Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes

2021 ◽  
Author(s):  
Olena Fedotkina ◽  
Andrea Luk ◽  
Ruchi Jain ◽  
Rashmi B. Prasad ◽  
Dmitry Shungin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Excess Risk ◽  
Proliferative Retinopathy

scholarly journals Ocular and Systemic Risk Markers for Development of Macular Edema and Proliferative Retinopathy in Type 2 Diabetes: A 5-Year Longitudinal Study

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. e12-e14
Author(s):  
António C.-V. Martinho ◽  
Inês P. Marques ◽  
Ana L. Messias ◽  
Torcato Santos ◽  
Maria H. Madeira ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Longitudinal Study ◽  
Macular Edema ◽  
Systemic Risk ◽  
Proliferative Retinopathy ◽  
Risk Markers

scholarly journals Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Valerio Costa ◽  
Amelia Casamassimi ◽  
Katherine Esposito ◽  
Angela Villani ◽  
Mariaelena Capone ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Direct Sequencing ◽  
Regulatory Region ◽  
Vascular Complications ◽  
Proliferative Retinopathy ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Significant Difference

Peroxisome proliferator-activated receptor gamma polymorphisms have been widely associated with type 2 diabetes, although their role in the pathogenesis of vascular complications is not yet demonstrated. In this study, a cohort of 211 type 2 diabetes, 205 obese, and 254 control individuals was genotyped for Pro12Ala, C1431T, C-2821T polymorphisms, and for a newly identified polymorphism (A-2819G). The above-mentioned polymorphisms were analyzed by gene-specific PCR and direct sequencing of all samples. A significant difference was found for -2819G frequency when patients with type 2 diabetes—particularly diabetic women with the proliferative retinopathy—were compared with healthy control individuals. In conclusion, we identified a novel polymorphism, A-2819G, inPPARGgene, and we found it to be associated with type 2 diabetes and proliferative retinopathy in diabetic females. In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not.

scholarly journals Relationship between Stage of Diabetic Retinopathy and Pulse Wave Velocity in Japanese Patients with Type 2 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Kumiko Tanaka ◽  
Toshihide Kawai ◽  
Yoshifumi Saisho ◽  
Shu Meguro ◽  
Kana Harada ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Japanese Patients ◽  
Proliferative Retinopathy ◽  
Cross Sectional ◽  
Significant Difference

Objectives. We investigated the relationship between the stage of diabetic retinopathy and pulse wave velocity (PWV).Methods. This was a cross-sectional study of 689 patients (406 men and 283 women) with type 2 diabetes who were admitted to our hospital from 2004 to 2007. Brachial-ankle pulse wave velocity (baPWV) was measured by an arterial pressure measurement device as PWV/ABI. Diagnosis of diabetic retinopathy was made by ophthalmologists based on the Davis classification: no diabetic retinopathy (NDR), simple retinopathy (SDR), pre-proliferative retinopathy (pre-PDR), and proliferative retinopathy (PDR).Results. There was a significant difference in PWV between patients without diabetic retinopathy (1657.0±417.9 m/s (mean ± SD)) and with diabetic retinopathy (1847.1±423.9 m/s) (P<0.001). In addition, the stage of diabetic retinopathy was associated with aortic PWV (1657.0±417.9 m/s in NDR (n=420),1819.4±430.3 m/s in SDR (n=152),1862.1±394.0 m/s in pre-PDR (n=54), and1901.1±433.5 m/s in PDR (n=63) (P<0.001)).Conclusions. In patients with diabetic retinopathy, even in those with SDR, PWV was higher than that in patients without diabetic retinopathy. Physicians should therefore pay attention to the value of PWV and macroangiopathy regardless of the stage of diabetic retinopathy.

Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients

2014 ◽  
Vol 40 (6) ◽  
pp. 452-458 ◽  
Author(s):  
C. Arndt ◽  
I. Leclercq ◽  
P. Nazeyrollas ◽  
A. Durlach ◽  
A. Ducasse ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Proliferative Retinopathy ◽  
Endothelial Lipase ◽  
Diabetes Patients

scholarly journals Prevalence of diabetic retinopathy in type 2 diabetes mellitus patients attending medicine out-patient department of a tertiary care hospital in Alappuzha, Kerala, India

2017 ◽  
Vol 5 (4) ◽  
pp. 1532 ◽  
Author(s):  
Koushiki Mani ◽  
Rose Davy C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Age At Onset ◽  
Proliferative Retinopathy ◽  
Duration Of Diabetes ◽  
Onset Of Diabetes ◽  
Patient Department

Background: Diabetic retinopathy is a microvascular complication affecting the eyes of both Type 1 and Type 2 diabetes mellitus due to long-term hyperglycaemia. Diabetic retinopathy is the leading cause of blindness among working aged adults around the world. There are various factors leading to the development of diabetic retinopathy namely duration of diabetes, glycaemic control, age at onset of diabetes, uncontrolled hypertension. This is a hospital based cross-sectional study which aimed to study the prevalence of diabetic retinopathy in type 2 diabetes mellitus patients attending Medicine out-patient department of Government T. D. Medical College, Alappuzha, Kerala, India. The factors contributing to the development of retinopathy was also studied.Methods: 200 already diagnosed type 2 diabetic subjects were included in the study. Subjects were explained about the study and once the consent was received, data regarding age, gender, age at onset of diabetes, duration of diabetes, history of smoking, alcohol intake, and socio-economic status was documented. Height and weight was measured. Blood pressure was recorded with mercury sphygmomanometer. Then the subjects were evaluated for diabetic retinopathy by fundus examination after dilating the eyes. Findings were noted and subjects were categorized as no retinopathy, nonproliferative and proliferative diabetic retinopathy using the ETDRS classification.Results: In present study, out of 200 subjects, 63 subjects (31.5%) were affected with diabetic retinopathy (non-proliferative retinopathy=22.5%, proliferative retinopathy=9%). Prevalence of mild, moderate and severe non-proliferative retinopathy was 7.5% each. Significant association was found between diabetic retinopathy and duration of diabetes.Conclusions: Therefore, periodic screening of diabetic patients should be carried out for early detection and prevention of loss of vision.

scholarly journals Glycaemic control and excess risk of major coronary events in patients with type 2 diabetes: a population-based study

Open Heart ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. e000967 ◽  
Author(s):  
Mauro Tancredi ◽  
Annika Rosengren ◽  
Ann-Marie Svensson ◽  
Aldina Pivodic ◽  
Soffia Gudbjörnsdottir ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
General Population ◽  
Cox Regression ◽  
Incidence Rates ◽  
Excess Risk ◽  
Control Group ◽  
Diabetes Group ◽  
Renal Complications

ObjectiveThe purpose of the study was to investigate the excess risk of acute myocardial infarction (AMI) and death from coronary artery disease (coronary heart disease, CHD) in relation to age, level of glycaemic control and renal complications in patients with type 2 diabetes.MethodsA total of 431 579 patients with type 2 diabetes mellitus registered in the Swedish National Diabetes Register from 1 January 1998 to 31 December 2012, and 2 173 620 controls from the general population were included. Cox regression was used to study the excess risk of AMI and CHD.ResultsDuring follow-up of 5.1 years in the diabetes group and 5.4 years in the control group, 36 124 (8.4%) and 115 712 (5.3%) CHD events were registered, with corresponding incidence rates/1000 person-years of 14.64 (95% CI 14.49 to 14.79) and 8.73 (95% CI 8.68 to 8.78), respectively. The HR after adjustment for sex and age was 1.67 (1.65–1.69) which was reduced to 1.42 (1.41–1.44) with further adjustment for level of education, country of birth, diabetes duration and comorbidities. The multivariable-adjusted HR for AMI and CHD death with a time-updated glycated haemoglobin level of 6.9% or lower (≤52 mmol/mol) together with normoalbuminuria and estimated glomerular filtration rate ≥60 mL/min for patients with diabetes compared with controls was 0.95 (95% CI 0.92 to 0.98, p<0.001).ConclusionsIn this study, the excess risk of AMI and CHD death was higher for patients with type 2 diabetes compared with controls but converged to that in the general population in patients with on-target HbA1c levels and without renal complications.

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