Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care –two case reports and review of the literature

Pendahuluan: Society of Critical Care Medicine (SCCM) dan European Society of Intensive Care Medicine (ESICM) mengeluarkan definisi sepsis terbaru (Sepsis-3) yaitu disfungsi organ yang mengancam jiwa akibat disregulasi respon imun pejamu terhadap infeksi. Skor Sequential Organ Failure Assessment (SOFA) telah dipilih dan divalidasi sebagai sistem penilaian untuk mengukur disfungsi organ dikarenakan skor SOFA pada pasien dewasa dengan kecurigaan infeksi, sebanding atau bahkan lebih unggul daripada sistem penilaian lainnya dalam membedakan mortalitas rumah sakit. Untuk mengadaptasi definisi Sepsis-3, skor SOFA diadaptasi dan divalidasi untuk pasien anak-anak yang mengidap sakit kritis (pSOFA) dengan menggunakan kriteria yang telah disesuaikan berdasarkan usia. Hasil penelitian menunjukan perkiraan mortalitas pada pSOFA saat waktu kedatangan, hari 2, 4, 7 dan 14 setelah masuk Pediatric Intensive Care Unit (PICU) lebih baik dibandingkan skor disfungsi organ lainnya. Evaluasi serial dari skor pSOFA pada hari pertama setelah masuk PICU juga sangat baik dalam memprediksi prognosis dari pasien pediatri onkologi yang memakai ventilator selama 3 hari, anak-anak dengan sepsis di PICU dan berguna untuk memprediksi mortalitas 30 hari pada populasi PICU, namun kurang berhasil dalam memprediksi lamanya pasien untuk dirawat di PICU.

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Diarrhea in the intensive care unit: the role of hypoalbuminemia and the response to a chemically defined diet (case reports and review of the literature).

Journal of the American College of Nutrition ◽

10.1080/07315724.1987.10720211 ◽

1987 ◽

Vol 6 (6) ◽

pp. 517-523 ◽

Cited By ~ 27

Author(s):

R R Brinson ◽

W D Curtis ◽

M Singh

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Case Reports ◽

Review Of The Literature

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341: SUCCESS OF RESPIRATORY RESCUE THERAPY IN PREVENTING REINTUBATION IN A PEDIATRIC INTENSIVE CARE UNIT

Critical Care Medicine ◽

10.1097/01.ccm.0000619720.74059.56 ◽

2020 ◽

Vol 48 (1) ◽

pp. 153-153

Author(s):

Ameer Al-Hadidi ◽

Morta Lapkus ◽

Patrick Karabon ◽

Ahmed Naseem ◽

Begum Akay ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Pediatric Intensive Care Unit ◽

Rescue Therapy ◽

Pediatric Intensive Care

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An outbreak of Pichia ohmeri infection in the paediatric intensive care unit: case reports and review of the literature

Mycoses ◽

10.1111/j.1439-0507.2005.01126.x ◽

2005 ◽

Vol 48 (4) ◽

pp. 265-269 ◽

Cited By ~ 33

Author(s):

Feza Otag ◽

Necdet Kuyucu ◽

Zayre Erturan ◽

Sebahat Sen ◽

Gurol Emekdas ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Paediatric Intensive Care Unit ◽

Case Reports ◽

Paediatric Intensive Care ◽

Review Of The Literature

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Hypophosphatemia in critically ill children

Revista do Hospital das Clínicas ◽

10.1590/s0041-87812004000500015 ◽

2004 ◽

Vol 59 (5) ◽

pp. 306-311 ◽

Cited By ~ 11

Author(s):

Fernanda Souza de Menezes ◽

Heitor Pons Leite ◽

Juliana Fernandez ◽

Silvana Gomes Benzecry ◽

Werther Brunow de Carvalho

Keyword(s):

Risk Factors ◽

Intensive Care ◽

Critically Ill ◽

Case Reports ◽

Clinical Manifestations ◽

Pediatric Intensive Care ◽

Cochrane Library ◽

Critically Ill Children ◽

Renal Diseases ◽

Bibliographic Databases

The purpose of this paper is to review clinical studies on hypophosphatemia in pediatric intensive care unit patients with a view to verifying prevalence and risk factors associated with this disorder. We searched the computerized bibliographic databases Medline, Embase, Cochrane Library, and LILACS to identify eligible studies. Search terms included critically ill, pediatric intensive care, trauma, sepsis, infectious diseases, malnutrition, inflammatory response, surgery, starvation, respiratory failure, diuretic, steroid, antiacid therapy, mechanical ventilation. The search period covered those clinical trials published from January 1990 to January 2004. Studies concerning endocrinological disorders, genetic syndromes, rickets, renal diseases, anorexia nervosa, alcohol abuse, and prematurity were not included in this review. Out of 27 studies retrieved, only 8 involved pediatric patients, and most of these were case reports. One clinical trial and one retrospective study were identified. The prevalence of hypophosphatemia exceeded 50%. The commonly associated factors in most patients with hypophosphatemia were refeeding syndrome, malnutrition, sepsis, trauma, and diuretic and steroid therapy. Given the high prevalence, clinical manifestations, and multiple risk factors, the early identification of this disorder in critically ill children is crucial for adequate replacement therapy and also to avoid complications.

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