The hepatoprotective effect from ischemia‐reperfusion injury of remote ischemic preconditioning in the liver related surgery: a meta‐analysis

2021 ◽  
Author(s):  
Jinli Wu ◽  
Chao Yu ◽  
Xianggang Zeng ◽  
Chengyi Sun
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Hepatoprotective Effect ◽  
Remote Ischemic Preconditioning

scholarly journals Role of Remote Ischemic Preconditioning in Hepatic Ischemic Reperfusion Injury

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582094692
Author(s):  
Eun Kyung Choi ◽  
Hoon Jung ◽  
Sungmin Jeon ◽  
Jung A. Lim ◽  
Jungwon Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Inflammatory Cytokines ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Remote Ischemic Preconditioning ◽  
Hepatic Tissue ◽  
Hepatic Ischemia

The effect of remote ischemic preconditioning (RIPC) has been proposed that mediates the protective response in ischemia reperfusion injury (IRI) of various organs. In this study, we investigated the effect of RIPC in hepatic IRI, by assessing biomarker of oxidative stress and inflammatory cytokines. Moreover, we intended to demonstrate any such protective effect through nitric oxide (NO). Twenty-five rats were divided into the 5 groups: (1) Sham; (2) RIPC; (3) hepatic IRI; (4) RIPC + hepatic IRI; (5) C-PTIO, 2-(4-carboxyphenyl)-4,5dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3oxide, + RIPC + hepatic IRI. RIPC downregulated the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), histologic damage, and activity of Malondialdehyde (MDA). However, there was no significant reduction in the level of tumor necrosis factor-alpha (TNF-α) and nuclear factor kappa B (NF-κB). AST and ALT levels, and hepatic tissue morphology in the C-PTIO group showed a significant improvement compared to those of the RIPC + hepatic IRI group. The application of RIPC before hepatic ischemia downregulated the oxidative stress, not the inflammatory cytokines. Moreover, these protective effect of RIPC would be mediated through the activation of NO as well as anti-oxidant effect.

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