Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss)

2015 ◽  
Vol 22 (3) ◽  
pp. 586-596 ◽  
Author(s):  
B. Pfundt ◽  
B. Mielenz ◽  
F. Sanver ◽  
E. Pfeffer ◽  
H. Sauerwein ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Rainbow Trout ◽  
Growth Factor ◽  
Oncorhynchus Mykiss ◽  
Enzyme Immunoassay ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Rainbow Trout Oncorhynchus Mykiss

Insulin-like growth factor and growth hormone receptor in nephrotic rats

1994 ◽  
Vol 266 (1) ◽  
pp. E102-E106
Author(s):  
M. A. Thabet ◽  
A. Challa ◽  
W. Chan ◽  
F. Liu ◽  
R. L. Hintz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Nephrotic Syndrome ◽  
Growth Factor ◽  
Growth Retardation ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Serum Insulin ◽  
Control Group ◽  
Insulin Like Growth Factor ◽  
Igf I

In an attempt to elucidate the mechanism of growth retardation in the nephrotic syndrome, specific serum and hepatic growth factors were measured in Sprague-Dawley rats in which nephrotic syndrome was produced by administration of puromycin (1.5 mg.100 g body wt-1.day-1) for 12 days. On the 13th day, the results of these nephrotic animals were compared with those of an equal number of pair-fed and control animals: the mean dietary intake of the nephrotic group was 71% that of the control group (P < 0.001). Serum insulin-like growth factor (IGF) binding protein-3 was significantly reduced (P < 0.005) in the nephrotic rats, compared with the pair-fed and the control groups. Hepatic IGF-I mRNA in the nephrotic rats averaged 36% that of control (P < 0.001) and 46% that of the pair-fed animals (P < 0.001). Hepatic growth hormone receptor (GHr) mRNA in the nephrotic rats averaged 19% of that of the control (P < 0.001) and 27% of that of the pair-fed rats (P < 0.001). These results indicate that the growth retardation of the nephrotic rats may be associated with the significant decrease in IGF-I mRNA and reduction in GHr mRNA.

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