Creatinine, Neutrophil Gelatinase-Associated Lipocalin, and Cystatin C in Determining Acute Kidney Injury After Heart Operations Using Cardiopulmonary Bypass

2016 ◽  
Vol 41 (5) ◽  
pp. 481-489 ◽  
Author(s):  
Jurij Matija Kališnik ◽  
Eva Hrovat ◽  
Alenka Hrastovec ◽  
Janez Žibert ◽  
Aleš Jerin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiopulmonary Bypass ◽  
Cystatin C ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome

Pathogens ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 666 ◽  
Author(s):  
Magnus Hansson ◽  
Rasmus Gustafsson ◽  
Chloé Jacquet ◽  
Nedia Chebaane ◽  
Simon Satchell ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Hemorrhagic Fever ◽  
Roc Curve Analysis ◽  
Abrupt Decrease ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Puumala orthohantavirus causes hemorrhagic fever with renal syndrome (HFRS) characterized by acute kidney injury (AKI), an abrupt decrease in renal function. Creatinine is routinely used to detect and quantify AKI; however, early AKI may not be reflected in increased creatinine levels. Therefore, kidney injury markers that can predict AKI are needed. The potential of the kidney injury markers urea, cystatin C, α1-microglobulin (A1M) and neutrophil gelatinase-associated lipocalin (NGAL) to detect early AKI during HFRS was studied by quantifying the levels of these markers in consecutively obtained plasma (P) and urine samples (U) for 44 HFRS patients. P-cystatin C and U-A1M levels were significantly increased during early HFRS compared to follow-up. In a receiver operating characteristic (ROC) curve analysis, P-cystatin C, U-A1M and P-urea predicted severe AKI with area under the curve 0.72, 0.73 and 0.71, respectively, whereas the traditional kidney injury biomarkers creatinine and U-albumin did not predict AKI. Nearly half of the HFRS patients (41%) fulfilled the criteria for shrunken pore syndrome, which was associated with the level of inflammation as measured by P-CRP. P-cystatin C and U-A1M are more sensitive and earlier markers compared to creatinine in predicting kidney injury during HFRS.

Sign in / Sign up

Export Citation Format

Share Document