scholarly journals Statin use and the reoperation rates in glaucoma filtration surgery – population‐based cohort study

2021 ◽  
Author(s):  
Aapo Virtanen ◽  
Jari Haukka ◽  
Mika Harju ◽  
Sirpa Loukovaara
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Reoperation Rates ◽  
Statin Use

scholarly journals Statin use and its effect on all‐cause mortality of melanoma patients: a population‐based Dutch cohort study

2014 ◽  
Vol 3 (5) ◽  
pp. 1284-1293 ◽  
Author(s):  
Elisabeth Livingstone ◽  
Loes M. Hollestein ◽  
Myrthe P. P. Herk‐Sukel ◽  
Lonneke Poll‐Franse ◽  
Arjen Joosse ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
All Cause Mortality ◽  
Melanoma Patients ◽  
Dutch Cohort ◽  
Statin Use

scholarly journals Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study

2017 ◽  
Vol 116 (12) ◽  
pp. 1652-1659 ◽  
Author(s):  
Ronan T Gray ◽  
Maurice B Loughrey ◽  
Peter Bankhead ◽  
Chris R Cardwell ◽  
Stephen McQuaid ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Mevalonate Pathway ◽  
Population Based ◽  
Statin Use

scholarly journals Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study

2016 ◽  
Vol 150 (4) ◽  
pp. 854-865.e1 ◽  
Author(s):  
Leo Alexandre ◽  
Allan B. Clark ◽  
Hina Y. Bhutta ◽  
Simon S.M. Chan ◽  
Michael P.N. Lewis ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cohort Study ◽  
Population Based ◽  
Statin Use

scholarly journals Statin use and mortality in rheumatoid arthritis: a general population-based cohort study

2015 ◽  
Vol 75 (7) ◽  
pp. 1315-1320 ◽  
Author(s):  
Sara R Schoenfeld ◽  
Leo Lu ◽  
Sharan K Rai ◽  
John D Seeger ◽  
Yuqing Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
General Population ◽  
Population Based ◽  
Statin Use

Abstract 17830: Statin Use is Associated With a Reduced Risk of Intracerebral Hemorrhage Recurrence: A Population-based Cohort Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mei-Chuan Chou ◽  
Kai-Hung Cheng ◽  
Chih-Sheng Chu ◽  
Yu-Han Chang ◽  
Liang-Yin Ke ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Intracerebral Hemorrhage ◽  
Fold Increase ◽  
Population Based ◽  
Research Database ◽  
Dependent Manner ◽  
Defined Daily Doses ◽  
Reduced Risk ◽  
Statin Use

Background: The safety of statin use in patients with intracerebral hemorrhage (ICH) is an unsettled issue of critical importance during stroke management. To assess the benefits and risks of statin use in ICH patients, we analyzed the big data from the Taiwan National Health Insurance Research Database (NHIRD) collected from a population known to have a higher ICH incidence than the Westerners. Methods and Results: A random sample of 1,000,000 subjects representative of the 23-million population registered in the NHIRD from 1997 to 2010 was used for this retrospective cohort study. The cumulative risks of ICH, ischemic stroke, and transient ischemic attack (TIA) were analyzed among three ICH cohorts: non-statin (NS; no statin use before or after ICH), statin (S; continued or initiated statin use after ICH), and statin-withdrawal (SW; statin use discontinued after ICH). A total of 2408 ICH patients (age 63.4±14.2 years, 62.5% male) were identified between 2000 and 2005 and followed for an average of 7.0 years. A Cox proportional hazard regression model was applied to estimate the hazard ratios (HRs) with adjustment for potential confounders. Compared to NS, S had a 71% (HR 0.29, CI 0.19-0.43; P<0.001) reduction in ICH recurrence (Figure). The risk of ICH recurrence decreased as a function of the increment of cumulative defined daily doses (P trend <0.0001). In contrast, SW had a 1.5-fold increase in ICH recurrence (HR 1.55, CI 1.09-2.22; P=0.016) and a 2-fold increase in ischemic stroke or TIA development (HR 2.01,CI 1.30-3.11; P=0.002). Conclusions: Based on this large database, continuation or initiation of stain use in ICH patients is associated with a reduced risk of ICH recurrence in a dose-dependent manner; discontinuation of statin use confers significant risks for both ICH recurrence and ischemic stroke/TIA development. Mechanistic studies are warranted to further validate the significance of this observation.

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