Effects of transdermal nicotine delivery on cognitive outcomes: A meta‐analysis

Author(s):  
Alireza Majdi ◽  
Saeed Sadigh‐Eteghad ◽  
Albert Gjedde
2021 ◽  
Vol 53 (1) ◽  
pp. 971-997
Author(s):  
Danielle Cahoon ◽  
Shruti P. Shertukde ◽  
Esther E. Avendano ◽  
Jirayu Tanprasertsuk ◽  
Tammy M. Scott ◽  
...  

2016 ◽  
Vol 52 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Lívia Neves Borgheti-Cardoso ◽  
Fabiana Testa Moura de Carvalho Vicentini ◽  
Tais Gratieri ◽  
Maria Vitória Lopes Badra Bentley

ABSTRACT Transdermal nicotine patches have been used in smoking cessation therapy, suggested for the treatment of skin disorders with eosinophilic infiltration and have been found to improve attention performance in patients with Alzheimer's disease and age-associated memory impairment. However, skin irritation with extended patch use is still a problem. The aim of this work was to develop a simple to prepare liquid crystalline system containing vitamin E TPGS that would be able to control nicotine delivery and reduce irritation and sensitization problems. The liquid crystalline phases were macroscopically characterized by visual analysis and examined microscopically under a polarized light microscope. Topical and transdermal delivery of nicotine were investigated in vitro using porcine ear skin mounted on a Franz diffusion cell. Nicotine skin permeation from the developed cubic phase followed zero-order kinetics (r = 0.993) and was significantly enhanced after 12 h when compared to the control formulation (nicotine solution) (p < 0.05) (138.86 ± 20.44 and 64.91 ± 4.06 μg/cm2, respectively). Cubic phase was also able to target viable skin layers in comparison to control solution (8.18 ± 1.89 and 2.63 ± 2.51 μg/cm2, respectively). Further studies to evaluate skin sensitization and irritation are now necessary.


1997 ◽  
Vol 148 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Derek Lewis ◽  
Mário Paulo ◽  
Eduardo Faustino ◽  
Asçensão Farinha

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S777-S778
Author(s):  
Antonio Terracciano ◽  
Angelina R Sutin

Abstract Personality traits are associated with cognitive outcomes across the lifespan, including cognitive function in young adulthood and risk of cognitive impairment and dementia in old age. This study examined the association between the Five Factor Model personality traits and verbal fluency in 10 cohorts (11 samples) that totaled more than 90,000 participants (age range 16-101). Meta-analysis indicated that participants who scored lower in Neuroticism, and higher in Extraversion, Openness, and Conscientiousness retrieved more words, independent of age, gender, and education. These associations were consistent across semantic and letter fluency tasks. Moderation analysis indicated that the associations between personality and semantic fluency were stronger in older samples (except for Openness) and among individuals with lower education. This pattern suggests that these associations are stronger in groups vulnerable to cognitive impairment and dementia. Personality traits have pervasive associations with fluency tasks that are replicable across samples and age groups.


2018 ◽  
Vol 66 (12) ◽  
pp. 2327-2334 ◽  
Author(s):  
Mark A. Oldham ◽  
Jacqueline Vachon ◽  
David Yuh ◽  
Hochang B. Lee

2020 ◽  
Vol 118 ◽  
pp. 472-484
Author(s):  
Wolfgang Marx ◽  
Andrew Scholey ◽  
Joseph Firth ◽  
Nathan M. D’Cunha ◽  
Melissa Lane ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document