Prevalence of human papillomavirus in epithelial ovarian cancer tissue. A meta-analysis of observational studies

2013 ◽  
Vol 93 (1) ◽  
pp. 6-19 ◽  
Author(s):  
Malene F. Svahn ◽  
Mette T. Faber ◽  
Jane Christensen ◽  
Bodil Norrild ◽  
Susanne K. Kjaer
Keyword(s):  
Ovarian Cancer ◽  
Human Papillomavirus ◽  
Epithelial Ovarian Cancer ◽  
Observational Studies ◽  
Meta Analysis ◽  
Cancer Tissue ◽  
Ovarian Cancer Tissue

scholarly journals Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis

2015 ◽  
pp. 3523 ◽  
Author(s):  
Zengjun Li ◽  
Haipeng Wang ◽  
Yanlai Sun ◽  
Zhongfa Xu ◽  
Jianjun Han ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Meta Analysis ◽  
High Mobility ◽  
High Mobility Group ◽  
Cancer Tissue ◽  
Ovarian Cancer Tissue

Association of expression of p53, livin, ERCC1, BRCA1 and PARP1 in epithelial ovarian cancer tissue with drug resistance and prognosis

2020 ◽  
Vol 216 (2) ◽  
pp. 152794 ◽  
Author(s):  
Zhengmao Zhang ◽  
Xiaomeng Dou ◽  
Hongfang Yang ◽  
Ling Jia ◽  
Kaiyun Qin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Resistance ◽  
Epithelial Ovarian Cancer ◽  
Cancer Tissue ◽  
Ovarian Cancer Tissue

scholarly journals Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer

2021 ◽  
Vol 22 (16) ◽  
pp. 8479
Author(s):  
Tilman L. R. Vogelsang ◽  
Aurelia Vattai ◽  
Elisa Schmoeckel ◽  
Till Kaltofen ◽  
Anca Chelariu-Raicu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Epithelial Ovarian Cancer ◽  
Tnm Classification ◽  
Rank Correlation ◽  
University Hospital ◽  
Cancer Tissue ◽  
Low Grade ◽  
High Grade ◽  
Trace Amine

Trace amine-associated receptor 1 (TAAR1) is a Gαs- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T1AM) reduces cell viability and induces cell death and DNA damage. Aim of this study was to evaluate the prognostic value of TAAR1 on overall survival of ovarian carcinoma patients and the correlation of TAAR1 expression with clinical parameters. Ovarian cancer tissue of n = 156 patients who were diagnosed with epithelial ovarian cancer (serous, n = 110 (high-grade, n = 80; low-grade, n = 24; unknown, n = 6); clear cell, n = 12; endometrioid, n = 21; mucinous, n = 13), and who underwent surgery at the Department of Obstetrics and Gynecology, University Hospital of the Ludwig-Maximilians University Munich, Germany between 1990 and 2002, were analyzed. The tissue was stained immunohistochemically with anti-TAAR1 and evaluated with the semiquantitative immunoreactive score (IRS). TAAR1 expression was correlated with grading, FIGO and TNM-classification, and analyzed via the Spearman’s rank correlation coefficient. Further statistical analysis was obtained using nonparametric Kruskal-Wallis rank-sum test and Mann-Whitney-U-test. This study shows that high TAAR1 expression is a positive prognosticator for overall survival in ovarian cancer patients and is significantly enhanced in low-grade serous carcinomas compared to high-grade serous carcinomas. The influence of TAAR1 as a positive prognosticator on overall survival indicates a potential prognostic relevance of signal transduction of thyroid hormone derivatives in epithelial ovarian cancer. Further studies are required to evaluate TAAR1 and its role in the development of ovarian cancer.

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