scholarly journals Hypoxia challenge test and retinal circulation changes - a study using ocular coherence tomography angiography

2017 ◽  
Vol 96 (3) ◽  
pp. e315-e319 ◽  
Author(s):  
David Cordeiro Sousa ◽  
Inês Leal ◽  
Susana Moreira ◽  
Patrícia Dionísio ◽  
Luís Abegão Pinto ◽  
...  
Keyword(s):  
Challenge Test ◽  
Retinal Circulation ◽  
Ocular Coherence Tomography ◽  
Circulation Changes ◽  
Ocular Coherence Tomography Angiography

Multimodal imaging of pigmented paravenous retinochoroidal atrophy

2020 ◽  
pp. 112067212096548
Author(s):  
Ratnesh Ranjan ◽  
Arvind Jain M ◽  
Shishir Verghese ◽  
George J Manayath ◽  
Venkatapathy Narendran
Keyword(s):  
Multimodal Imaging ◽  
Early Stage ◽  
Anterior Segment ◽  
Fundus Examination ◽  
Swept Source ◽  
Ocular Coherence Tomography ◽  
Corrected Visual Acuity ◽  
Pigmented Paravenous Retinochoroidal Atrophy ◽  
Best Corrected Visual Acuity ◽  
Ocular Coherence Tomography Angiography

Aim: To describe the multimodal imaging findings of pigmented paravenous retinochoroidal atrophy. Methods: A 23-year-old female presented to us for a routine ocular examination. She had a best-corrected visual acuity of 6/6 in both eyes. Anterior segment examination was unremarkable. Fundus examination showed pigmentary changes along the retinal vasculature extending from mid periphery to post-equatorial retina suggesting a diagnosis of pigmented paravenous retinochoroidal atrophy. Swept-source optical coherence tomography of the macula showed choriocapillaris thinning at the mid periphery whereas coherence tomography angiography at the mid periphery showed a relatively normal choriocapillaris vasculature in the early stage of the disease. Conclusion: A relatively normal choriocapillaris structure was seen on ocular coherence tomography angiography which could have been due to a milder form of the disease in a young patient.

scholarly journals Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium

2019 ◽  
Vol 67 (4) ◽  
pp. 563 ◽  
Author(s):  
PMahesh Shanmugam ◽  
VinayaKumar Konana ◽  
Rajesh Ramanjulu ◽  
KC Divyansh Mishra ◽  
Pradeep Sagar ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Ocular Coherence Tomography ◽  
Congenital Hypertrophy ◽  
Ocular Coherence Tomography Angiography

Vibrio harveyi virulence gene expression in vitro and in vivo during infection in black tiger shrimp Penaeus monodon

2020 ◽  
Vol 139 ◽  
pp. 153-160
Author(s):  
S Peeralil ◽  
TC Joseph ◽  
V Murugadas ◽  
PG Akhilnath ◽  
VN Sreejith ◽  
...  
Keyword(s):  
Gene Expression ◽  
Virulence Genes ◽  
Vibrio Harveyi ◽  
Penaeus Monodon ◽  
Challenge Test ◽  
Virulence Gene ◽  
Economic Losses ◽  
Virulence Gene Expression

Luminescent Vibrio harveyi is common in sea and estuarine waters. It produces several virulence factors and negatively affects larval penaeid shrimp in hatcheries, resulting in severe economic losses to shrimp aquaculture. Although V. harveyi is an important pathogen of shrimp, its pathogenicity mechanisms have yet to be completely elucidated. In the present study, isolates of V. harveyi were isolated and characterized from diseased Penaeus monodon postlarvae from hatcheries in Kerala, India, from September to December 2016. All 23 tested isolates were positive for lipase, phospholipase, caseinase, gelatinase and chitinase activity, and 3 of the isolates (MFB32, MFB71 and MFB68) showed potential for significant biofilm formation. Based on the presence of virulence genes, the isolates of V. harveyi were grouped into 6 genotypes, predominated by vhpA+ flaB+ ser+ vhh1- luxR+ vopD- vcrD+ vscN-. One isolate from each genotype was randomly selected for in vivo virulence experiments, and the LD50 ranged from 1.7 ± 0.5 × 103 to 4.1 ± 0.1 × 105 CFU ml-1. The expression of genes during the infection in postlarvae was high in 2 of the isolates (MFB12 and MFB32), consistent with the result of the challenge test. However, in MFB19, even though all genes tested were present, their expression level was very low and likely contributed to its lack of virulence. Because of the significant variation in gene expression, the presence of virulence genes alone cannot be used as a marker for pathogenicity of V. harveyi.

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