scholarly journals Combined cellular and soluble mediator analysis for improved diagnosis of vitreoretinal lymphoma

2019 ◽  
Vol 97 (6) ◽  
pp. 626-632 ◽  
Author(s):  
Joeri Hoog ◽  
Willem A. Dik ◽  
Lucy Lu ◽  
Kim C. Heezen ◽  
Josianne C. ten Berge ◽  
...  
Keyword(s):  
Mediator Analysis ◽  
Soluble Mediator ◽  
Vitreoretinal Lymphoma

Retinal and Choroidal Changes of Vitreoretinal Lymphoma from Active to Remission Phase after Intravitreal Rituximab

2019 ◽  
Vol 28 (4) ◽  
pp. 637-646 ◽  
Author(s):  
Maria Vittoria Cicinelli ◽  
Alessandro Marchese ◽  
Elisabetta Miserocchi ◽  
Chiara Giuffré ◽  
Luigi Berchicci ◽  
...  
Keyword(s):  
Vitreoretinal Lymphoma ◽  
Remission Phase

Recurrence of Primary Breast Lymphoma Presenting as Bilateral Vitreoretinal Lymphoma

2021 ◽  
pp. 1-5
Author(s):  
Karishma Habbu ◽  
Roshan George ◽  
Miguel Materin
Keyword(s):  
Brain Mri ◽  
B Cell Lymphoma ◽  
Intrathecal Chemotherapy ◽  
Primary Breast Lymphoma ◽  
Blurred Vision ◽  
Breast Lymphoma ◽  
Central Nervous System Penetration ◽  
Vitreoretinal Lymphoma ◽  
The Right ◽  
Vitreous Biopsy

<b><i>Purpose:</i></b> This report describes a case of relapsed primary breast lymphoma (PBL) presenting as vitreoretinal lymphoma (VRL). <b><i>Methods:</i></b> We describe the clinical and hematopathologic findings in a patient with relapsed PBL involving the vitreous of both eyes. <b><i>Results:</i></b> A 59-year-old woman was treated for PBL with systemic and intrathecal chemotherapy 5 years prior to presentation. Three years later, she presented to an outside clinic with blurred vision in both eyes and bilateral vitritis. She was referred to our clinic with concern for ocular lymphoma. On presentation, the patient’s best-corrected visual acuity was 20/40 in the right eye and 20/25 in the left eye with 3+ vitreous cells in the right eye and 2+ vitreous cells in the left eye. Vitreous biopsy of the right eye revealed CD5-negative/CD10-negative B-cell lymphoma cells on flow cytometry. She had no evidence of disease on brain MRI, lumbar puncture, bone marrow biopsy, or full-body CT scans. She was treated with a regimen of rituximab, methotrexate, procarbazine, and vincristine for central nervous system penetration as well as multiple intraocular injections of methotrexate and rituximab with improvement in vision and ocular inflammation bilaterally. <b><i>Conclusion:</i></b> Relapsed PBL can present as bilateral VRL.

scholarly journals Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages.

1980 ◽  
Vol 152 (6) ◽  
pp. 1684-1698 ◽  
Author(s):  
M G Scher ◽  
D I Beller ◽  
E R Unanue
Keyword(s):  
T Cells ◽  
Listeria Monocytogenes ◽  
T Lymphocytes ◽  
Fc Receptors ◽  
Antigen Challenge ◽  
Immune Mediator ◽  
Soluble Mediator ◽  
C3 Receptors

Previous studies have shown that Listeria monocytogenes-immune T cells, adoptively transferred into normal mice with killed Listeria organisms, induced peritoneal exudates rich in Ia-positive macrophages. We show now that culture fluids generated by Listeria-immune exudate cells and Listeria contain an activity that elicits Ia-rich exudates when injected intraperitoneally. The factor that recruits Ia-positive macrophages must be injected several times during a 2-d period for optimal demonstration of its activity. The induction of the factor is immunologically specific and requires Ia-positive macrophages, primed T lymphocytes, and antigen challenge. The factor is a nondialyzable protein and is not genetically restricted in its activity. The macrophages in the exudates induced by the factor bear Fc receptors, take up latex, synthesize I-A, but bear few C3 receptors. We have thus identified an immune mediator capable of controlling the Ia phenotype of the exudate macrophages.

scholarly journals Primary vitreoretinal lymphoma

2019 ◽  
Vol 33 (1) ◽  
pp. 66-80 ◽  
Author(s):  
Dimitrios Kalogeropoulos ◽  
Georgios Vartholomatos ◽  
Arijit Mitra ◽  
Ibrahim Elaraoud ◽  
Soon Wai Ch'ng ◽  
...  
Keyword(s):  
Primary Vitreoretinal Lymphoma ◽  
Vitreoretinal Lymphoma
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