scholarly journals Forty‐eight hours of normothermic kidney preservation applying urine recirculation

2022 ◽  
Author(s):  
Annemarie Weissenbacher ◽  
Franka Messner ◽  
Silvia Gasteiger ◽  
Afschin Soleiman ◽  
Dietmar Öfner ◽  
...  
Keyword(s):  
Kidney Preservation

scholarly journals Optimizing porcine donor kidney preservation with normothermic or hypothermic machine perfusion: A systematic review

2021 ◽  
Author(s):  
Sarah Bouari ◽  
Özgür Eryigit ◽  
Ron W. F. Bruin ◽  
Jan N. M. IJzermans ◽  
Robert C. Minnee
Keyword(s):  
Systematic Review ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Kidney Preservation ◽  
Hypothermic Machine Perfusion

A SIMPLIFIED KIDNEY PRESERVATION SYSTEM: DEVELOPMENT AND INITIAL RESULTS

1973 ◽  
Vol 1 (2) ◽  
pp. 59-62 ◽  
Author(s):  
Geoffrey M. Collins ◽  
Ian R. Hardie ◽  
Gordon J. A. Clunie
Keyword(s):  
System Development ◽  
Kidney Preservation ◽  
Initial Results

Perfusion Pressure in Kidney Preservation

Nature ◽  
1968 ◽  
Vol 220 (5169) ◽  
pp. 794-795 ◽  
Author(s):  
B. STERRY ASHBY ◽  
FOLKERT O. BELZER
Keyword(s):  
Perfusion Pressure ◽  
Kidney Preservation

TRANSPORTABLE ORGAN-PERFUSION SYSTEM FOR KIDNEY PRESERVATION

The Lancet ◽  
1971 ◽  
Vol 298 (7739) ◽  
pp. 1403-1405 ◽  
Author(s):  
A.W. Moberg ◽  
E.A. Santiago ◽  
R.V. Mason ◽  
M.F. Mozes ◽  
R.A. Campos ◽  
...  
Keyword(s):  
Organ Perfusion ◽  
Perfusion System ◽  
Kidney Preservation

ULTRASTRUCTURE OF KIDNEY PRESERVATION

1983 ◽  
Vol 35 (2) ◽  
pp. 136-143 ◽  
Author(s):  
ALINE K. COFFEY ◽  
PETER M. ANDREWS
Keyword(s):  
Kidney Preservation

Metabolic Requirements for Successful Extended Hypothermic Kidney Preservation

1986 ◽  
Vol 136 (2) ◽  
pp. 345-350 ◽  
Author(s):  
David Anaise ◽  
Wayne C. Waltzer ◽  
Felix T. Rapaport
Keyword(s):  
Kidney Preservation

scholarly journals Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage

2013 ◽  
Vol 305 (7) ◽  
pp. F1022-F1030 ◽  
Author(s):  
Mandeep Singh ◽  
Dolapo T. Odeniyi ◽  
Eugene O. Apostolov ◽  
Alena Savenka ◽  
Todd Fite ◽  
...  
Keyword(s):  
Cell Death ◽  
Dna Fragmentation ◽  
Cold Storage ◽  
Ex Vivo ◽  
Rat Kidney ◽  
Maximum Effect ◽  
Kidney Preservation ◽  
Endonuclease G ◽  
Normal Rat ◽  
Rat Kidneys

Cold storage of kidneys before transplantation is problematic because of the limited survival time of the allografts. In this study, zinc- N-acetylcysteine (ZnNAC) was shown to be a potent endonuclease inhibitor and antioxidant, and it was tested as a potential additive to a cold storage solution for kidney preservation. Exposure of normal rat kidney NRK-52E cells to ZnNAC resulted in zinc delivery to the cells as determined by TFL-Zn fluorophore and partial protection of the cells against injury by cold storage in University of Wisconsin solution (UWS) as measured by propidium iodide assay. Ex vivo, rat kidneys demonstrated time- and temperature-dependent DNA fragmentation as assessed by TUNEL assay, indicating irreversible cell death. DNA fragmentation was faster in the medulla than in the cortex, and tubules were affected more than glomeruli. Perfusion of rat kidneys with cold ZnNAC solution in UWS significantly inhibited cell death both in the cortex and medulla at concentrations of 0.3–30 mM compared with UWS alone, with a maximum effect at 1–10 mM ZnNAC. Cold storage of the kidney significantly increased quantities of cleaved caspase-3 and endonuclease G (EndoG) in the tissue, which were abolished by 10 mM ZnNAC, indicating its ability to suppress both caspase-dependent and -independent cell death. Therefore, supplementation of UWS with ZnNAC can decrease DNA fragmentation and protect kidney allografts from cell death due to cold storage.

KIDNEY PRESERVATION FAILURE USING COMBINED COLLINS' SOLUTION AND PLASMA PERFUSION

1983 ◽  
Vol 36 (1) ◽  
pp. 24-25 ◽  
Author(s):  
ROBERT T. SCHWEIZER ◽  
BRUCE A. SUTPHIN
Keyword(s):  
Kidney Preservation
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