Retinal nerve fibre layer/ganglion cell‐inner plexiform layer thickness ratio in patients with systemic hypertension

2021 ◽  
Author(s):  
Woo Hyuk Lee ◽  
Min‐Woo Lee ◽  
Hyung‐Bin Lim ◽  
Min‐Su Kim ◽  
Cheon Kuk Ryu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Plexiform Layer ◽  
Retinal Nerve Fibre Layer ◽  
Thickness Ratio ◽  
Systemic Hypertension ◽  
Inner Plexiform Layer ◽  
Layer Thickness Ratio ◽  
Nerve Fibre Layer

Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes

2013 ◽  
Vol 97 (12) ◽  
pp. 1592-1597 ◽  
Author(s):  
Yih-Chung Tham ◽  
Carol Y Cheung ◽  
Victor T Koh ◽  
Ching-Yu Cheng ◽  
Elizabeth Sidhartha ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Nerve Fibre ◽  
Plexiform Layer ◽  
Retinal Nerve Fibre Layer ◽  
Inner Plexiform Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Thinning rates of retinal nerve layer and ganglion cell-inner plexiform layer in various stages of normal tension glaucoma

2019 ◽  
Vol 104 (8) ◽  
pp. 1131-1136
Author(s):  
Hiroko Inuzuka ◽  
Akira Sawada ◽  
Masayuki Inuzuka ◽  
Tetsuya Yamamoto
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Plexiform Layer ◽  
Normal Tension Glaucoma ◽  
Retinal Nerve Fibre Layer ◽  
Inner Plexiform Layer ◽  
Advanced Stage ◽  
Rates Of Change ◽  
Significant Difference ◽  
Nerve Fibre Layer

AimsTo compare the changes in the macular retinal nerve fibre layer (mRNFL), macular ganglion cell layer and inner plexiform layer (mGCIPL), and circumpapillary retinal nerve fibre layer (cpRNFL) in various stages of normal tension glaucoma (NTG) using spectral domain optical coherence tomography.MethodsEyes with NTG (n=218) were assigned into three groups based on initial mean deviation (MD) as follows: mild (MD>−6 dB), moderate (−6 dB≥MD≥−12 dB) and severe (−12 dB>MD>−20 dB). Annual rates of change in mRNFL, mGCIPL and cpRNFL thickness were calculated by linear regression analysis.ResultsAge, gender, spherical equivalent, and average intraocular pressure during follow-up were not significantly different among the three groups. There were significant differences in the mRNFL, mGCIPL and cpRNFL among the three groups at baseline (p<0.0001 in all sectors except for the mRNFL in the superonasal sector). The average thinning rates of the mRNFL, mGCIPL and cpRNFL were −0.38±0.32 µm/year, −0.62±0.46 µm/year and −0.86±0.83 µm/year, respectively. No significant difference in the rates of change in the mRNFL and mGCIPL were found among the groups in any sector. However, there was a significant difference in the rate of change in the cpRNFL among the groups (in all sectors: p<0.0001).ConclusionsChanges in the mRNFL and mGCIPL can reflect the progression of NTG even in its advanced stage. However, careful interpretation of changes in the cpRNFL in the advanced stage of glaucoma is warranted due to a potential floor effect.

scholarly journals Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects

2018 ◽  
Vol 103 (6) ◽  
pp. 821-825 ◽  
Author(s):  
Kunliang Qiu ◽  
Binyao Chen ◽  
Jianling Yang ◽  
Ce Zheng ◽  
Haoyu Chen ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Nerve Fibre ◽  
Healthy Subjects ◽  
Retinal Nerve Fibre Layer ◽  
Mean Deviation ◽  
Inner Plexiform Layer ◽  
Retinal Layers ◽  
Fibre Layer ◽  
Nerve Fibre Layer

PurposeTo determine the influence of the optic disc–fovea distance (DFD) on the normative classifications based on thickness measurements of macular inner retinal layers with spectral-domain optical coherence tomography (OCT) in healthy subjects.MethodsA total of 182 eyes from 182 healthy subjects were included (mean (SD) spherical equivalent −0.8 (1.9) dioptres). We performed macula and optic disc imaging with the Topcon 3D OCT 2000. The thickness of the macular inner retinal layers (macular retinal nerve fibre layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL) and both combined (ganglion cell complex; GCC)) and the corresponding classifications based on the built-in normative database were recorded. The occurrence of an abnormal normative classification (occurrence of any thickness variable below the fifth percentile) was related to the DFD and other factors (axial length/refraction, optic disc area, fovea–disc angle, age, gender, image quality, visual field mean deviation and peripapillary retinal nerve fibre layer thickness), using logistic regression.ResultsThe mean (SD) DFD was 4.90 (0.29) mm. A greater DFD was associated with a higher percentage of abnormal normative classification in the OCT parameters describing the thickness of the mRNFL (OR (95%CI) per 0.1 mm increase in DFD: 1.30 (1.13 to 1.50), p<0.001), GCIPL (1.18 (1.02 to 1.38), p=0.023) and GCC measurement (1.29 (1.08 to 1.55), p=0.006).ConclusionsEyes with a greater DFD are prone to false-positive classifications in the thickness assessment of the macular inner retinal layers. The thicknesses should always be interpreted in the context of DFD.

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