Protein tyrosine phosphatases receptor type D is a potential tumour suppressor gene inactivated by deoxyribonucleic acid methylation in paediatric acute myeloid leukaemia

2016 ◽  
Vol 105 (3) ◽  
pp. e132-e141 ◽  
Author(s):  
Lei Song ◽  
Wen Jiang ◽  
Wei Liu ◽  
Ju‐Hua Ji ◽  
Tai‐Feng Shi ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Deoxyribonucleic Acid ◽  
Protein Tyrosine Phosphatases ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Type D ◽  
Acute Myeloid

scholarly journals HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation

2008 ◽  
Vol 141 (2) ◽  
pp. 179-187 ◽  
Author(s):  
Christian Britschgi ◽  
Mathias Jenal ◽  
Mattia Rizzi ◽  
Beatrice U. Mueller ◽  
Bruce E. Torbett ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Granulocytic Differentiation ◽  
Acute Myeloid

scholarly journals Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling

2018 ◽  
Vol 19 (9) ◽  
pp. 2708 ◽  
Author(s):  
Mihwa Kim ◽  
Liza Morales ◽  
Ik-Soon Jang ◽  
Yong-Yeon Cho ◽  
Dae Kim
Keyword(s):  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Cellular Processes ◽  
Type D ◽  
Stat3 Signaling ◽  
Extracellular Stimuli ◽  
Src Homology ◽  
Cell Growth And Proliferation

The signal transducer and activator of transcription 3 (STAT3) protein is a major transcription factor involved in many cellular processes, such as cell growth and proliferation, differentiation, migration, and cell death or cell apoptosis. It is activated in response to a variety of extracellular stimuli including cytokines and growth factors. The aberrant activation of STAT3 contributes to several human diseases, particularly cancer. Consequently, STAT3-mediated signaling continues to be extensively studied in order to identify potential targets for the development of new and more effective clinical therapeutics. STAT3 activation can be regulated, either positively or negatively, by different posttranslational mechanisms including serine or tyrosine phosphorylation/dephosphorylation, acetylation, or demethylation. One of the major mechanisms that negatively regulates STAT3 activation is dephosphorylation of the tyrosine residue essential for its activation by protein tyrosine phosphatases (PTPs). There are seven PTPs that have been shown to dephosphorylate STAT3 and, thereby, regulate STAT3 signaling: PTP receptor-type D (PTPRD), PTP receptor-type T (PTPRT), PTP receptor-type K (PTPRK), Src homology region 2 (SH-2) domain-containing phosphatase 1(SHP1), SH-2 domain-containing phosphatase 2 (SHP2), MEG2/PTP non-receptor type 9 (PTPN9), and T-cell PTP (TC-PTP)/PTP non-receptor type 2 (PTPN2). These regulators have great potential as targets for the development of more effective therapies against human disease, including cancer.

The acute myeloid leukaemia market

2019 ◽  
Vol 19 (4) ◽  
pp. 233-234
Author(s):  
Jorrit Schaefer ◽  
Sorcha Cassidy ◽  
Rachel M. Webster
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Myeloid
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