Evaluation of additive effect of quantitative fetal fibronectin to cervical length for prediction of spontaneous preterm birth among asymptomatic low-risk women

2016 ◽  
Vol 95 (8) ◽  
pp. 948-955 ◽  
Author(s):  
Sushma Jwala ◽  
Tino L. Tran ◽  
Courtney Terenna ◽  
Ali McGregor ◽  
Jocelyn Andrel ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Cervical Length ◽  
Low Risk ◽  
Additive Effect ◽  
Spontaneous Preterm Birth ◽  
Fetal Fibronectin ◽  
Low Risk Women

scholarly journals A Combination of Cervicovaginal Fluid Glutamate, Acetate and D-Lactate Identified Asymptomatic Low-Risk Women Destined to Deliver Preterm: a Prospective Cohort Study

2021 ◽  
Author(s):  
Emmanuel Amabebe ◽  
Dilly O. C. Anumba
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Characteristic Curve ◽  
Cervical Length ◽  
Low Risk ◽  
Prior History ◽  
Study Cohort ◽  
Fetal Fibronectin ◽  
Low Risk Women ◽  
Cervicovaginal Fluid

AbstractDue to the modest predictive capacities and limited clinical application of transvaginal ultrasonographic cervical length (CL) and quantitative fetal fibronectin (qfFN) in pregnant women at low risk of preterm birth (PTB), we sought to determine the utility of cervicovaginal fluid (CVF) metabolites (by-products of host-microbial metabolism) for prediction of spontaneous PTB in asymptomatic low-risk women at mid-gestation. This was a prospective sub-cohort study from the ECCLIPPx study cohort. CVF from asymptomatic singleton women (20–22 weeks, n = 168) without a prior history of PTB were analysed for metabolites by enzyme-based spectrophotometry. CL, vaginal pH and qfFN were also measured. Correlation and predictive analyses were performed by Spearman’s correlation, and binary logistic regression and area under receiver operating characteristic curve (AUC), respectively. Of the 168 women enrolled, only CVF samples from 135 (80.4%) women were analysed. There were 6/135 (4.4%) spontaneous PTB (sPTBs), with two of these pregnancies ending ≤ 28 weeks’ gestation. Individually (AUC, 95% CI), only glutamate (0.72, 0.64–0.80) and CL (0.69, 0.60–0.77) were predictive of PTB. However, five multivariable models that more accurately predicted sPTB were also identified, i.e. a combination of: glutamate, acetate and D-lactate (GAD, 0.82, 0.74–0.89); CL and qfFN only (0.78, 0.70–0.85); CL, qfFN, glutamate and acetate (0.88, 0.81–0.93); CL, qfFN and GAD (0.94, 0.88–0.98); and GAD and pH (0.86, 0.79–0.92). Correlations between CL, pH and qfFN and metabolites were also observed. In this cohort, a midtrimester combination of CVF glutamate, acetate and D-lactate predicted preterm birth more accurately than individual metabolites, cervical length and fetal fibronectin with a very low false-positive rate and high positive predictive value. Further testing in populations with higher preterm birth rates is required.

The Preterm Prediction Study: Can low-risk women destined for spontaneous preterm birth be identified?

2001 ◽  
Vol 184 (4) ◽  
pp. 652-655 ◽  
Author(s):  
J.D. Iams ◽  
R.L. Goldenberg ◽  
B.M. Mercer ◽  
A.H. Moawad ◽  
P.J. Meis ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Low Risk ◽  
Spontaneous Preterm Birth ◽  
Low Risk Women

Prediction of spontaneous preterm birth in asymptomatic twin pregnancies with the use of combined fetal fibronectin and cervical length

2009 ◽  
Vol 201 (3) ◽  
pp. 313.e1-313.e5 ◽  
Author(s):  
Nathan S. Fox ◽  
Daniel H. Saltzman ◽  
Chad K. Klauser ◽  
Danielle Peress ◽  
Christina V. Gutierrez ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Cervical Length ◽  
Spontaneous Preterm Birth ◽  
Fetal Fibronectin ◽  
Twin Pregnancies
Sign in / Sign up

Export Citation Format

Share Document