Neurological symptoms and blood neurofilament light levels

2021 ◽  
Author(s):  
Christian Barro ◽  
Henrik Zetterberg
Keyword(s):  
Neurological Symptoms ◽  
Neurofilament Light ◽  
Light Levels

scholarly journals CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

2017 ◽  
Vol 49 ◽  
pp. 138-144 ◽  
Author(s):  
Ane-Victoria Idland ◽  
Roser Sala-Llonch ◽  
Tom Borza ◽  
Leiv Otto Watne ◽  
Torgeir Bruun Wyller ◽  
...  
Keyword(s):  
Older Adults ◽  
Hippocampal Atrophy ◽  
Neurofilament Light ◽  
Healthy Older Adults ◽  
Light Levels

scholarly journals Serum neurofilament light levels in normal aging and their association with morphologic brain changes

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael Khalil ◽  
Lukas Pirpamer ◽  
Edith Hofer ◽  
Margarete M. Voortman ◽  
Christian Barro ◽  
...  
Keyword(s):  
Normal Aging ◽  
Neurofilament Light ◽  
Light Levels ◽  
Brain Changes

scholarly journals High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms

2020 ◽  
Author(s):  
Christiana Franke ◽  
Caroline Ferse ◽  
Jakob Kreye ◽  
S Momsen Reincke ◽  
Elisa Sanchez-Sendin ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
High Frequency ◽  
Clinical Symptoms ◽  
Epileptic Seizures ◽  
Neurological Symptoms ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Intensive Care Patients ◽  
Neuronal Autoantibodies ◽  
The Brain

AbstractCOVID-19 intensive care patients occasionally develop neurological symptoms. The absence of SARS-CoV-2 in most cerebrospinal fluid (CSF) samples suggests the involvement of further mechanisms including autoimmunity. We therefore determined whether anti-neuronal or anti-glial autoantibodies are present in eleven consecutive severely ill COVID-19 patients presenting with unexplained neurological symptoms. These included myoclonus, cranial nerve involvement, oculomotor disturbance, delirium, dystonia and epileptic seizures. Most patients showed signs of CSF inflammation and increased levels of neurofilament light chain. All patients had anti-neuronal autoantibodies in serum or CSF when assessing a large panel of autoantibodies against intracellular and surface antigens relevant for central nervous system diseases using cell-based assays and indirect immunofluorescence on murine brain sections. Antigens included proteins well-established in clinical routine, such as Yo or NMDA receptor, but also a variety of specific undetermined epitopes on brain sections. These included vessel endothelium, astrocytic proteins and neuropil of basal ganglia, hippocampus or olfactory bulb. The high frequency of autoantibodies targeting the brain in the absence of other explanations suggests a causal relationship to clinical symptoms, in particular to hyperexcitability (myoclonus, seizures). While several underlying autoantigens still await identification in future studies, presence of autoantibodies may explain some aspects of multi-organ disease in COVID-19 and can guide immunotherapy in selected cases.

ELEVATED CEREBROSPINAL FLUID NEUROFILAMENT LIGHT LEVELS ARE ASSOCIATED WITH COMPROMISED WHITE MATTER INTEGRITY AMONG OLDER ADULTS

2017 ◽  
Vol 13 (7) ◽  
pp. P207
Author(s):  
Elizabeth E. Moore ◽  
Timothy J. Hohman ◽  
Faizan Badami ◽  
Kimberly R. Pechman ◽  
Elizabeth A. Gordon ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
White Matter Integrity ◽  
Neurofilament Light ◽  
Light Levels

scholarly journals Association of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode

2020 ◽  
Vol 3 (11) ◽  
pp. e2016278
Author(s):  
Tatiana Plavina ◽  
Carol M. Singh ◽  
Dipen Sangurdekar ◽  
Carl de Moor ◽  
Bob Engle ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Neurofilament Light ◽  
Light Levels

P1-116: NEUROFILAMENT LIGHT LEVELS IN THE CEREBROSPINAL FLUID ARE UNCOUPLED OF AMYLOIDOSIS IN LATE STAGE PATHOGENESIS OF APP TRANSGENIC MICE

2006 ◽  
Vol 14 (7S_Part_5) ◽  
pp. P315-P315
Author(s):  
Ruth E. Droege ◽  
Stephan A. Kaeser ◽  
Juliane Schelle ◽  
Lisa M. Haesler ◽  
Rawaa Al-Shaana ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Late Stage ◽  
Neurofilament Light ◽  
Light Levels
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