Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

2016 ◽  
Vol 95 (1) ◽  
pp. e36-e42 ◽  
Author(s):  
Gilda Cennamo ◽  
Mario R. Romano ◽  
Giuseppe Nicoletti ◽  
Nunzio Velotti ◽  
Giuseppe de Crecchio
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Diabetic Maculopathy

scholarly journals Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ketaki Rajurkar ◽  
Meenakshi Thakar ◽  
Priyadarshi Gupta ◽  
Anju Rastogi
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Disease Process ◽  
Cystoid Macular Oedema ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Indirect Ophthalmoscopy ◽  
Eales Disease

Abstract Purpose To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Any media opacity precluding the above investigations was excluded. Results Macular findings comprised of- epiretinal membrane, macular exudation, full thickness macular hole, sub internal limiting membrane bleed, cystoid macular oedema, neurosensory detachment and retinal thickening. Sixteen (51.6%) of our patients had macular changes as seen on all modalities together. SLB and indirect ophthalmoscopy missed macular findings in 50% patients and FA in 18.8% patients. OCT and OCTA diagnosed all macular findings. On comparison of mean BCVA in patients with macular involvement on FA, OCT and OCTA, compared to those without macular involvement, patients with macular involvement had lower BCVA (p 0.000, 0.01 and 0.001 respectively). Thus, FA missed many patients who had significant macular involvement and hence less vision. Conclusion Eales disease though described in literature as classically being peripheral retina disease process, also has macular involvement. OCT and OCTA are useful guides to evaluation of macular involvement in these patients. The latter seems to be superior to FA in detecting macular abnormalities in this ailment. OCTA is non-invasive and shows deep capillary plexus changes which are not shown by any other modality.

Fundus Fluorescein Angiography, Optical Coherence Tomography, and Optical Coherence Tomography Angiography Findings in Branch Retinal Vein Occlusion

2019 ◽  
pp. 83-87
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Serous Retinal Detachment ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Vein Occlusion ◽  
Capillary Plexus

Even though the diagnosis depends on clinical examination, in cases with branch retinal vein occlusion (BRVO), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) provide unique data for follow-up, management and prognosis. In FFA, delay of laminar flow phase in the involved branch, hyperfluorescence due to leakage from the vessel wall in the late phases, hypofluorescence due to the blockage by hemorrhage, and soft exudates, and hyperfluorescence due to macular edema can be detected. In OCT, macular thickening, cystic spaces, serous retinal detachment, hyperreflective dots, disorganization of the outer retinal layers – particularly the photoreceptor inner and outer segments line and the external limiting membrane – can be seen. OCTA reveals non-perfusion, particularly in the deep capillary plexus.

Detection, localization, and characterization of vision-threatening features of microaneurysms using optical coherence tomography angiography in diabetic maculopathy

2020 ◽  
pp. 112067212092460 ◽  
Author(s):  
Anadi Khatri ◽  
Eli Pradhan ◽  
Bal Kumar KC ◽  
Muna Kharel ◽  
Roshija Khanal Rijal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Optical Coherence Tomography Angiography ◽  
High Flow ◽  
Imaging Modalities ◽  
Low Flow ◽  
Optical Coherence ◽  
Diabetic Maculopathy ◽  
Capillary Plexus

Introduction Diabetic maculopathy is a leading retinal cause of blindness. This study was conducted using optical coherence tomography angiography and noninvasive imaging modalities. Microaneurysms were evaluated for location, flow, and adjacent retinal tissue changes to establish knowledge of possible vision-threatening features. Methodology: This is a hospital-based, cross-sectional observational study. Eighteen patients with diabetic maculopathy were included in the study. Fundus photo, red-free filter image, infrared images with shadowgrams, optical coherence tomography cross sections, and optical coherence tomography angiography were analyzed. Mean, standard deviation, odds ratio, and 95% confidence interval were used for statistical analysis, and p-value of <0.05 was considered statistically significant where applicable. Results A total of 64 microaneurysms were evaluated. Forty-six (71.8%) microaneurysms were identifiable in all imaging modalities. In total, 53 (82.8%) were high-flow microaneurysms and 11 (17.2%) were low-flow microaneurysms. Thirty-eight of the high-flow microaneurysms (71.6% of the high-flow microaneurysms) were found in the deep capillary plexus, while only 15 (28.4% of the high-flow microaneurysms) were found in the superficial capillary plexus. Twenty-seven (71%) of the high-flow microaneurysms in deep capillary plexus were present in the areas of retinal thickening (odds ratio: 4.5, 95% confidence interval: 1.26–16.0, p = 0.02). A total of 11 microaneurysms were classified as low-flow microaneurysms and identified using fundus photo, red-free filter image, infrared images with shadowgrams, and optical coherence tomography—cross sections. They had a tendency to be present in the areas of decreased capillary plexus density (odds ratio: 25.6, 95% confidence interval: 5.09–128.7, p = 0.001). Conclusion Noninvasive imaging modalities combined with optical coherence tomography angiography can provide valuable information regarding microaneurysms. Certain features such as location and flow may help in predicting impending macular edema or ischemia.

Fluorescein angiography versus optical coherence tomography angiography: FA vs OCTA Italian Study

2020 ◽  
pp. 112067212090976
Author(s):  
Maria Cristina Savastano ◽  
Marco Rispoli ◽  
Bruno Lumbroso ◽  
Luca Di Antonio ◽  
Leonardo Mastropasqua ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Clinical Practice ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Real Life ◽  
Optical Coherence ◽  
Everyday Clinical Practice ◽  
Italian Study ◽  
Observation Period

Purpose: To assess the current role of fluorescein angiography after the introduction of optical coherence tomography angiography in real-life clinical practice. Methods: This was a multicentric retrospective observational study to evaluate the number of fluorescein angiography and optical coherence tomography angiography procedures performed by different devices from January 2013 to December 2018. The centers involved were Centro Italiano Macula (Rome), and ophthalmology departments of University “G. D’Annunzio” Chieti–Pescara (Chieti) and “Azienda Ospedaliero Universitaria Careggi” (Florence). Results: Out of 19,898 total fluorescein angiography procedures performed in the observation period, 3444 (17.3%) were in 2013, 3972 (19.9%) were in 2014, 3601 (18.1%) were in 2015, 3407 (17.2%) were in 2016, 3285 (16.5%) were in 2017, and 2189 (11%) were in 2018. Out of 7949 optical coherence tomography angiography procedures performed in the observation period, none were performed in 2013, 550 (6.9%) were in 2014, 908 (11.5%) were in 2015, 2098 (26.4%) were in 2016, 2090 (26.3%) were in 2017, and 2303 (28.9%) were in 2018. Conclusion: Fluorescein angiography procedures were performed less often after the introduction of optical coherence tomography angiography technology. The ease, speed, and safety of the optical coherence tomography angiography procedure in everyday clinical practice have facilitated more optical coherence tomography angiography application compared to fluorescein angiography in recent years. In the future, we will probably evaluate the different pathologies that still need an evaluation by fluorescein angiography.

scholarly journals Exudative Type 3 Retinal Arteriovenous Malformation in a Pediatric Patient

2018 ◽  
Vol 9 (3) ◽  
pp. 504-509
Author(s):  
Helena Dens ◽  
Ingele Casteels
Keyword(s):  
Optical Coherence Tomography ◽  
Differential Diagnosis ◽  
Arteriovenous Malformation ◽  
Fluorescein Angiography ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Imaging Techniques ◽  
Optical Coherence ◽  
The Right ◽  
Type 3

We describe a 7-year-old girl who developed exudation nasally to the right optic disc due to retinal arteriovenous malformation. Fluorescein angiography, spectral domain optical coherence tomography, and optical coherence tomography angiography were performed. We give an overview of the different imaging techniques and discuss the differential diagnosis. Since there was no visual impairment, no treatment was started. A spontaneous decrease in edema and exudation was noted after 6 months.

scholarly journals Optical Coherence Tomography Angiography of Retinal Arterial Macroaneurysm before and after Treatment

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Victoria S. Chang ◽  
Stephen G. Schwartz ◽  
Harry W. Flynn
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Intravitreal Bevacizumab ◽  
Optical Coherence ◽  
Flow Signal ◽  
Retinal Arterial Macroaneurysm ◽  
Diagnosis And Management ◽  
Before And After

A case of retinal arterial macroaneurysm (RAM) is presented with multimodal imaging, including commercially available optical coherence tomography angiography (OCT-A). Following treatment with intravitreal bevacizumab, reduction of flow signal through the RAM is documented. OCT-A provides useful information for the diagnosis and management of at least some patients with RAM, without the need for traditional fluorescein angiography.

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