Defining an optimal surgical strategy for synchronous colorectal liver metastases: staged versus simultaneous resection?

2014 ◽  
Vol 85 (11) ◽  
pp. 829-833 ◽  
Author(s):  
Wong Hoi She ◽  
Albert Chi Yan Chan ◽  
Ronnie Tung Ping Poon ◽  
Tan To Cheung ◽  
Kenneth Siu Ho Chok ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Surgical Strategy ◽  
Simultaneous Resection ◽  
Synchronous Colorectal Liver Metastases

scholarly journals Comparison of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2020 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Tumour ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases

Abstract Background: The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P =0.166). The overall survival at 1 and 3 years in the SeR group (93.9% and 50.1%) was lower than that in the DeR group (94.9% and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0% and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4% and 18.4%) was lower than that in the DeR group (43.9% and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4% and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases >30 mm and SiR (compared with DeR) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.

scholarly journals Comparison of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2020 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Tumour ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases

Abstract Background: The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P =0.166). The overall survival at 1 and 3 years in the SeR group (93.9% and 50.1%) was lower than that in the DeR group (94.9% and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0% and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4% and 18.4%) was lower than that in the DeR group (43.9% and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4% and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases >30 mm and SiR (compared with DeR) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.

scholarly journals Compare of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2019 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases ◽  
Perioperative Safety

Abstract Background: The present study aimed to compare perioperative safety and long-term survival of patients with synchronous colorectal liver metastases receiving sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data of patients receiving surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, p=0.007) and the SeR group (16.3%, p=0.166). Overall survival at 1-year and 3-year in the SeR group (93.9% and 50.1%) was lower than the DeR group (94.9% and 64.8%, p=0.019), but not statistically different compared with the SiR group (93.0% and 55.2%, p=0.378). Recurrence-free survival at 1-year and 3-year in the SeR group (22.4% and 18.4%) was lower than the DeR group (43.9% and 24.2%, p=0.033), but not statistically different compared with the SiR group (31.4% and 19.6%, p=0.275). Cox multivariate analysis indicated that T4, lymph node positive primary tumor, liver metastases>30mm and selective sequential resection (compared with delayed resection) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complication, and when staged resection strategy was made, the prognosis of delayed resection was better than that of sequential resection.

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