An advanced mock circulation loop for in vitro cardiovascular device evaluation

2020 ◽  
Vol 44 (6) ◽  
Author(s):  
Shaun D. Gregory ◽  
Jo P. Pauls ◽  
Eric L. Wu ◽  
Andrew Stephens ◽  
Ulrich Steinseifer ◽  
...  
Keyword(s):  
Circulation Loop ◽  
Mock Circulation ◽  
Mock Circulation Loop

A Compact Mock Circulation Loop for the In Vitro Testing of Cardiovascular Devices

2010 ◽  
Vol 35 (4) ◽  
pp. 384-391 ◽  
Author(s):  
Daniel L. Timms ◽  
Shaun D. Gregory ◽  
Nicholas A. Greatrex ◽  
Mark J. Pearcy ◽  
John F. Fraser ◽  
...  
Keyword(s):  
Circulation Loop ◽  
In Vitro Testing ◽  
Cardiovascular Devices ◽  
Mock Circulation ◽  
Mock Circulation Loop

A Mock Circulation Loop for In Vitro Hemodynamic Evaluation of Aorta: Application in Aortic Dissection

2021 ◽  
pp. 152660282110348
Author(s):  
Duanduan Chen ◽  
Shichao Liang ◽  
Zhenfeng Li ◽  
Yuqian Mei ◽  
Huiwu Dong ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
False Lumen ◽  
Peripheral Resistance ◽  
Flow Distribution ◽  
Circulation Loop ◽  
Patient Specific ◽  
Mock Circulation ◽  
Blood Transport ◽  
Mock Circulation Loop

Purpose Aortic dissection (AD) is a catastrophic disease with complex hemodynamic conditions, however, understandings regarding its perfusion characteristics were not sufficient. In this study, a mock circulation loop (MCL) that integrated the Windkessel element and patient-specific silicone aortic phantoms was proposed to reproduce the aortic flow environment in vitro. Materials and Methods Patient-specific normal and dissected aortic phantoms with 12 branching vessels were established and embedded into this MCL. Velocities for aortic branches based on 20 healthy volunteers were regarded as the standardized data for flow division. By altering boundary conditions, the proposed MCL could mimic normal resting and left-sided heart failure (LHF) conditions. Flow rates and pressure status of the aortic branches could be quantified by separate sensors. Results In normal resting condition, the simulated heart rate and systemic flow rate were 60 bpm and 4.85 L/minute, respectively. For the LHF condition, the systolic and diastolic blood pressures were 75.94±0.77 mmHg and 57.65±0.35 mmHg, respectively. By tuning the vascular compliance and peripheral resistance, the flow distribution ratio (FDR) of each aortic branch was validated by the standardized data in the normal aortic phantom (mean difference 2.4%±1.70%). By comparing between the normal and dissected aortic models under resting condition, our results indicated that the AD model presented higher systolic (117.82±0.60 vs 108.75±2.26 mmHg) and diastolic (72.38±0.58 vs 70.46±2.33 mmHg) pressures, the time-average velocity in the true lumen (TL; 36.95 cm/s) was higher than that in the false lumen (FL; 22.95 cm/s), and the blood transport direction between the TL and FL varied in different re-entries. Conclusions The proposed MCL could be applied as a research tool for in vitro hemodynamic analysis of the aorta diseases under various physical conditions.

scholarly journals Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
David G. Platts ◽  
Nicole Bartnikowski ◽  
Shaun D. Gregory ◽  
Gregory M. Scalia ◽  
John F. Fraser
Keyword(s):  
Signal Intensity ◽  
Continuous Flow ◽  
Ventricular Assist Devices ◽  
Circulation Loop ◽  
Relative Reduction ◽  
Ventricular Assist ◽  
Pump Speed ◽  
Mock Circulation ◽  
Mock Circulation Loop

Objectives. Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD). However imaging can be difficult in these patients. Contrast improves image quality but they are hydrodynamically fragile agents. The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL). Methods. Heartware continuous flow (CF) VAD was incorporated into a MCL. Definity® contrast was infused into the MCL with imaging before and after CF-VAD. 5 mm2 regions of interest were used to obtain signal intensity (decibels), as a surrogate of contrast concentration. Results. Four pump speeds revealed significant reduction in contrast signal intensity after CF-VAD compared to before CF-VAD (all p<0.0001). Combined pre- and postpump data at all speeds showed a 22.2% absolute reduction in contrast signal intensity across the CF-VAD (14.8 ± 0.8 dB prepump versus 11.6 ± 1.4 dB postpump; p<0.0001). Mean signal intensity reduction at each speed showed an inverse relationship between speed and relative reduction in signal intensity. Conclusion. Contrast microsphere transit through a CF-VAD within a MCL resulted in significant reduction in signal intensity, consistent with destruction within the pump. This was evident at all CF-VAD pump speeds but relative signal drop was inversely proportional to pump speed.

Software controlled mock circulation loop for validation of tah and vad controls

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
OAN Holtmannspötter ◽  
T Finocchiaro ◽  
R Autschbach ◽  
J Spillner
Keyword(s):  
Circulation Loop ◽  
Mock Circulation ◽  
Mock Circulation Loop
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