Artificial tissue creation under microgravity conditions: Considerations and future applications

2021 ◽  
Author(s):  
Vishal Swaminathan ◽  
Grace Bechtel ◽  
Vakhtang Tchantchaleishvili
AIAA Journal ◽  
2001 ◽  
Vol 39 ◽  
pp. 455-457 ◽  
Author(s):  
Yusaku Fujii ◽  
Hiroyuki Fujimoto ◽  
Ritsu Watanabe ◽  
Yukinobu Miki

1988 ◽  
Author(s):  
M. GLICKSMAN ◽  
R. HAHN ◽  
T. LOGRASSO ◽  
S. TIRMIZI ◽  
E. WINSA

1998 ◽  
Author(s):  
Andreas Alexandrou ◽  
Nikos Gatsonis ◽  
Hui Shi ◽  
Albert Sacco

Author(s):  
Lev G. D’YACHKOV ◽  
Mikhail M. VASILYEV ◽  
Oleg F. PETROV ◽  
Sergey F. SAVIN ◽  
Igor V. CHURILO

We discuss the possibility of using static magnetic traps as an alternative to electrostatic traps for forming and confining structures of charged dust particles in a gas discharge plasma in the context of our study of strongly interacting Coulomb systems. Some advantages of confining structures in magnetic traps over electrostatic ones are shown. Also we provide a review of the related researches carried out first in laboratory conditions, and then under microgravity conditions including the motivation of performing the experiments aboard the International Space Station (ISS). The preparations of a new space experiment «Coulomb-magnet» as well as the differences of a new equipment from previously used are described. We proposed the main tasks of the new experiment as a study of the dynamics and structure of active monodisperse and polydisperse macroparticles in an inhomogeneous magnetic field under microgravity conditions, including phase transitions and the evolution of such systems in the kinetic heating of dust particles by laser radiation. Key words: Coulomb structures, magnetic trap, antiprobotron, diamagnetic particles, dust particles, microgravity.


2018 ◽  
Vol 946 ◽  
pp. 012144 ◽  
Author(s):  
V N Naumkin ◽  
A M Lipaev ◽  
V I Molotkov ◽  
D I Zhukhovitskii ◽  
A D Usachev ◽  
...  

2001 ◽  
Vol 32 ◽  
pp. 941-942
Author(s):  
F. PRODI ◽  
F. DUBOIS ◽  
A.A. VEDERNIKOV ◽  
G. SANTACHIARA ◽  
C. CORNETTI ◽  
...  

2021 ◽  
Vol 12 (2) ◽  
pp. 30
Author(s):  
Shabir Hassan ◽  
Berivan Cecen ◽  
Ramon Peña-Garcia ◽  
Fernanda Roberta Marciano ◽  
Amir K. Miri ◽  
...  

Different strategies have been employed to provide adequate nutrients for engineered living tissues. These have mainly revolved around providing oxygen to alleviate the effects of chronic hypoxia or anoxia that result in necrosis or weak neovascularization, leading to failure of artificial tissue implants and hence poor clinical outcome. While different biomaterials have been used as oxygen generators for in vitro as well as in vivo applications, certain problems have hampered their wide application. Among these are the generation and the rate at which oxygen is produced together with the production of the reaction intermediates in the form of reactive oxygen species (ROS). Both these factors can be detrimental for cell survival and can severely affect the outcome of such studies. Here we present calcium peroxide (CPO) encapsulated in polycaprolactone as oxygen releasing microparticles (OMPs). While CPO releases oxygen upon hydrolysis, PCL encapsulation ensures that hydrolysis takes place slowly, thereby sustaining prolonged release of oxygen without the stress the bulk release can endow on the encapsulated cells. We used gelatin methacryloyl (GelMA) hydrogels containing these OMPs to stimulate survival and proliferation of encapsulated skeletal myoblasts and optimized the OMP concentration for sustained oxygen delivery over more than a week. The oxygen releasing and delivery platform described in this study opens up opportunities for cell-based therapeutic approaches to treat diseases resulting from ischemic conditions and enhance survival of implants under severe hypoxic conditions for successful clinical translation.


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