scholarly journals Age‐related changes in the fractal dimension of the retinal microvasculature, effects of cardiovascular risk factors and smoking behaviour

2021 ◽  
Author(s):  
Sophie Lemmens ◽  
Martial Luyts ◽  
Nele Gerrits ◽  
Anna Ivanova ◽  
Charlien Landtmeeters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fractal Dimension ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Smoking Behaviour ◽  
Age Related ◽  
Retinal Microvasculature ◽  
Age Related Changes

scholarly journals Long-term effects of a food pattern on cardiovascular risk factors and age-related changes of muscular and cognitive function

Medicine ◽  
2020 ◽  
Vol 99 (39) ◽  
pp. e22381
Author(s):  
Charlotte Wernicke ◽  
Konstantina Apostolopoulou ◽  
Silke Hornemann ◽  
Andriana Efthymiou ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Cardiovascular Risk Factors ◽  
Long Term Effects ◽  
Food Pattern ◽  
Age Related ◽  
Age Related Changes

Association of plaque echostructure and cardiovascular risk factors with symptomatic carotid artery disease

VASA ◽  
2009 ◽  
Vol 38 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Giannoukas ◽  
Sfyroeras ◽  
Griffin ◽  
Saleptsis ◽  
Antoniou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Cardiovascular Risk Factors ◽  
Carotid Plaque ◽  
Young Patients ◽  
Symptomatic Disease ◽  
Age Related ◽  
Ica Stenosis

Background: Severity of stenosis remains the main factor for assessing risk of stroke in patients with internal carotid artery (ICA) disease. This study was conducted to investigate the association of plaque echostructure and other established and emerging cardiovascular risk factors with symptomatic ICA disease. Design: Cross-sectional study of consecutive patients with significant (> 50 %) ICA stenosis. Patients and methods: Carotid plaque echostructure, smoking, hypertension, diabetes mellitus, serum lipoprotein (a), homocysteine, vitamin B12, folate, cholesterol to high-density lipoprotein ratio, triglycerides, C-reactive protein, and the Framingham risk score were assessed in 124 consecutive patients (70 asymptomatic; 54 symptomatic) with significant (> 50 %) ICA stenosis. Results: The asymptomatic and symptomatic groups did not differ in terms of gender distribution (p = 0.76) and severity of stenosis (p = 0.62). Echolucent plaques (type 1 and 2) were more predominant in patients with symptomatic disease (p = 0.004, OR = 2.13, 95 % CI = 1.26-3.6). Patients with plaques type 1 were relatively younger than those with type 4 (p = 0.02). None of the other factors assessed had any significant association with symptomatic disease and any type of carotid plaque. Conclusions: Besides the severity of carotid stenosis, the presence of an echolucent plaque appears as an important factor associated with symptomatic ICA disease. Also, young patients are more likely to have an echolucent plaque suggesting an age-related association with plaque maturation.

Can the retinal microvasculature offer clues to cardiovascular risk factors in early life?

2013 ◽  
Vol 102 (10) ◽  
pp. 941-946 ◽  
Author(s):  
Ling-Jun Li ◽  
Yung-Seng Lee ◽  
Tien-Yin Wong ◽  
Carol Yim-Lui Cheung
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Early Life ◽  
Retinal Microvasculature

scholarly journals Impaired Oxidative Status Is Strongly Associated with Cardiovascular Risk Factors

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
E. Brunelli ◽  
D. La Russa ◽  
D. Pellegrino
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Oxidative Status ◽  
Healthy Population ◽  
Total Plasma ◽  
Oxidative Stress Biomarkers ◽  
Age Related ◽  
Modifiable Factors ◽  
Plasma Antioxidant

The main target of primary prevention is the identification of cardiovascular risk factors aimed at reducing of the adverse impact of modifiable factors, such as lifestyle and pharmacological treatments. In humans, an alteration of the oxidative status has been associated with several pathologies, including diabetes and cardiovascular diseases. However, the prognostic relevance of circulating oxidative stress biomarkers remains poorly understood. Our study explored, in a healthy population (n=322), the relationship between oxidative status and cardiovascular risk factors. Here, we were successful in demonstrating that plasmatic oxidative status is significantly associated with traditional cardiovascular risk factors. We revealed a significant depletion in the efficacy of total plasma antioxidant barrier in high cardiovascular risk categories, and we confirmed an age-related alteration of oxidative status. The efficacy of total plasma antioxidant barrier is significantly depleted in relation to metabolic disorders. Interestingly, the cholesterol imbalance is the main factor in depleting the efficacy of total plasma antioxidant barrier. The oxidative status is also influenced by hypertension, and a slight increase in systolic blood pressure determines a highly significant effect. We showed that the first detectable event of a redox disturbance is the repairing intervention of the antioxidant barrier that is thus decreased as overutilized.

scholarly journals Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study

2018 ◽  
Vol 3 (1) ◽  
pp. 291-303 ◽  
Author(s):  
Monik C Jiménez ◽  
Katherine L Tucker ◽  
Fátima Rodriguez ◽  
Bianca C Porneala ◽  
James B Meigs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Puerto Rican ◽  
Dehydroepiandrosterone Sulfate ◽  
Health Study ◽  
High Risk Population ◽  
Cvd Risk ◽  
Age Related

Abstract Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (β = −12.4; 95% CI: −15.2, −9.7; per 5 years), being female (vs. male) (β = −46; 95% CI: −55.3, −36.6), and plasma triglyceride concentration (β = −0.2; 95% CI: −0.3, −0.1; per 10 mg/dL) and was positively associated with total cholesterol and plasma glucose levels (β = 1.8; 95% CI: 0.6, 3 and β = 0.2; 95% CI: 0.04, 0.3, respectively, per 10 mg/dL) after adjustment for smoking, alcohol, and physical activity and for postmenopausal hormone use in women. Estimates were unchanged after adjustment for measures of chronic disease and inflammation. Women exhibited a stronger age-related decline in DHEAS and a positive association with glucose in contrast to findings among men (Pinteraction < 0.05). In conclusion, in this large study of Latinos with a heavy cardiovascular risk factor burden, we observed significant associations between cardiovascular disease (CVD) risk factors and DHEAS, with variations by sex. These findings improve our understanding of the role DHEAS may play in CVD etiology.

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