scholarly journals Comparison between standard single chamber versus dual chamber low glucose degradation product peritoneal dialysis fluids

2020 ◽  
Author(s):  
Kornchanok Vareesangthip ◽  
Surachet Vongsanim ◽  
Stanley Fan ◽  
Andrew Davenport
Keyword(s):  
Peritoneal Dialysis ◽  
Degradation Product ◽  
Dual Chamber ◽  
Single Chamber ◽  
Low Glucose ◽  
Dialysis Fluids ◽  
Glucose Degradation Product

Neutral pH and low–glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis

2018 ◽  
Vol 94 (2) ◽  
pp. 419-429 ◽  
Author(s):  
Betti Schaefer ◽  
Maria Bartosova ◽  
Stephan Macher-Goeppinger ◽  
Peter Sallay ◽  
Peter Vörös ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Degradation Product ◽  
Peritoneal Membrane ◽  
Neutral Ph ◽  
Low Glucose ◽  
Dialysis Fluids ◽  
Glucose Degradation Product

The Effect of Low Glucose Degradation Product Dialysis Solution on Epithelial-To-Mesenchymal Transition in Continuous Ambulatory Peritoneal Dialysis Patients

2005 ◽  
Vol 25 (3_suppl) ◽  
pp. 22-25 ◽  
Author(s):  
Jun-Young Do ◽  
Yong-Lim Kim ◽  
Jong-Won Park ◽  
Kyu-Hyang Cho ◽  
Tae-Woo Kim ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Degradation Product ◽  
Cultured Cells ◽  
Enzyme Inhibitor ◽  
Controlled Study ◽  
Membrane Function ◽  
Mesenchymal Transition ◽  
Dialysis Solution ◽  
Low Glucose ◽  
Glucose Degradation Product

♦ Background Human peritoneal mesothelial cells (HPMCs) undergo a transition from an epithelial phenotype to a mesenchymal phenotype (EMT) during peritoneal dialysis (PD). That transition may be directly related to failure of peritoneal membrane function. ♦ Objective In a randomized prospective controlled study, we investigated the effect of low glucose degradation product (GDP) dialysis solution on the transition of HPMCs. ♦ Methods Among new continuous ambulatory PD patients, 60 patients completed a 12-month protocol (low-GDP solution group, n = 32; high-GDP solution group, n = 28). At the 1st, 6th, and 12th months, HPMCs drained from overnight effluent were cultured on T25. When they had nearly reached confluence, cell scores were measured blindly by the same person (score 1 = cobblestone-shaped HPMCs, score 2 = mixed, score 3 = fibroblast dominant). Cell scores and clinical indices, including peritoneal markers, were compared between the low-GDP and high-GDP groups at the 1st, 6th, and 12th months. The factors associated with EMT were analyzed with generalized estimating equations using STATA 7.0 (STATA Corp., College Station, Texas, USA). In addition, vimentin and cytokeratin 8/18 stains were used to verify EMT in cultured cells and peritoneal specimens in some patients. ♦ Results ( 1 ) The low-GDP group showed higher dialysate cancer antigen 125 levels from the 1st to 12th months (55.4 ± 24.8 vs 8.8 ± 1.7, 56.7 ± 28.1 vs 22.1 ± 11.3, and 54.2 ± 28.2 vs 24.6 ± 16.5 U/mL, at the 1st, 6th, and 12th months, respectively; all p = 0.000). ( 2 ) The low-GDP group showed lower cell scores at the 1st, 6th, and 12th months (1.22, 1.22, and 1.56 vs 1.61, 1.75, and 2.14; p < 0.05, p < 0.01, and p < 0.01, respectively). ( 3 ) At the 12th month, the number of fibroblast-dominant cultures (score 3) was significantly lower in the low-GDP group [4/32 (12.5%) patients vs 14/28 (50%), p < 0.05]. ( 4 ) Both cobblestone-shaped HPMCs and fibroblastoid cells were positively stained with cytokeratin and vimentin. ( 5 ) There were many cytokeratin- and vimentin-positive cells in the submesothelial area in the peritoneal biopsy specimens. (6) The consistent factor associated with EMT was only high-GDP solution (60 patients, n = 178, beta coefficient 0.312, p = 0.000; 46 patients, n = 137, beta coef: 0.228, p = 0.000) and not numbers of peritonitis episodes, duration of angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker medication, or diabetes. ♦ Conclusion Low-GDP solution showed beneficial effects such as rapid remesothelialization and less EMT in the peritoneum with time on PD.

Identification and quantification of the glucose degradation product glucosone in peritoneal dialysis fluids by HPLC/DAD/MSMS

2010 ◽  
Vol 878 (11-12) ◽  
pp. 877-882 ◽  
Author(s):  
Stefan Mittelmaier ◽  
Michael Fünfrocken ◽  
Dominik Fenn ◽  
Thomas Fichert ◽  
Monika Pischetsrieder
Keyword(s):  
Peritoneal Dialysis ◽  
Degradation Product ◽  
Dialysis Fluids ◽  
Glucose Degradation Product ◽  
Identification And Quantification
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