scholarly journals Prenatal administration of vaginal progesterone and frequency of uterine contractions in asymptomatic twin pregnancies

2016 ◽  
Vol 95 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Lília A.M.L de Oliveira ◽  
Maria L. Brizot ◽  
Adolfo W. Liao ◽  
Roberto E. Bittar ◽  
Rossana P.V. Francisco ◽  
...  
Keyword(s):  
Uterine Contractions ◽  
Vaginal Progesterone ◽  
Twin Pregnancies

scholarly journals Successfully delayed delivery of second twin after early second trimester rupture of membranes of the first twin: a case report

2020 ◽  
Vol 12 (2) ◽  
pp. 81-85
Author(s):  
Jadranka Georgievska ◽  
Igor Samardziski ◽  
Ana Daneva ◽  
Goran Kocoski
Keyword(s):  
Preterm Delivery ◽  
Good Condition ◽  
Fetal Lung ◽  
Intrauterine Death ◽  
Lung Maturation ◽  
Uterine Contractions ◽  
Regular Control ◽  
Level Institution ◽  
Twin Pregnancies ◽  
Second Twin

Twin pregnancies are high-risk pregnancies accompanied with multiple complications, such as: spontaneous abortion, preterm rupture of the membranes, preterm delivery, intrauterine death of one or both twins etc. There is no consensus about the management of twin  pregnancies complicated with preterm rupture of the membranes of one twin and risk of preterm delivery. These cases are rarely found in the literature. We present a case of a 35 years old patient, hospitalized in a tertiary level institution, because of a diamniotic dichorionic twin pregnancy complicated with preterm rupture of the membranes of the first twin at 19 weeks of gestation. She had one delivery with Caesarean section 16 years ago. In consultation with the patient induction of labor was done with delivery of the first twin, a death male fetus. After that, antibiotics and tocolytic therapy were administrated and the patient remained in the hospital about one week. The patient was discharged at home with regular control of her condition and condition of the fetus. The patient was again hospitalized at 33 weeks of gestation with uterine contractions on cardiotocography. After administration of corticosteroid therapy for fetal lung maturation she delivered spontaneously the second twin in a good condition and  she was discharged from hospital after 16 days. In twin pregnancies clinicians must think about delayed interval delivery of the second twin, after delivery of the first twin, with an aim to increase chances for survival, especially for pregnancies less than 30 weeks of gestation.

scholarly journals 552: Twin pregnancies with short cervix: Vaginal progesterone is agent of choice for preterm delivery prevention

2019 ◽  
Vol 220 (1) ◽  
pp. S368-S369 ◽  
Author(s):  
Jared T. Roeckner ◽  
Melanie Mitta ◽  
Luis Sanchez-Ramos ◽  
Andrew M. Kaunitz
Keyword(s):  
Preterm Delivery ◽  
Short Cervix ◽  
Vaginal Progesterone ◽  
Twin Pregnancies

scholarly journals Study of progesterone for the prevention of preterm birth in twins (STOPPIT): Findings from a trial-based cost-effectiveness analysis

2010 ◽  
Vol 26 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Oya Eddama ◽  
Stavros Petrou ◽  
Dean Regier ◽  
John Norrie ◽  
Graeme MacLennan ◽  
...  
Keyword(s):  
Economic Evaluation ◽  
Preterm Birth ◽  
Cost Effectiveness ◽  
Controlled Trial ◽  
Bootstrap Method ◽  
Cost Difference ◽  
Nonparametric Bootstrap ◽  
Vaginal Progesterone ◽  
Maternity Hospitals ◽  
Twin Pregnancies

Objectives: Preterm birth contributes to a range of healthcare problems amongst infants surmounting to sizeable healthcare costs. Twin pregnancies are at particular risk of preterm birth. The objective of this study was to assess the cost-effectiveness of vaginal progesterone gel for the prevention of preterm birth in twin pregnancies.Methods: An economic evaluation was conducted alongside a randomized placebo controlled trial (the STOPPIT trial) of vaginal progesterone gel for the prevention of preterm birth in twin pregnancies. Five hundred women were recruited from nine maternity hospitals in the United Kingdom. The outcomes of the economic evaluation were presented in terms of net benefit statistics, cost-effectiveness acceptability curves, generated using the nonparametric bootstrap method, and the expected value of perfect information.Results: Mean health service costs between the period of randomization and discharge for mother and infant were £28,031 in the progesterone group and £25,972 in the placebo group, generating a mean nonsignificant cost difference of £2,059 (bootstrap mean cost difference £2,334; 95 percent confidence interval: −£5,023, £9,142; p = .33). The probability of progesterone being cost-effective was 20 percent at a willingness to pay threshold of £30,000 per preterm birth prevented. There is little economic justification for conducting further research into the use of vaginal progesterone gel in twin pregnancies for the prevention of preterm birth.Conclusions: Further studies of preventive interventions for preterm birth more generally are required given the scale of the clinical and economic burden of this condition. These studies should be sufficiently powered for economic endpoints and extend beyond hospital discharge.

scholarly journals Vaginal Progesterone Has No Diabetogenic Potential in Twin Pregnancies: A Retrospective Case-Control Study on 1686 Pregnancies

2020 ◽  
Vol 9 (7) ◽  
pp. 2249
Author(s):  
Klara Rosta ◽  
Katharina Al-Bibawy ◽  
Maria Al-Bibawy ◽  
Wilhelm Temsch ◽  
Stephanie Springer ◽  
...  
Keyword(s):  
Binary Logistic Regression ◽  
Control Group ◽  
Retrospective Case ◽  
Smoking During Pregnancy ◽  
Exact Test ◽  
Vaginal Progesterone ◽  
Increased Risk ◽  
Chi Squared ◽  
Student’S T ◽  
Twin Pregnancies

Background: In this study, we aimed to investigate the incidence of gestational diabetes mellitus (GDM) in women who carried twin pregnancies and received vaginal progesterone. Methods: In this retrospective cohort study, 203 out of 1686 women with twin pregnancies received natural progesterone (200 mg/day between gestational weeks 16 + 0 and 36 + 0) vaginally for ≥ 4 weeks. The control group consisted of 1483 women with twin pregnancies without progesterone administration. Pearson’s Chi squared test, Fisher’s exact test, and Student’s t-test was used to compare differences between the control and the progesterone-treated groups. A multivariate binary logistic regression was performed to assess relative independent associations on the dependent outcome of GDM incidence. Results: Vaginal progesterone treatment in twin pregnancies had no significant influence on developing GDM (p = 0.662). Higher pre-pregnancy BMI (OR 1.1; p < 0.001), GDM in previous pregnancy (OR 6.0; p < 0.001), and smoking during pregnancy (OR 1.6; p = 0.014) posed an increased risk for developing GDM. Conclusion: In twin pregnancies, the use of vaginal progesterone for the prevention of recurrent preterm delivery was not associated with an increased risk of GDM.

Management of Twin Labor

1972 ◽  
Vol 22 (S1) ◽  
pp. 70-72
Author(s):  
Z. Sternadel ◽  
A. Lysikiewicz
Keyword(s):  
Maternal Mortality ◽  
Perinatal Mortality ◽  
Apgar Score ◽  
Optimum Time ◽  
Neonatal Deaths ◽  
Uterine Contractions ◽  
The Mean ◽  
Twin Pregnancies ◽  
Second Twin ◽  
Stimulation Of

Investigations were carried out on 68 labors in twin pregnancies. It was observed that, upon stimulation of uterine contractions by means of oxytocic agents, mainly oxytocin (90%), the mean duration of labor was significantly reduced to about 7 hours, and prolonged labors (over 20 hours) were completely eliminated. The time between delivery of the first and the second baby is now below 30 minutes in all cases, and this is regarded as the optimum time. No neonatal deaths were observed in labors taking place at term. The condition of the newborns at birth was estimated in accordance with the Apgar score and it was found that the second newborn scored worse than the first one; a fact definitely related to the higher proportion of operative procedures during delivery of the second twin (48%) as compared to the first one (10%).The authors stress that, owing to the introduction of the method of conducting twin labors, maternal mortality has been completely eliminated and twin perinatal mortality has been markedly reduced: from about 28% in 1923-1962 to about 10% in recent years.

Sign in / Sign up

Export Citation Format

Share Document