scholarly journals Early risk stratification in paediatric type 1 diabetes

2015 ◽  
Vol 93 ◽  
pp. 1-19 ◽  
Author(s):  
Rebecca Broe
Keyword(s):  
Type 1 Diabetes ◽  
Risk Stratification ◽  
Early Risk

scholarly journals Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254859
Author(s):  
Elisabeth Buur Stougaard ◽  
Signe Abitz Winther ◽  
Hanan Amadid ◽  
Marie Frimodt-Møller ◽  
Frederik Persson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Risk Stratification ◽  
Boundary Region ◽  
Cross Sectional Study ◽  
Endothelial Glycocalyx ◽  
Capillary Endothelium ◽  
Microvascular Damage ◽  
Cross Sectional

Background Glycocalyx lines the inner surface of the capillary endothelium. Capillaroscopy enables visualization of the sublingual capillaries and measurement of the Perfused Boundary Region (PBR) as an estimate of the glycocalyx. Novel software enables assessment of the PBR estimated at a fixed high flow level (PBR-hf) and an overall microvascular assessment by the MicroVascular Health Score (MVHS). Damaged glycocalyx may represent microvascular damage in diabetes and assessment of its dimension might improve early cardio-renal risk stratification. Aim To assess the associations between PBR, PBR-hf and MVHS and cardio-renal risk factors in persons with type 1 diabetes (T1D); and to compare these dimensions in persons with T1D and controls. Methods Cross-sectional study including 161 persons with T1D stratified according to level of albuminuria and 50 healthy controls. The PBR, PBR-hf and MVHS were assessed by the GlycoCheck device (valid measurements were available in 136 (84.5%) with T1D and in all the controls). Higher PBR and PBR-hf indicate smaller glycocalyx width. Lower MVHS represents a worse microvascular health. Results There were no associations between PBR, PBR-hf or MVHS and the cardio-renal risk factors in persons with T1D, except for higher PBR-hf and lower MVHS in females (p = 0.01 for both). There was no difference in PBR, PBR-hf or MVHS in persons with normo-, micro- or macroalbuminuria. The PBR was higher (2.20±0.30 vs. 2.03±0.18μm; p<0.001) and MVHS lower (3.15±1.25 vs. 3.53±0.86μm; p = 0.02) in persons with T1D compared to controls (p≤0.02). After adjustment for cardio-renal risk factors the difference in PBR remained significant (p = 0.001). Conclusions The endothelial glycocalyx dimension was impaired in persons with T1D compared to controls. We found no association between the endothelial glycocalyx dimension and the level of albuminuria or cardio-renal risk factors among persons with T1D. The use of the GlycoCheck device in T1D may not contribute to cardio-renal risk stratification.

Early Risk Factors for Nonadherence in Pediatric Type 1 Diabetes: A Review of the Recent Literature

2010 ◽  
Vol 6 (3) ◽  
pp. 167-183 ◽  
Author(s):  
David D. Schwartz ◽  
Virginia D. Cline ◽  
Jennifer A. Hansen ◽  
Marni E. Axelrad ◽  
Barbara J. Anderson
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Recent Literature ◽  
Early Risk ◽  
Early Risk Factors ◽  
Pediatric Type 1 Diabetes
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