scholarly journals A bi‐centric experience of extracorporeal carbon dioxide removal (ECCO 2 R) for acute hypercapnic respiratory failure following allogeneic hematopoietic stem cell transplantation

2021 ◽  
Author(s):  
Philipp Wohlfarth ◽  
Peter Schellongowski ◽  
Thomas Staudinger ◽  
Werner Rabitsch ◽  
Alexander Hermann ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Stem Cell ◽  
Respiratory Failure ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Extracorporeal Carbon Dioxide Removal ◽  
Hematopoietic Stem ◽  
Hypercapnic Respiratory Failure ◽  
Acute Hypercapnic Respiratory Failure

HLA-haploidentical blood progenitor cell transplantation in osteopetrosis

Blood ◽  
2002 ◽  
Vol 99 (9) ◽  
pp. 3458-3460 ◽  
Author(s):  
Ansgar S. Schulz ◽  
Carl Friedrich Classen ◽  
Walther A. Mihatsch ◽  
Michael Sigl-Kraetzig ◽  
Markus Wiesneth ◽  
...  
Keyword(s):  
Stem Cell ◽  
Respiratory Failure ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Progenitor Cells ◽  
Cell Transplantation ◽  
Poor Prognosis ◽  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Graft Versus Host

Abstract Infantile osteopetrosis (OP) carries an extremely poor prognosis unless treated early by hematopoietic stem cell transplantation. We explored the use of purified blood progenitor cells from HLA-haploidentical parents in 7 patients lacking suitable matched donors. Blood progenitor cells were purified by positive selection and by additional T-cell depletion using rosette formation. For conditioning, patients received busulfan, thiotepa, and either cyclophosphamide (5 patients) or fludarabine (2 patients). Stable donor engraftment developed in 6 of 7 patients. Graft-versus-host disease was not observed. Three of the 7 patients had no major complications and 4 of 7 had both veno-occlusive disease and respiratory failure. Five of 7 patients survive with complete cure of OP at a median of 4 years. Patients with OP lacking HLA-matched donors can be successfully treated by transplantation of purified blood progenitor cells from HLA-haploidentical donors.

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