternal lines.


2004 ◽  
Vol 255 (2) ◽  
pp. 236-246 ◽  
Author(s):  
M. Eriksson ◽  
M.-A. Wallander ◽  
I. Krakau ◽  
H. Wedel ◽  
K. Svardsudd

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20595 ◽  
Author(s):  
Signe Fabricius-Bjerre ◽  
Rikke Beck Jensen ◽  
Kristine Færch ◽  
Torben Larsen ◽  
Christian Mølgaard ◽  
...  

Obesity ◽  
2007 ◽  
Vol 15 (6) ◽  
pp. 1609-1616 ◽  
Author(s):  
Jung-Nan Wei ◽  
Hung-Yuan Li ◽  
Fung-Chang Sung ◽  
Chau-Ching Lin ◽  
Chuan-Chi Chiang ◽  
...  

2008 ◽  
Vol 63 (4) ◽  
pp. 214-215
Author(s):  
Pål R. Romundstad ◽  
George Davey Smith ◽  
Tom I. L. Nilsen ◽  
Lars J. Vatten

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