scholarly journals Investigating the neuroprotective effect of Copolymer‐1 in acute primary angle closure – Interim report of a randomized placebo‐controlled double‐masked clinical trial

2019 ◽  
Vol 97 (6) ◽  
Author(s):  
Kenric Rui‐Pin Fan ◽  
Mani Baskaran ◽  
Monisha E. Nongpiur ◽  
Hla Mynt Htoon ◽  
John Mark S. de Leon ◽  
...  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kangcheng Liu ◽  
Huizhuo Xu ◽  
Haibo Jiang ◽  
Hua Wang ◽  
Pingbao Wang ◽  
...  

Abstract This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.


2015 ◽  
Vol 27 (3-4) ◽  
pp. 70-75 ◽  
Author(s):  
Sasan Moghimi ◽  
Hesam Hashemian ◽  
Rebecca Chen ◽  
Mohammadkarim Johari ◽  
Massood Mohammadi ◽  
...  

2016 ◽  
Vol 166 ◽  
pp. 133-140 ◽  
Author(s):  
Sasan Moghimi ◽  
Rebecca Chen ◽  
Mohammadkarim Johari ◽  
Faezeh Bijani ◽  
Massood Mohammadi ◽  
...  

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