scholarly journals In‐vitro Thrombogenicity Testing of Pulsatile Mechanical Circulatory Support Systems: Design and Proof‐of‐Concept

2021 ◽  
Author(s):  
Moritz K. Brockhaus ◽  
Mehdi J. Behbahani ◽  
Farina Muris ◽  
Sebastian V. Jansen ◽  
Thomas Schmitz‐Rode ◽  
...  
Keyword(s):  
Mechanical Circulatory Support ◽  
Support Systems ◽  
Systems Design ◽  
Circulatory Support ◽  
Proof Of Concept

Supraventricular tachycardia under mechanical circulatory support systems

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
H Welp ◽  
V Kösek ◽  
G Mönnig ◽  
A Hoffmeier ◽  
A Rukosujew ◽  
...  
Keyword(s):  
Supraventricular Tachycardia ◽  
Mechanical Circulatory Support ◽  
Support Systems ◽  
Circulatory Support

scholarly journals Mechanical circulatory support systems: evolution, the systems and outlook

2021 ◽  
Vol 11 (1) ◽  
pp. 309-322
Author(s):  
Roland Hetzer ◽  
Mariano Francisco del Maria Javier ◽  
Michael Dandel ◽  
Matthias Loebe ◽  
Eva Maria Javier Delmo
Keyword(s):  
Mechanical Circulatory Support ◽  
Support Systems ◽  
Circulatory Support

Hemolysis associated with Impella heart pump positioning: In vitro hemolysis testing and computational fluid dynamics modeling

2020 ◽  
Vol 43 (11) ◽  
pp. 710-718
Author(s):  
Nicholas Roberts ◽  
Uma Chandrasekaran ◽  
Soumen Das ◽  
Zhongwei Qi ◽  
Scott Corbett
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Dynamics Modeling ◽  
Computational Fluid Dynamics Modeling ◽  
Heart Pump ◽  
Mechanical Circulatory Support Devices ◽  
Support Devices

Introduction: Short-term mechanical circulatory support devices provide temporary hemodynamic support in heart failure and are increasingly used to enable recovery or as a bridge to decision. Blood damage with mechanical circulatory support devices is influenced by many factors, including the magnitude and duration of shear stress and obstruction to blood flow. This study aimed to evaluate the effects of the Impella CP® heart pump positioning on hemolysis using in vitro hemolysis testing and computational fluid dynamics modeling. Methods: The in vitro hemolysis testing was conducted per the recommended Food and Drug Administration and American Society for Testing and Materials guidelines. The bench hemolysis testing and computational fluid dynamics simulation analysis were performed for both normal operating (outlet unobstructed) and outlet-obstructed condition of Impella CP (mimicking outlet on the aortic valve due to improper positioning). Results: The modified index of hemolysis was 2.78 ± 0.69 at normal operating conditions compared to 18.7 ± 7.8 when the Impella CP outlet was obstructed ( p = 0.002). Computational fluid dynamics modeling showed about three times increase in exposure time to regions of high shear stress when the Impella CP outlet was obstructed compared to unobstructed condition, thus supporting the experimental observations. Conclusion: Based on these results, it is recommended to ensure proper placement of Impella CP via regular monitoring using echocardiographic guidance or other methods to minimize the risk of hemolysis associated with an obstructed outflow.

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