Complete pathological response after ceritinib for anaplastic lymphoma kinase‐rearranged epithelioid peritoneal mesothelioma

2021 ◽  
Vol 91 (3) ◽  
pp. 475-476
Author(s):  
Shinichiro Sakata ◽  
Helen Rees ◽  
Simon Parke ◽  
Norman J. Carr ◽  
Danko Kostadinov ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Pathological Response ◽  
Peritoneal Mesothelioma ◽  
Complete Pathological Response ◽  
Anaplastic Lymphoma

Detection of Anaplastic Lymphoma Kinase-Rearranged Mesothelioma Cells in Ascites by Companion Diagnostics

2019 ◽  
Vol 64 (4) ◽  
pp. 378-385
Author(s):  
Maho Konishi ◽  
Takahiro Kanyama ◽  
Kenichiro Maeno ◽  
Chiho Miyagawa ◽  
Sachiko Minamiguchi ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Abdominal Mass ◽  
Peritoneal Mesothelioma ◽  
Serous Carcinoma ◽  
Cancer Center ◽  
Tumor Type ◽  
Companion Diagnostics ◽  
Anaplastic Lymphoma ◽  
Tumor Dissemination ◽  
Tissue Specimens

Background: A case of peritoneal mesothelioma with an anaplastic lymphoma kinase (ALK) translocation was identified, and we conducted further studies to obtain diagnostic and therapeutic insights. We believe that this is the first report describing the cytology of this new tumor type. Case: A teenage woman was referred for severe pleural effusion. Enhanced computed tomography indicated an abdominal mass with ascites. Laparoscopy revealed tumor dissemination from the pelvis to the upper abdomen. Because a high-grade serous carcinoma was suspected, ascitic cytology and biopsy were performed. Cytologically, the tumor displayed characteristics of both adenocarcinoma and reactive or neoplastic mesothelial cells. After extensive pathological evaluation, the tumor was diagnosed as malignant peritoneal mesothelioma. To verify the diagnosis and aid in developing a therapeutic strategy, several companion diagnostics were tried. Surprisingly, the tumor was ALK-positive, and ALK recombination was confirmed by an ALK break-apart test. Retrospectively, cells and tissue specimens were stained with ALK intercalated antibody-enhanced polymer. Tumor cells were clearly distinguished from the nonneoplastic background. Recombination in ALK was reconfirmed by the National Cancer Center Japan, and the patient was enrolled in a clinical trial for alectinib. Conclusion: Companion diagnostics-based cytology may provide a useful means of monitoring and evaluating a molecular-targeted therapy.

Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel ALK-related tumour spectrum

2015 ◽  
Vol 68 (4) ◽  
pp. 603-607 ◽  
Author(s):  
Kongsak Loharamtaweethong ◽  
Napaporn Puripat ◽  
Nadda Aoonjai ◽  
Apisada Sutepvarnon ◽  
Chanyoot Bandidwattanawong
Keyword(s):  
Case Report ◽  
Anaplastic Lymphoma Kinase ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Anaplastic Lymphoma ◽  
Tumour Spectrum

Anaplastic Lymphoma Kinase in Human Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Christina Schonherr ◽  
Bengt Hallberg ◽  
Ruth Palmer
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Human Cancer ◽  
Anaplastic Lymphoma
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