Lamina cribrosa defects in eyes with glaucomatous disc haemorrhage

2015 ◽  
Vol 94 (6) ◽  
pp. e468-e473 ◽  
Author(s):  
Young Kook Kim ◽  
Ki Ho Park
Keyword(s):  
Lamina Cribrosa ◽  
Disc Haemorrhage

Association between focal lamina cribrosa defects and optic disc haemorrhage in glaucoma

2019 ◽  
Vol 104 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Vijay Mistry ◽  
Dong An ◽  
Christopher J Barry ◽  
Philip H House ◽  
William H Morgan
Keyword(s):  
Optic Disc ◽  
Rank Correlation ◽  
Lamina Cribrosa ◽  
Enhanced Depth Imaging ◽  
Spearman Rank Correlation ◽  
Depth Imaging ◽  
Disc Haemorrhage ◽  
B Scan Images ◽  
The Relationship

Background/aimsTo explore the relationship between focal lamina defect (LD) size and optic disc haemorrhages (DH) in glaucomatous eyes.MethodsRadial B-scan images at 15° intervals obtained using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT) were performed on a group of subjects previously assessed for DH every 3 months over a period of 5 years. EDI-OCT scans were assessed for the presence of focal lamina cribrosa defects by a single observer.Results119 eyes from 62 subjects (44 females, 18 males) were analysed. 44 eyes (37%) were noted to have at least 1 LD, and of those, eight eyes had more than one defect. 68 eyes (57%) were observed to have at least one DH occur over the course of monitoring. 48 eyes (40%) had recurrent DH, with a mean of 5.17 haemorrhages over the 5-year period. Type 1 focal LD (p=0.0000, OR 7.17), glaucoma progression (p=0.0024, OR 0.32) and ArtDiff (p=0.0466, OR 1.04) were significantly associated as predictors of DH. No correlation between the size of the LD and DH occurrence (p=0.6449, Spearman rank correlation) was found.ConclusionFocal lamina cribrosa hole-type defects were significantly associated with an increase in DH occurrence over the preceding 5 years. The lack of association between defect size and DH suggests that DH and lamina defects may have separate links to the glaucomatous process.

scholarly journals Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Elizabeth M McElnea ◽  
Emily Hughes ◽  
Aloysius McGoldrick ◽  
Amanda McCann ◽  
Barry Quill ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Lipofuscin Accumulation

scholarly journals Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

2011 ◽  
Vol 52 (10) ◽  
pp. 7109 ◽  
Author(s):  
Hongli Yang ◽  
Galen Williams ◽  
J. Crawford Downs ◽  
Ian A. Sigal ◽  
Michael D. Roberts ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Experimental Glaucoma ◽  
Outward Migration

scholarly journals Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Ophthalmology ◽  
2017 ◽  
Vol 124 (11) ◽  
pp. 1600-1611 ◽  
Author(s):  
Yu Sawada ◽  
Makoto Araie ◽  
Makoto Ishikawa ◽  
Takeshi Yoshitomi
Keyword(s):  
Visual Field ◽  
Lamina Cribrosa ◽  
Visual Field Defects ◽  
Field Defects

Association of systemic cardio-vasculature status with retinal vascular endothelium in diabetes

2020 ◽  
Vol 1 (1) ◽  
pp. 52-57
Author(s):  
Galina Dimitrova ◽  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Arterial Stiffness ◽  
Vascular Endothelium ◽  
Lamina Cribrosa ◽  
Central Retinal Artery ◽  
Diabetic Patients ◽  
Retinal Artery ◽  
Central Retinal Vein

The relationship between diabetic retinopathy and macro-vascular complications in diabetes suggests a pathogenic association between these conditions. Vascular endothelium has been identified as a main site of blood vessel injury in diabetes. Diabetic retinopathy is associated with systemic arterial stiffness and altered vascular endothelium function and structure. Retinal vasculature endothelium at the macula, arterio-venous crossings, and in the optic nerve at the lamina cribrosa region is reported to differ from the endothelium in the rest of the retinal blood vessels. The central retinal artery and vein are in close proximity in the optic nerve where they share a common adventitia; thus, increased arterial wall stiffness and thickness may affect blood flow in the neighboring central retinal vein in this region. Moreover, increased arterial stiffness in small arterial beds is associated with retinal venular widening; it suggests the possibility of central retinal artery compressing the central retinal vein at the lamina cribrosa, thereby compromising venular outflow in the retina of diabetic patients. Altered blood flow in the central retinal vein in the postlaminar region has been detected in patients who experience progression of diabetic retinopathy. Increased hydrostatic pressure in the central retinal vein may play a major role in the pathogenesis of diabetic retinopathy. The aim of this review article is to emphasize this pathogenetic mechanism that has often been overlooked.

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