scholarly journals Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration

2018 ◽  
Vol 42 (8) ◽  
pp. E186-E203 ◽  
Author(s):  
Toshihiko Matsuo ◽  
Tetsuya Uchida ◽  
Jun Sakurai ◽  
Koichiro Yamashita ◽  
Chie Matsuo ◽  
...  
Keyword(s):  
Thin Film ◽  
Macular Degeneration ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Retinal Prosthesis ◽  
Photoelectric Dye ◽  
Visual Evoked

scholarly journals Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toshihiko Matsuo ◽  
Tetsuya Uchida
Keyword(s):  
Thin Film ◽  
Macular Degeneration ◽  
Surface Potential ◽  
Biological Evaluation ◽  
Retinal Prosthesis ◽  
Displacement Current ◽  
Vitreous Surgery ◽  
Artificial Retina ◽  
Retinal Tissue ◽  
Photoelectric Dye

We have developed the world's first novel type of artificial retina, OUReP (Okayama University Retinal Prosthesis), in which a photoelectric dye that converts light energy into electric potential is covalently bonded to the surface of a polyethylene thin film as an insulator. The receptor that absorbs light and the output device that generates displacement current to stimulate nearby neurons are integrated in a sheet of thin film. It has become possible to measure the surface potential of the artificial retina OUReP using a Kelvin probe that measures the surface potential of semiconductors. When light is turned on and off to the artificial retina OUReP, the surface potential changes rapidly. As the light intensity is increased, the potential change on the surface of the artificial retina becomes larger. As for safety, the artificial retina OUReP was not toxic in all tests for biological evaluation of medical devices. As for efficacy, the artificial retina OUReP was implanted under the retina by vitreous surgery in monkey eyes which had chemically-induced macular degeneration with photoreceptor cell loss. Over the next 6 months, retinal detachment did not occur during the course, and the artificial retina was in contact with the retinal tissue. The amplitude of the visual evoked potential attenuated by macular degeneration recovered 1 month after implantation of the artificial retina, and the recovery of amplitude was maintained until 6 months after the implantation. By using multielectrode array-mounted dish recording system, it has been proved that action potential spikes are induced when the artificial retina is placed on degenerative retinal tissue of retinal dystrophic rats or mice and exposed to light, which is used as an index of the effectiveness of the artificial retina. We have established manufacturing and quality control of the device in a clean room facility, proved the safety and efficacy, and are preparing for first-in-human investigator-initiated clinical trials.

scholarly journals Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama University-type retinal prosthesis (OURePTM)

2018 ◽  
Vol 80 (2) ◽  
pp. 247-259 ◽  
Author(s):  
Toshihiko MATSUO ◽  
Tetsuya UCHIDA ◽  
Koichiro YAMASHITA ◽  
Shigiko TAKEI ◽  
Daisuke IDO ◽  
...  
Keyword(s):  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Retinal Prosthesis ◽  
Visual Evoked

Olfactory Modulation of Steady- State Visual Evoked Potential Topography in Comparison with Differences in Odor Sensitivity

2002 ◽  
Vol 16 (2) ◽  
pp. 71-81 ◽  
Author(s):  
Caroline M. Owen ◽  
John Patterson ◽  
Richard B. Silberstein
Keyword(s):  
Steady State ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Behavioral Responses ◽  
Simultaneous Recording ◽  
Odor Concentration ◽  
Odor Detection ◽  
Detection Response ◽  
Response Groups ◽  
Visual Evoked

Summary Research was undertaken to determine whether olfactory stimulation can alter steady-state visual evoked potential (SSVEP) topography. Odor-air and air-only stimuli were used to determine whether the SSVEP would be altered when odor was present. Comparisons were also made of the topographic activation associated with air and odor stimulation, with the view toward determining whether the revealed topographic activity would differentiate levels of olfactory sensitivity by clearly identifying supra- and subthreshold odor responses. Using a continuous respiration olfactometer (CRO) to precisely deliver an odor or air stimulus synchronously with the natural respiration, air or odor (n-butanol) was randomly delivered into the inspiratory airstream during the simultaneous recording of SSVEPs and subjective behavioral responses. Subjects were placed in groups based on subjective odor detection response: “yes” and “no” detection groups. In comparison to air, SSVEP topography revealed cortical changes in response to odor stimulation for both response groups, with topographic changes evident for those unable to perceive the odor, showing the presence of a subconscious physiological odor detection response. Differences in regional SSVEP topography were shown for those who reported smelling the odor compared with those who remained unaware of the odor. These changes revealed olfactory modulation of SSVEP topography related to odor awareness and sensitivity and therefore odor concentration relative to thresholds.

Visual Evoked potential signal processing and analysis for normal and galucomic eyes

2015 ◽  
Vol 8 (2) ◽  
pp. 2106-2121
Author(s):  
Hamed Ibrahem Abdelkader ◽  
Mona Abdelkader ◽  
Mohammed Kabeel ◽  
Malak Alya
Keyword(s):  
Evoked Potentials ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Optic Tract ◽  
Pattern Reversal ◽  
Blue Color ◽  
Check Size ◽  
Retinal Stimulation ◽  
Normal Individuals ◽  
Visual Evoked

Visual evoked potentials (VEPS) are obtained from optic tract by recording the evoked potentials generated by retinal stimulation. The flash VEP (FVEP) is used less frequently than pattern reversal VEP (PRVEP) because; it shows great variation in both latency and amplitude. The present study was undertaken to evaluate the effect of change of wavelength of flash and change of check size on the parameters of visual evoked potential (amplitude and latency) in normal individuals and glaucoma patients. The group of healthy subjects in the age of 20-45 years while the group of glaucoma subjects where  in the age of 25-50 years.  The two groups were exposed to flash VEP with white light and blue color and they also were exposed to checks subtending a visual angles of 15, 30,60 and 120 minutes of arc. The measured data were statistically analyzed and summarized by histograms. The interindividual and intraindividual in latencies and amplitudes for FVEP were assessed using  the coefficient of variation (COV). In conclusion, monochromatic flash VEP was preferred than white as there were minimal inter and intra individual variation of latencies and amplitudes. The most preferred check size in PRVEP was 120' for  the two groups.  

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