scholarly journals The prognostic value of retinal vessel analysis in primary open-angle glaucoma

2016 ◽  
Vol 94 (6) ◽  
pp. e474-e480 ◽  
Author(s):  
Nicolas Philipp Waldmann ◽  
Asan Kochkorov ◽  
Anna Polunina ◽  
Selim Orgül ◽  
Konstantin Gugleta
Keyword(s):  
Prognostic Value ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Open Angle ◽  
Retinal Vessel Analysis

scholarly journals Association between Systemic Antioxidant Capacity and Retinal Vessel Diameters in Patients with Primary-Open Angle Glaucoma

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 364
Author(s):  
Yuji Takayanagi ◽  
Yasuyuki Takai ◽  
Sachiko Kaidzu ◽  
Masaki Tanito
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Vessel Diameter ◽  
Reactive Oxygen Metabolites ◽  
Open Angle ◽  
Pressure Independent ◽  
Retinal Vessel Diameters

The retinal vessel narrowing may be implicated in the pathogenesis of glaucoma; however, the association between systemic oxidative stress and retinal vessel diameter remains largely unknown. We examined the relationship between serum oxidative stress markers and retinal vessel diameters in eyes with primary open-angle glaucoma (POAG) and cataract, using central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE). We included 66 eyes of 66 patients with POAG (37 men, 29 women; 65.4 ± 11.7 years) and 20 eyes of 20 patients with cataract (7 men, 13 women; 69.4 ± 9.0 years) as the controls. The CRAE (p < 0.0001), CRVE (p < 0.0001), and serum biological antioxidant potential (BAP) (p = 0.0419) were significantly lower in the POAG group compared to the controls. The BAP showed significant correlation both with CRAE (ρ = 0.2148, p = 0.0471) and systolic blood pressure (ρ = −0.2431, p = 0.0241), while neither Diacron reactive oxygen metabolites nor sulfhydryl test correlated with them. The multivariate analyses indicated that age, best corrected visual acuity, and BAP were independent factors for CRAE or CRVE. The present study suggested that lower systemic antioxidant capacity was significantly associated with the intraocular pressure-independent vascular narrowing in POAG patients. This study provided a novel insight into the pathophysiology of glaucoma and highlighted the clinical impact on systemic antioxidant treatment for patients with glaucoma.

scholarly journals Retinal vessel phenotype in patients with primary open‐angle glaucoma

2019 ◽  
Vol 98 (1) ◽  
Author(s):  
Christophe Chiquet ◽  
Olivier Gavard ◽  
Louis Arnould ◽  
Thibaud Mautuit ◽  
Tom J. Macgillivray ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Open Angle

scholarly journals OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hannah Weindler ◽  
Martin S. Spitzer ◽  
Maximilian Schultheiß ◽  
Robert Kromer
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Retinal Blood Flow ◽  
Flow Density ◽  
Open Angle ◽  
Post Surgery ◽  
Retinal Vessel Density

Abstract Background Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals. Methods The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost (n = 20) compared to surgically treated patients with normal IOP (n = 22) using optical coherence tomography angiography (OCT-A). The retinal flow density was obtained after binarisation and evaluated in five sectors. Results There was a significantly higher peripapillary flow density in all sectors in Tafluprost treated eyes when compared to post-surgery eyes. The flow density in the inferior sector of the superficial plexus in the macular region was also significantly higher in the Tafluprost group. Conclusions: These results indicate that Tafluprost not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.

Rigidity of Retinal Vessel in Untreated Eyes of Normal Tension Primary Open-angle Glaucoma Patients

2011 ◽  
Vol 20 (5) ◽  
pp. 303-306 ◽  
Author(s):  
Alexander Oettli ◽  
Konstantin Gugleta ◽  
Asan Kochkorov ◽  
Robert Katamay ◽  
Josef Flammer ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Open Angle

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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