Clinical correlations of striatal hand deformities in Parkinson's disease

2019 ◽  
Vol 140 (2) ◽  
pp. 162-166
Author(s):  
José Fidel Baizabal‐Carvallo ◽  
Marlene Alonso‐Juarez ◽  
Blanca Murillo Ortiz ◽  
Robert Fekete
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Hand Deformities ◽  
Clinical Correlations ◽  
Striatal Hand

scholarly journals “Striatal Hand Signs” and early diagnosis of Parkinson’s Disease: The “Monkey-Wrench Sign”

2021 ◽  
Author(s):  
Igor de Lima e Teixeira ◽  
Vanessa Pereira de Alencar Souza ◽  
Caroline Zorzenon ◽  
Beatriz Azevedo dos Anjos Godke Veiga ◽  
Vanderci Borges ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Onset ◽  
Ulnar Deviation ◽  
Advanced Parkinson’S Disease ◽  
Metacarpophalangeal Joints ◽  
Affected Side ◽  
Hand Deformities ◽  
Distal Interphalangeal ◽  
Striatal Hand

Background: Striatal hand signs, first described by Charcot, are reported in 10% of advanced Parkinson’s Disease patients as flexion of the metacarpophalangeal joints, extension of proximal interphalangeal joints, flexion of distal interphalangeal joints and ulnar deviation. Another deformation is the metacarpophalangeal joints flexion and thumb medialization (U shaped - “Monkey-Wrench sign”). We believe that mild hand deformities are present in earlier phases of the disease and may help the diagnosis of PD. Objectives: To identify hand deformities in PD patient. Methods: We evaluated 36 PD patients, according to UKPDS Brain Bank Diagnostic Criteria, side of onset, disease duration, severity by UPDRS part III - left/ right side, hand deformities and the “monkey-wrench sign”. Results: We had 14 patients 10 years. 2/3 had left side onset. 33 patients (91.67%) presented the “Monkey- Wrench sign”, unilaterally or asymmetrically, and it was present in all PD patients > 4 years of disease onset, but it was present only in 78.6% less than 4 years. The “MW” sign was easily detected in the more affected side, with a mean UPDRS score of 31.1 on the side of striatal hand signs compared to the mean score of 24.7 on the less affected side. Conclusions: Striatal hand deformities and the “Monkey-Wrench” sign may be useful to diagnosis PD, if unilateral or asymmetrical signs, as well as, it could be used to differentiate between tremors of PD and other etiologies, in a more visual way.

Effect of Subthalamic Nucleus Stimulation on Severe Striatal Hand Deformity in Parkinson's Disease: A Case Report

2008 ◽  
Vol 11 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Takashi Morishita ◽  
Yoichi Katayama ◽  
Kazutaka Kobayashi ◽  
Hideki Oshima ◽  
Chikashi Fukaya ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Report ◽  
Subthalamic Nucleus ◽  
Subthalamic Nucleus Stimulation ◽  
Hand Deformity ◽  
Striatal Hand

The frequency and diagnostic accuracy of hand deformities in Parkinson’s disease

2018 ◽  
Vol 125 (12) ◽  
pp. 1813-1817 ◽  
Author(s):  
José Fidel Baizabal-Carvallo ◽  
Marlene Alonso-Juarez ◽  
Robert Fekete
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Diagnostic Accuracy ◽  
Hand Deformities

Striatal hand in a woman with Parkinson's disease

2018 ◽  
Vol 79 (2) ◽  
pp. 109-109
Author(s):  
Tian Meng ◽  
Damian Bruce-Hickman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Striatal Hand

Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase (COMT) inhibitors or B vitamins? Results from a review

2007 ◽  
Vol 45 (12) ◽  
Author(s):  
Stefano Zoccolella ◽  
Giovanni Iliceto ◽  
Michele deMari ◽  
Paolo Livrea ◽  
Paolo Lamberti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Plasma Homocysteine ◽  
B Vitamins ◽  
Elevated Plasma ◽  
Therapeutic Approaches ◽  
Cytotoxic Effects ◽  
Comt Inhibitors ◽  
Clinical Correlations ◽  
Diet Supplementation

AbstractIn recent years, L-Dopa treatment has been indicated as an acquired cause of hyperhomocysteinemia (HHcy). The mechanism underlying L-Dopa-related HHcy is the O-methylation of the drug catalyzed by the enzyme catechol-O-methyltransferase (COMT). Folate and cobalamin status also influences the effects of L-Dopa on plasma homocysteine (Hcy) levels. Although clinical correlations of HHcy in Parkinson's disease still remain uncertain, management of elevated plasma Hcy levels has been advocated, due to multiple cytotoxic effects of Hcy on neurons. This review summarizes data available in the literature concerning the two main therapeutic approaches to L-Dopa-related HHcy (use of COMT inhibitors or B vitamins diet supplementation).Clin Chem Lab Med 2007;45:1607–13.

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