Promotion of Full-Thickness Wound Healing Using Epigallocatechin-3-O-Gallate/Poly (Lactic-Co-Glycolic Acid) Membrane as Temporary Wound Dressing

2013 ◽  
Vol 38 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Hye-Lee Kim ◽  
Jeong-Hyun Lee ◽  
Byeong Ju Kwon ◽  
Mi Hee Lee ◽  
Dong-Wook Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Glycolic Acid ◽  
Full Thickness ◽  
Full Thickness Wound

Generation of Nano-pores in Silk Fibroin Films Using Silk Nanoparticles for Full-Thickness Wound Healing

2021 ◽  
Vol 22 (2) ◽  
pp. 546-556
Author(s):  
Jian Liu ◽  
Ran Huang ◽  
Gang Li ◽  
David L. Kaplan ◽  
Zhaozhu Zheng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Full Thickness ◽  
Full Thickness Wound

A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration

2021 ◽  
Author(s):  
Hao Li ◽  
Mengna Li ◽  
Pei Liu ◽  
Kai-Yang Wang ◽  
Haoyu Fang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Full Thickness ◽  
Matrix Deposition ◽  
Chitosan Hydrochloride ◽  
Reconstructive Microsurgery ◽  
Extracellular Matrix Deposition ◽  
Advanced Biomaterials ◽  
Native Skin ◽  
Full Thickness Wound

Due to the native skin limitations and the complexity of reconstructive microsurgery, advanced biomaterials are urgently required to promote wound healing for severe skin defects caused by accidents and disasters....

scholarly journals Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2554
Author(s):  
Marek Konop ◽  
Anna K. Laskowska ◽  
Mateusz Rybka ◽  
Ewa Kłodzińska ◽  
Dorota Sulejczak ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Diabetic Mice ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Impaired Wound Healing

Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. In this study, we evaluated an insoluble fraction of keratin containing casomorphin as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. Casomorphin, an opioid peptide with analgesic properties, was incorporated into keratin and shown to be slowly released from the dressing. An in vitro study showed that keratin-casomorphin dressing is biocompatible, non-toxic, and supports cell growth. In vivo experiments demonstrated that keratin-casomorphin dressing significantly (p < 0.05) accelerates the whole process of skin wound healing to the its final stage. Wounds covered with keratin-casomorphin dressing underwent reepithelization faster, ending up with a thicker epidermis than control wounds, as confirmed by histopathological and immunohistochemical examinations. This investigated dressing stimulated macrophages infiltration, which favors tissue remodeling and regeneration, unlike in the control wounds in which neutrophils predominated. Additionally, in dressed wounds, the number of microhemorrhages was significantly decreased (p < 0.05) as compared with control wounds. The dressing was naturally incorporated into regenerating tissue during the wound healing process. Applied keratin dressing favored reconstruction of more regular skin structure and assured better cosmetic outcome in terms of scar formation and appearance. Our results have shown that insoluble keratin wound dressing containing casomorphin supports skin wound healing in diabetic mice.

Bioactive antibacterial bilayer PCL/gelatin nanofibrous scaffold promotes full-thickness wound healing

2020 ◽  
Vol 583 ◽  
pp. 119413 ◽  
Author(s):  
Arman Jafari ◽  
Armin Amirsadeghi ◽  
Shadi Hassanajili ◽  
Negar Azarpira
Keyword(s):  
Wound Healing ◽  
Nanofibrous Scaffold ◽  
Full Thickness ◽  
Full Thickness Wound

scholarly journals Porcine cholecyst–derived scaffold promotes full-thickness wound healing in rabbit

2013 ◽  
Vol 4 ◽  
pp. 204173141351806 ◽  
Author(s):  
Deepa Revi ◽  
Vadavanath Prabhakaran Vineetha ◽  
Jaseer Muhamed ◽  
Akhila Rajan ◽  
Thapasimuthu Vijayamma Anilkumar
Keyword(s):  
Wound Healing ◽  
Full Thickness ◽  
Full Thickness Wound

scholarly journals Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model

2018 ◽  
Vol 191 (1) ◽  
pp. 167-176 ◽  
Author(s):  
Vincent Coger ◽  
Nina Million ◽  
Christoph Rehbock ◽  
Bernd Sures ◽  
Milen Nachev ◽  
...  
Keyword(s):  
Wound Healing ◽  
Rodent Model ◽  
Full Thickness ◽  
Tissue Concentrations ◽  
Iron Copper ◽  
Full Thickness Wound

Effects of Carbon Arc Lamp Irradiation on Wound Healing in a Rat Cutaneous Full-Thickness Wound Model

2018 ◽  
Author(s):  
Jian-Xin Yan ◽  
Xuan Liao ◽  
Sheng-Hong Li ◽  
Hong-Wei Liu ◽  
Han-Yu Chang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Full Thickness ◽  
Wound Model ◽  
Carbon Arc ◽  
Full Thickness Wound

scholarly journals PLA Nanofibrous Scaffolds for Full Thickness Wound Healing

2018 ◽  
Vol 28 (1) ◽  
pp. 069-073
Author(s):  
Maksym V. Pogorielov ◽  
◽  
Volodymyr N. Deineka ◽  
R. G. Vasyliev ◽  
D. A. Zubov ◽  
...  
Keyword(s):  
Wound Healing ◽  
Full Thickness ◽  
Nanofibrous Scaffolds ◽  
Full Thickness Wound
Sign in / Sign up

Export Citation Format

Share Document