Hypothermic machine perfusion can safely prolong cold ischemia time in deceased donor kidney transplantation. A retrospective analysis on postoperative morbidity and graft function

2020 ◽  
Author(s):  
Gian Luigi Adani ◽  
Riccardo Pravisani ◽  
Patrizia Tulissi ◽  
Miriam Isola ◽  
Giacomo Calini ◽  
...  
Keyword(s):  
Postoperative Morbidity ◽  
Graft Function ◽  
Deceased Donor ◽  
Cold Ischemia Time ◽  
Cold Ischemia ◽  
Donor Kidney ◽  
Hypothermic Machine Perfusion ◽  
Deceased Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

scholarly journals Number of Donor Renal Arteries and Early Outcomes After Deceased Donor Kidney Transplantation

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0005152021
Author(s):  
S. Ali Husain ◽  
Kristen L. King ◽  
Shelief Robbins-Juarez ◽  
Joel T. Adler ◽  
Kasi R. McCune ◽  
...  
Keyword(s):  
Graft Failure ◽  
Graft Function ◽  
Deceased Donor ◽  
Renal Arteries ◽  
Delayed Graft Function ◽  
Cold Ischemia ◽  
Donor Kidney ◽  
Deceased Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

Background: Anatomical abnormalities increase the risk of deceased donor kidney discard but their impact on transplant outcomes is understudied. We sought to determine the impact of multiple donor renal arteries on early outcomes after deceased donor kidney transplantation. Methods: For this retrospective cohort study, we identified 1443 kidneys from 832 deceased donors with ≥1 kidney transplanted at our center (2006-2016). We compared the odds of delayed graft function and 90-day graft failure using logistic regression. To reduce potential selection bias, we then repeated the analysis using a paired-kidney cohort including kidney pairs from 162 donors with 1 single-artery kidney and 1 multi-artery kidney. Results: Of 1443 kidneys included, 319 (22%) had multiple arteries. Multi-artery kidneys experienced longer cold ischemia time, but other characteristics were similar between groups. Delayed graft function (50% multi-artery vs 45% one artery, p=0.07) and 90-day graft failure (3% vs 3%, p=0.83) were similar between groups before and after adjusting for donor and recipient characteristics. In the paired kidney analysis, cold ischemia time was significantly longer for multi-artery kidneys compared to single-artery kidneys from the same donor (33.5 versus 26.1 hours, p<0.001), but delayed graft function and 90-day graft failure were again similar between groups. Conclusions: Compared to single-artery deceased donor kidneys, those with multiple renal arteries are harder to place but experience similar delayed graft function and early graft failure.

scholarly journals Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation

2019 ◽  
Vol 5 (5) ◽  
pp. e448 ◽  
Author(s):  
Hessel Peters-Sengers ◽  
Julia H.E. Houtzager ◽  
Mirza M. Idu ◽  
Martin B.A. Heemskerk ◽  
Ernst L.W. van Heurn ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Deceased Donor ◽  
Cold Ischemia Time ◽  
Cold Ischemia ◽  
Donor Kidney ◽  
Ischemia Time ◽  
Deceased Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

scholarly journals Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Rao Chen ◽  
Haifeng Wang ◽  
Lei Song ◽  
Jianfei Hou ◽  
Jiawei Peng ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Graft Function ◽  
Deceased Donor ◽  
Donor Kidney ◽  
Ischemic Time ◽  
Deceased Donor Kidney ◽  
One Year ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

Abstract Background Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. Methods This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors. Results The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P < 0.05). Conclusion The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.

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