National cross-sectional study of nonsteroidal anti-inflammatory drugs use highlights differences between parents and professionals and prompts safety concerns

2016 ◽  
Vol 105 (11) ◽  
pp. e543-e548 ◽  
Author(s):  
Nathalie Bertille ◽  
Gérard Pons ◽  
Elisabeth Fournier-Charrière ◽  
Babak Khoshnood ◽  
Martin Chalumeau
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Safety Concerns ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

2019 ◽  
Author(s):  
Nuru Abdu ◽  
Samuel Teweldemedhin ◽  
Asmerom Mosazghi ◽  
Luwam Asfaha ◽  
Makda Teshale ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Interactions ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Protective Agents ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

scholarly journals Non-Steroidal Anti-Inflammatory Drugs in Orthopedic Outpatient Cases in a Tertiary Care Teaching Hospital: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (243) ◽  
pp. 1116-1119
Author(s):  
Aashish Bhattarai ◽  
Anna Acharya ◽  
Krishna Raj Khanal
Keyword(s):  
Confidence Interval ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Outpatient Department ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Introduction: Non-steroidal anti-inflammatory drugs are major drugs in treatment of pain and inflammation of different orthopedic conditions. There are different classes of non-steroidal anti-Inflammatory Drugs based on their selectivity to cyclooxygenase enzyme which has significant differences in safety profile. This study aims to determine the prevalence of non-steroidal anti-inflammatory drugs prescription in the orthopaedic outpatient department of a tertiary care hospital. Methods: This was a descriptive cross-sectional study conducted among the patients in the orthopedic outpatient department of tertiary care hospital from December 2020 to March 2021. Ethical approval was taken from the Institutional Review Committee of the college (Ref: 0311202007). Convenient sampling was done. A structured proforma was used with consent. The data were analyzed with Social Statistical Package for the Social Sciences version 20. Point estimate at 95% Confidence Interval was done and frequency and percentage were calculated. Results: Out of 140 orthopaedic out patient department prescriptions screened, 118 (84.28%) (78.25-90.30 at 95% Confidence Interval) prescriptions included non-steroidal anti-inflammatory drugs. Aceclofenac 76 (64.4%) was the most prescribed non-steroidal anti-inflammatory drug. Conclusions: Aceclofenac was the most preferred agent for the treatment in the department of orthopedics. The most common proton pump inhibitor used alone with non-steroidal anti-inflammatory drugs was rabeprazole.

scholarly journals Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0238868
Author(s):  
Nuru Abdu ◽  
Asmerom Mosazghi ◽  
Samuel Teweldemedhin ◽  
Luwam Asfaha ◽  
Makda Teshale ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional study

2014 ◽  
Vol 64 (621) ◽  
pp. e191-e198 ◽  
Author(s):  
Aafke R Koffeman ◽  
Vera E Valkhoff ◽  
Sevde Çelik ◽  
Geert W ’t Jong ◽  
Miriam CJM Sturkenboom ◽  
...  
Keyword(s):  
High Risk ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Over The Counter ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

2021 ◽  
Vol 10 (4) ◽  
pp. e44210414250
Author(s):  
Beatriz da Silva Santos ◽  
Manoela Santos da Silva ◽  
Isadora Oliveira e Pereira ◽  
Lucas Brasileiro Lemos ◽  
Gisele da Silveira Lemos
Keyword(s):  
Drug Interactions ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Electronic Prescription ◽  
Cross Sectional ◽  
Version 2.0 ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
A Chain

This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.

scholarly journals Myocarditis and Pericarditis Following mRNA COVID-19 Vaccination: What Do We Know So Far?

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 607
Author(s):  
Bibhuti B. Das ◽  
William B. Moskowitz ◽  
Mary B. Taylor ◽  
April Palmer
Keyword(s):  
Symptomatic Relief ◽  
Cross Sectional Study ◽  
Cardiac Complications ◽  
Sectional Study ◽  
Elevated Troponin ◽  
Resonance Imaging ◽  
Gadolinium Enhancement ◽  
Bottom Line ◽  
Cross Sectional ◽  
Inflammatory Drugs

This is a cross-sectional study of 29 published cases of acute myopericarditis following COVID-19 mRNA vaccination. The most common presentation was chest pain within 1–5 days after the second dose of mRNA COVID-19 vaccination. All patients had an elevated troponin. Cardiac magnetic resonance imaging revealed late gadolinium enhancement consistent with myocarditis in 69% of cases. All patients recovered clinically rapidly within 1–3 weeks. Most patients were treated with non-steroidal anti-inflammatory drugs for symptomatic relief, and 4 received intravenous immune globulin and corticosteroids. We speculate a possible causal relationship between vaccine administration and myocarditis. The data from our analysis confirms that all myocarditis and pericarditis cases are mild and resolve within a few days to few weeks. The bottom line is that the risk of cardiac complications among children and adults due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection far exceeds the minimal and rare risks of vaccination-related transient myocardial or pericardial inflammation.

Sign in / Sign up

Export Citation Format

Share Document