Epidemiology of uveal melanomas in Germany

2021 ◽  
Author(s):  
Joel M. Mor ◽  
Alexander C. Rokohl ◽  
Stefan Dahm ◽  
Klaus Kraywinkel ◽  
Ludwig M. Heindl
Keyword(s):  
Uveal Melanomas

Gamma knife radiosurgery for uveal melanomas: an 8-year experience

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 184-188 ◽  
Author(s):  
Gerald Langmann ◽  
Gerhard Pendl ◽  
Georg Papaefthymiou ◽  
Helmuth Guss ◽  
Keyword(s):  
Gamma Knife ◽  
Ciliary Body ◽  
Tumor Regression ◽  
Gamma Knife Radiosurgery ◽  
Neovascular Glaucoma ◽  
Content Type ◽  
Prescription Dose ◽  
The Mean ◽  
Fine Print ◽  
Uveal Melanomas

Object. The authors report their experience using gamma knife radiosurgery (GKS) to treat uveal melanomas. Methods. Between 1992 and 1998, 60 patients were treated with GKS at a prescription dose between 45 Gy and 80 Gy. The mean diameter of the tumor base was 12.2 mm (range 3–22 mm). The mean height of the tumor prominence was 6.7 mm (range 3–12 mm). The eye was immobilized. The follow-up period ranged from 16 to 94 months. Tumor regression was achieved in 56 (93%) of 60 patients. There were four recurrences followed by enucleation. The severe side effect of neovascular glaucoma developed in 21 (35%) patients in a high-dose group with larger tumors and in proximity to the ciliary body. A reduction in the prescription dose to 40 Gy or less and excluding treatment to tumors near the ciliary body decreased the rate of glaucoma without affecting the rate of tumor control. Conclusions. Gamma knife radiosurgery at a prescription dose of 45 Gy or more can achieve tumor regression in 85% of the uveal melanomas treated. Neovascular glaucoma can develop in patients when using this dose in tumors near the ciliary body. It is advised that such tumors be avoided and that the prescription dose be reduced to 40 Gy.

Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology

2021 ◽  
pp. 100968
Author(s):  
Thomas Strub ◽  
Arnaud Martel ◽  
Sacha Nahon-Esteve ◽  
Stéphanie Baillif ◽  
Robert Ballotti ◽  
...  
Keyword(s):  
Single Cell ◽  
Clinical Oncology ◽  
Transcriptomic Analysis ◽  
Uveal Melanomas

scholarly journals 543 The high expression of pro-apoptotic BCL2 family members in uveal melanomas contribute to their sensitivity to MCL1 inhibitors

2021 ◽  
Vol 141 (5) ◽  
pp. S94
Author(s):  
N. Mukherjee ◽  
C. Dart ◽  
C. Amato ◽  
J. Skees ◽  
A. Honig-Frand ◽  
...  
Keyword(s):  
Family Members ◽  
High Expression ◽  
Bcl2 Family ◽  
Uveal Melanomas

scholarly journals Small High-Risk Uveal Melanomas Have a Lower Mortality Rate

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2267
Author(s):  
Rumana N. Hussain ◽  
Sarah E. Coupland ◽  
Helen Kalirai ◽  
Azzam F. G. Taktak ◽  
Antonio Eleuteri ◽  
...  
Keyword(s):  
High Risk ◽  
Lead Time ◽  
Absolute Risk ◽  
Hazard Rates ◽  
Watch And Wait ◽  
Tumor Group ◽  
Monosomy 3 ◽  
The Difference ◽  
Oncology Centre ◽  
Uveal Melanomas

Our aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We undertook a retrospective analysis of data from a patient cohort with genetically characterized UM. All patients treated for UM in the Liverpool Ocular Oncology Centre between 2007 and 2014, who had a prognostic genetic tumor analysis. Patients were subdivided into those with small (≤2.5 mm thickness) and large (>2.5 mm thickness) tumors. Survival analyses were performed using Gray rank statistics to calculate absolute probabilities of dying as a result of metastatic UM. The 5-year absolute risk of metastatic mortality of those with small monosomy 3 UM was significantly lower (23%) compared to the larger tumor group (50%) (p = 0.003). Small disomy 3 UM also had a lower absolute risk of metastatic mortality (0.8%) than large disomy 3 UM (6.4%) (p = 0.007). Hazard rates showed similar differences even with lead time bias correction estimates. We therefore conclude that earlier treatment of all small UM, particularly monosomy 3 UM, reduces the risk of metastatic disease and death. Our results would support molecular studies of even small UM, rather than ‘watch-and-wait strategies’.

scholarly journals T2 Fluid-Attenuated Inversion Recovery Imaging of Uveal Melanomas and Other Ocular Pathology

2016 ◽  
Vol 2 (4) ◽  
pp. 251-261 ◽  
Author(s):  
Gena M. Damento ◽  
Kelly K. Koeller ◽  
Diva R. Salomão ◽  
Jose S. Pulido
Keyword(s):  
Inversion Recovery ◽  
Ocular Pathology ◽  
Inversion Recovery Imaging ◽  
Fluid Attenuated Inversion Recovery ◽  
Uveal Melanomas

103Pd Versus 125I Plaque Radiation Dose to Normal Ocular Structures in the Treatment of 319 Uveal Melanomas

2013 ◽  
Vol 87 (2) ◽  
pp. S268-S269
Author(s):  
D. Zhou ◽  
E. Semenova ◽  
P. Wong ◽  
N. Kalach ◽  
W. Choi ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Uveal Melanomas

scholarly journals Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matrices

2009 ◽  
Vol 136 (4) ◽  
pp. 577-586 ◽  
Author(s):  
Sebastian Di Cesare ◽  
Andre Nantel ◽  
Jean-Claude Marshall ◽  
Bruno F. Fernandes ◽  
Emilia Antecka ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed ◽  
Uveal Melanomas
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