Retinal outer layer thickness increases with regression of multiple evanescent white dot syndrome and visual improvement positively correlates with photoreceptor outer segment length

2014 ◽  
Vol 92 (7) ◽  
pp. e591-e592 ◽  
Author(s):  
Yuki Hashimoto ◽  
Wataru Saito ◽  
Michiyuki Saito ◽  
Kiriko Hirooka ◽  
Chikako Yoshizawa ◽  
...  
Keyword(s):  
Layer Thickness ◽  
Outer Layer ◽  
Outer Segment ◽  
Segment Length ◽  
Photoreceptor Outer Segment ◽  
White Dot Syndrome ◽  
Visual Improvement

scholarly journals Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (5) ◽  
pp. 1347 ◽  
Author(s):  
Norihiro Nagai ◽  
Sakiko Minami ◽  
Misa Suzuki ◽  
Hajime Shinoda ◽  
Toshihide Kurihara ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Outer Segment ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Segment Length ◽  
Macular Pigment Optical Density ◽  
Photoreceptor Outer Segment ◽  
Age Related ◽  
Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

scholarly journals Comparison of photoreceptor outer segment length in diabetic and idiopathic epiretinal membranes

Eye ◽  
2015 ◽  
Vol 29 (11) ◽  
pp. 1446-1452 ◽  
Author(s):  
K Yüksel ◽  
Y Karaküçük ◽  
A Özkaya ◽  
G Pekel ◽  
Ö Baz ◽  
...  
Keyword(s):  
Outer Segment ◽  
Segment Length ◽  
Photoreceptor Outer Segment ◽  
Epiretinal Membranes

scholarly journals RELATIONSHIP BETWEEN PHOTORECEPTOR OUTER SEGMENT LENGTH AND VISUAL ACUITY IN DIABETIC MACULAR EDEMA

Retina ◽  
2010 ◽  
Vol 30 (1) ◽  
pp. 63-70 ◽  
Author(s):  
FARZIN FOROOGHIAN ◽  
PAUL F. STETSON ◽  
SCOTT A. MEYER ◽  
EMILY Y. CHEW ◽  
WAI T. WONG ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Outer Segment ◽  
Segment Length ◽  
Photoreceptor Outer Segment

Early cone photoreceptor outer segment length shortening in RPGR X-linked retinitis pigmentosa

2020 ◽  
Author(s):  
Moreno Menghini ◽  
Jasleen K. Jolly ◽  
Anika Nanda ◽  
Laura Wood ◽  
Jasmina Cehajic-Kapetanovic ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Outer Segment ◽  
Segment Length ◽  
Cone Photoreceptor ◽  
Photoreceptor Outer Segment

Photoreceptor Outer Segment Length: A Prognostic Factor for Idiopathic Epiretinal Membrane Surgery

Ophthalmology ◽  
2013 ◽  
Vol 120 (4) ◽  
pp. 788-794 ◽  
Author(s):  
Akira Shiono ◽  
Jiro Kogo ◽  
Gerd Klose ◽  
Hiroyuki Takeda ◽  
Hiroki Ueno ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Epiretinal Membrane ◽  
Outer Segment ◽  
Segment Length ◽  
Photoreceptor Outer Segment ◽  
Idiopathic Epiretinal Membrane

scholarly journals Choroidal thickness, ganglion cell complex and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

2019 ◽  
Author(s):  
Selim Bolukbasi ◽  
Ozge Kandemir Gursel ◽  
Akin Cakir ◽  
Burak Erden ◽  
Gamze Karatas
Keyword(s):  
Ganglion Cell ◽  
Choroidal Thickness ◽  
Outer Segment ◽  
Tamoxifen Therapy ◽  
Cell Complex ◽  
Segment Length ◽  
Ganglion Cell Complex ◽  
Photoreceptor Outer Segment ◽  
Tamoxifen Group ◽  
Sd Oct

Abstract Background To evaluate choroidal thickness, ganglion cell complex and photoreceptor outer segment length in patients with breast cancer undergoing tamoxifen therapy using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes. Methods Fourty four patients with breast cancer undergoing tamoxifen therapy and fourty one healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500 μm, 1000 μm, 1500 μm) and temporal (temporal distance to fovea 500 μm, 1000 μm, 1500 μm) choroidal thickness measurements were performed using enhanced depth imaging mode of SD-OCT. Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at the macular level, the automated retinal segmentation software was applied to determine thicknesses of the ganglion cell complex (GCC) by adding the macular retinal nerve fiber layer, macular ganglion cell layer, and macular internal plexiform layer parameters. The photoreceptor outer segment (PROS) length was determined by manually as the distance from inner surface of ellipsoid zone to inner surface of retina pigment epithelium after automatic retinal segmentation. Results The mean choroidal thickness measurements were statistically greater in tamoxifen group than controls in all quadrants (p<0.001 for all quadrants). Of all tamoxifen users (44 eyes of 44 patients), 33 eyes (75%) had uncomplicated pachychoroid (UCP). Pachychoroid pigment epitheliopathy (PPE) was detected in 5 patients (11.3%) in tamoxifen group. Patients with PPE in one eye had UCP in the fellow eye. Central serous chorioretinopathy findings were observed in one patient. Tamoxifen users had statistically lower GCC thicknesses in all inner rings of ETDRS inlay and only in nasal outer ring (p:0.027, p:0.002, p:0.002, p:0.001 and p:0.030; respectively). No statistically significant difference was found between the groups in terms of mean subfoveal PROS length. Conclusions SD-OCT provides valuable information in identifying the structural changes and evaluation of ocular findings in patients receiving tamoxifen therapy. Increasing choroidal thickness, PPE, thinning GCC were detected in tamoxifen users. These OCT findings may be an early indicator of retinal toxicity for patients undergoing tamoxifen therapy in follow-up period.

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