A 3‐dimensional‐printed left ventricle model incorporated into a mock circulatory loop to investigate hemodynamics inside a severely failing ventricle supported by a blood pump

2020 ◽  
Author(s):  
Guang‐Mao Liu ◽  
Jian‐Feng Hou ◽  
Run‐Jie Wei ◽  
Sheng‐Shou Hu
Keyword(s):  
Left Ventricle ◽  
Blood Pump ◽  
3 Dimensional ◽  
Left Ventricle Model

Intraventricular flow visualization in different heart failure stages with blood pump support in a mock circulatory loop

2021 ◽  
pp. 039139882110214
Author(s):  
Guang-Mao Liu ◽  
Fu-Qing Jiang ◽  
Jiang-Ping Song ◽  
Sheng-Shou Hu
Keyword(s):  
Heart Failure ◽  
Standard Deviation ◽  
Aortic Valve ◽  
Left Ventricle ◽  
Left Ventricular ◽  
Blood Pump ◽  
Blood Damage ◽  
Intraventricular Flow ◽  
Pump Inlet ◽  
Strong Vorticity

The intraventricular blood flow changed by blood pump flow dynamics may correlate with thrombosis and ventricular suction. The flow velocity, distribution of streamlines, vorticity, and standard deviation of velocity inside a left ventricle failing to different extents throughout the cardiac cycle when supported by an axial blood pump were measured by particle image velocimetry (PIV) in this study. The results show slower and static flow velocities existed in the central region of the left ventricle near the mitral valve and aortic valve and that were not sensitive to left ventricular (LV) failure degree or LV pressure. Strong vorticity located near the inner LV wall around the LV apex and the blood pump inlet was not sensitive to LV failure degree or LV pressure. Higher standard deviation of the blood velocity at the blood pump inlet decreased with increasing LV failure degree, whereas the standard deviation of the velocity near the atrium increased with increasing intraventricular pressure. The experimental results demonstrated that the risk of thrombosis inside the failing left ventricle is not related to heart failure degree. The “washout” performance of the strong vorticity near the inner LV wall could reduce the thrombotic potential inside the left ventricle and was not related to heart failure degree. The vorticity near the aortic valve was sensitive to LV failure degree but not to LV pressure. We concluded that the risk of blood damage caused by adverse flow inside the left ventricle decreased with increasing LV pressure.

scholarly journals Sensitivity Analysis of a Left Ventricle Model in the Context of Intraventricular Dyssynchrony

2019 ◽  
Vol 68 (1) ◽  
pp. 45-59 ◽  
Author(s):  
Virginie Le Rolle ◽  
Elena Galli ◽  
David Danan ◽  
Karim El Houari ◽  
Arnaud Hubert ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Left Ventricle ◽  
Intraventricular Dyssynchrony ◽  
Left Ventricle Model

J0206-2-4 Simulation of Left Ventricle Model by Cardiomyocyte Simulator and Eulerian based Fluid-Structure Analysis

2010 ◽  
Vol 2010.6 (0) ◽  
pp. 91-92
Author(s):  
Kiyoshi Kumahata ◽  
Koji Nishiguchi ◽  
Shigenobu Okazawa ◽  
Akira Amano ◽  
Teruo Matsuzawa
Keyword(s):  
Left Ventricle ◽  
Structure Analysis ◽  
Fluid Structure ◽  
Left Ventricle Model

scholarly journals A coupled mitral valve—left ventricle model with fluid–structure interaction

2017 ◽  
Vol 47 ◽  
pp. 128-136 ◽  
Author(s):  
Hao Gao ◽  
Liuyang Feng ◽  
Nan Qi ◽  
Colin Berry ◽  
Boyce E. Griffith ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Left Ventricle ◽  
Fluid Structure Interaction ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Left Ventricle Model

Transthoracic 3-dimensional echocardiography in the assessment of subaortic stenosis due to a restrictive ventricular septal defect in double inlet left ventricle with discordant ventriculoarterial connections

1999 ◽  
Vol 9 (6) ◽  
pp. 549-555 ◽  
Author(s):  
Michael Vogel ◽  
S. Yen Ho ◽  
Robert H. Anderson ◽  
Andrew N. Redingtont
Keyword(s):  
Aortic Valve ◽  
Left Ventricle ◽  
Ventricular Septal Defect ◽  
Cross Section ◽  
Septal Defect ◽  
Subaortic Stenosis ◽  
3 Dimensional ◽  
En Face ◽  
Dimensional Echocardiography ◽  
Double Inlet Left Ventricle

AbstractTo evaluate the accuracy and clinical utility of three-dimensional echocardiography in the assessment of the size and shape of the ventricular septal defect in double inlet left ventricle.MethodsWe validated the technique in an autopsy study, and then performed a clinical investigation. Six autopsied hearts were immersed in a waterbath and examined with 3-dimensional echocardiography. We identified the cross-section within the dataset which optimally displayed the ventricular septal defect “en face”, and compared its smallest and largest diameters, as well as its area. The ventricular septal defect was then filled with a silicone sealant and a section prepared for direct measurement. In patients, we measured the diameters and area of the ventricular septal defect in endsystole nad computed the aortic valvar area in endsystole from the cross-section showing the aortic valve “en face”. Ten patients with double inlet left ventricle, aged between 2 and 15 years, were studied using rotational or parallel scanning. All patients had undergone banding of the pulmonary trunk at a mean age of 7 (3–36) days, usually at the time of repair of the coarctation. Two patients had undergone surgical enlargement of the ventricular septal defect prior to echocardiographic examination.ResultsThe correlation between the areas of the ventricular septal defect in the specimens measured directly and by 3-dimensional echocardiography was r=0.98, with limits of agreement between −0.1– 0.08 cm2. In the patients, the area of the defect was measured as 3.9±2 cm2, whereas the aortic valvar area was 2.6±0.9 cm2. The ratio between the areas was 1.5 (0.5–2.3). Three patients with areas of the ventricular septal defect smaller than those of the aortic valve had resting Doppler gradients between double inlet left ventricle and the aorta of 16, 20 and 30 mm Hgs, respectively.Conclusions3-dimensional echocardiography provides accurate assessment of the area of the ventricular septal defect in double inlet left ventricle, and is helpful in identifying patients with subaortic stenosis caused by restrictive defects.

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