Rapid exchange of an Impella 5.0. for an Impella 5.5 through the same arterial axillary access

2021 ◽  
Author(s):  
Willem Gussinklo ◽  
Sameer Al‐Maisary
Keyword(s):  
Rapid Exchange

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides

2018 ◽  
Author(s):  
Christopher J. Smedley ◽  
Bing Gao ◽  
Suhua Li ◽  
Qinheng Zheng ◽  
Andrew Molino ◽  
...  
Keyword(s):  
Breast Cancer Cells ◽  
Catalytic Mechanism ◽  
Bioactive Molecules ◽  
Chromatographic Purification ◽  
Rapid Exchange ◽  
Nucleophilic Displacement ◽  
Sulfur Fluoride ◽  
Reactions With Nucleophiles ◽  
New Generation ◽  
Selection Of

Sulfur-Fluoride Exchange (SuFEx) is the new generation click chemistry transformation exploiting the unique properties of S-F bonds and their ability to undergo near-perfect reactions with nucleophiles. We report here the first SuFEx based protocol for the efficient synthesis of pharmaceutically important triflones and bis(trifluoromethyl)sulfur oxyimines from the corresponding sulfonyl fluorides and iminosulfur oxydifluorides, respectively. The new protocol involves the rapid exchange of the S-F bond with trifluoromethyltrimethylsilane (TMSCF<sub>3</sub>) upon activation with potassium bifluoride in anhydrous DMSO. The reaction tolerates a wide selection of substrates and proceeds under mild conditions without need for chromatographic purification. A tentative catalytic mechanism is proposed supported by DFT calculations, involving formation of the free trifluoromethyl anion followed by nucleophilic displacement of the S-F through a five-coordinate intermediate. The preparation of a benzothiazole derived bis(trifluoromethyl)sulfur oxyimine with cytotoxic selectivity for MCF7 breast cancer cells demonstrates the utility of this methodology for the late-stage functionalization of bioactive molecules.<br>

scholarly journals Rapid exchange of subunits of mammalian ornithine decarboxylase.

1994 ◽  
Vol 269 (5) ◽  
pp. 3155-3158
Author(s):  
C.S. Coleman ◽  
B.A. Stanley ◽  
R. Viswanath ◽  
A.E. Pegg
Keyword(s):  
Ornithine Decarboxylase ◽  
Rapid Exchange

scholarly journals Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein

1999 ◽  
Vol 4 (5) ◽  
pp. 705-714 ◽  
Author(s):  
Ravindra C. Gupta ◽  
Ewa Folta-Stogniew ◽  
Shawn O'Malley ◽  
Masayuki Takahashi ◽  
Charles M. Radding
Keyword(s):  
Dna Homology ◽  
Base Pairs ◽  
Rapid Exchange ◽  
Recombination Protein ◽  
Human Rad51

Nuclear Recoil Reactions in Organo-Manganese Compounds. V. —Mn(CO)5 Target Compounds

1971 ◽  
Vol 49 (12) ◽  
pp. 2175-2178 ◽  
Author(s):  
H. Jakubinek ◽  
S. C. Srinivasan ◽  
D. R. Wiles
Keyword(s):  
Thermal Dissociation ◽  
Nuclear Recoil ◽  
Radical Reactions ◽  
High Yield ◽  
Target Molecule ◽  
Product Spectrum ◽  
Rapid Exchange ◽  
Manganese Compounds ◽  
Very High

HMn(CO)5, DMn(CO)5, CH3Mn(CO)5, and C6H5Mn(CO)5 have been irradiated with neutrons and the product spectrum of 56Mn-containing molecules determined. The results show that H56Mn(CO)5 is formed in all cases: 21.0%, 23.6% from HMn(CO)5 and DMn(CO)5 targets, respectively, and 6.9% and 2.1% from CH3Mn(CO)5 and C6H5Mn(CO)5, respectively. Thus the yields are not in accord with the number of H atoms per target molecule. Preliminary experiments show that •*Mn(CO)5 exchanges rapidly with HMn(CO)5 and DMn(CO)5 and very slowly with CH3Mn(CO)5 and C6H5Mn(CO)5. It is deduced that the very high yield of H56Mn(CO)5 in HMn(CO)5 and DMn(CO)5 targets could arise from the rapid exchange, while the lower yields of H56Mn(CO)5 in other targets must likely come from radical reactions following thermal dissociation of the target molecule.

Accessibility of the Central Nervous Connectives of Anodonta Cygnea to a Compound of Large Molecular Weight

1972 ◽  
Vol 56 (2) ◽  
pp. 493-499
Author(s):  
N. J. LANE ◽  
J. E. TREHERNE
Keyword(s):  
Cell Layer ◽  
Extracellular Fluid ◽  
Water Soluble ◽  
Bathing Medium ◽  
Anodonta Cygnea ◽  
Rapid Exchange ◽  
Soluble Ions ◽  
Large Molecular Weight ◽  
Water Soluble Ions ◽  
Intercellular Clefts

1. Ultrastructural observations on the uptake of an exogenous tracer substance, horseradish peroxidase (M.W. 40,000), have shown that this large molecule can penetrate the neural lamella in intact cerebro-visceral connectives of the lamellibranch, Anodonta cygnea. 2. Peroxidase molecules were also observed to penetrate between the intercellular clefts formed by adjacent membranes of the underlying peripheral glial cell layer and to move extensively into the underlying extracellular spaces. 3. These observations confirm the results of previous electrophysiological, radioisotopic and ultrastructural investigations indicating that a relatively rapid exchange of water-soluble ions and molecules occurs between the blood, or bathing medium, and the extracellular fluid bathing the axon surfaces in intact connectives.

scholarly journals Rapid Exchange of Bound ADP on theStaphylococcus aureusReplication Initiation Protein DnaA

2009 ◽  
Vol 284 (49) ◽  
pp. 34201-34210 ◽  
Author(s):  
Kenji Kurokawa ◽  
Hikaru Mizumura ◽  
Tohru Takaki ◽  
Yumiko Ishii ◽  
Norikazu Ichihashi ◽  
...  
Keyword(s):  
Rapid Exchange

scholarly journals Absence of Rapid Exchange Component in a Low-Affinity Carrier Transport

1963 ◽  
Vol 46 (4) ◽  
pp. 721-731 ◽  
Author(s):  
Paul G. LeFevre ◽  
Keyword(s):  
Carrier Transport ◽  
Transport Model ◽  
Exchange Process ◽  
Tracer Uptake ◽  
Transport Systems ◽  
Human Red Blood Cells ◽  
Rapid Exchange ◽  
Carrier Mediated Transport ◽  
Net Uptake ◽  
High Concentrations

A previous study showed that human red blood cells equilibrate much less rapidly with D-glucose at moderately high concentrations than with C14-glucose added after the net movement is completed. This had been predicted from a simple reversible mobile-carrier mediated-transport model system suggested by the net monosaccharide transport kinetics in these cells, but is also consistent with the more complex models proposed for certain active transport systems to account for elevation of tracer fluxes of even low-affinity "substrates" when their trans-concentration is raised. The simple model predicts, however, that with any sugar showing a much lower apparent affinity for the reactive sites, such as D-ribose, this phenomenon would not be observed, and tracer equilibration should proceed at approximately the same rate as net uptake. The latter expectation was confirmed experimentally by analyses of the ribose, or radioactivity, content of washed red cells sampled serially during incubation with ribose or C14-ribose in the appropriate mixtures. The tracer ribose movement showed no evidence of a relatively rapid exchange component. The relative rapidity of glucose tracer uptake into cells preloaded with ordinary glucose may therefore more readily be attributed simply to depression of tracer efflux by competition for the saturated reactive sites, than to any action of the trans-concentration on the influx by way of a coupled exchange process.

Successful delivery of polytetrafluoroethylene-covered stent using rapid exchange guide extension catheter

2016 ◽  
Vol 32 (2) ◽  
pp. 142-145 ◽  
Author(s):  
Yoshihide Fujimoto ◽  
Norimasa Tonoike ◽  
Yoshio Kobayashi
Keyword(s):  
Covered Stent ◽  
Rapid Exchange

scholarly journals Using flushing rate to investigate spring-neap and spatial variations of gravitational circulation and tidal exchanges in an estuary

2010 ◽  
Vol 14 (8) ◽  
pp. 1465-1476 ◽  
Author(s):  
D. C. Shaha ◽  
Y.-K. Cho ◽  
G.-H. Seo ◽  
C.-S. Kim ◽  
K. T. Jung
Keyword(s):  
Neap Tide ◽  
Spring Tide ◽  
Vertical Mixing ◽  
River Estuary ◽  
Spatial Variations ◽  
Tidal Amplitude ◽  
Gravitational Circulation ◽  
Flushing Rate ◽  
Rapid Exchange ◽  
Dispersive Flux

Abstract. Spring-neap and spatial variations of gravitational circulation and tidal exchanges in the Sumjin River Estuary (SRE) were investigated using the flushing rate. The flushing rate was calculated between multiple estuarine segments and the adjacent bay to examine the spatial variation of two exchanges. The strength of gravitational circulation and tidal exchanges modulated significantly between spring and neap tides, where stratification alternated between well-mixed and highly-stratified conditions over the spring-neap cycle. Tide-driven dispersive flux of salt dominated over gravitational circulation exchange near the mouth during spring tide due to the larger tidal amplitude that caused well-mixed conditions and rapid exchange. In contrast, the central and inner regimes were found to be partially stratified during spring tide due to the reduction in tidal amplitude where both gravitational circulation and tidal exchanges were important in transporting salt. The combined contributions of two fluxes were also found during neap tide along the SRE due to the significant reduction in vertical mixing that accompanied strong stratification. Gravitational circulation exchange almost entirely dominated in transporting salt at the upstream end during spring and neap tides.

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