scholarly journals Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance

2018 ◽  
Vol 139 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Frank J. E. Vajda ◽  
Terence J. O'Brien ◽  
Janet E. Graham ◽  
Alison A. Hitchcock ◽  
Cecilie M. Lander ◽  
...  
Keyword(s):  
Foetal Malformations

scholarly journals 007 The outcome of a cohort of pregnancies in australian women with epilepsy

2019 ◽  
Vol 90 (e7) ◽  
pp. A3.1-A3
Author(s):  
Frank JE Vajda ◽  
Janet E Graham ◽  
Alison A Hitchcock ◽  
Cecilie M Lander ◽  
Terry J O’Brien ◽  
...  
Keyword(s):  
Retention Rate ◽  
Foetal Death ◽  
Telephone Interviews ◽  
Born Infant ◽  
Induced Abortions ◽  
Ethical Approval ◽  
Loss Of Contact ◽  
Major Illness ◽  
Foetal Malformations

BackgroundThe Australian Pregnancy Register (APR) established in 1998, collects data concerning the hazard of foetal malformations from intrauterine exposure to antiepileptic drugs.Methods4 telephone interviews, ethical approval, informed consent, observational study, statistical analyses.ResultsBy December 2017, the APR recorded 1879 pregnancies, followed prospectively. There had been 1766 live births (94.0%), 5 stillbirths (0.3%), 54 spontaneous abortions (2.9%), and 30 induced abortions (1.6%), while 24 pregnancies had an unknown outcome due to loss of contact with the women involved (1.3%). Foetal malformations had occurred in 71 of the live-born infants. Of the induced abortions, 15 had been for intrauterine foetal death, 10 for major foetal malformation (spina bifida, anencephaly and left heart underdevelopment), 2 for detected chromosome defects and 3 for maternal reasons (major illness in 2).By the end of the post-pregnancy year a further 99 pregnancies had become unavailable for follow-up (resulting in an 84.9% live-born infant final retention rate). An additional 33 pregnancies that had resulted in late recognised foetal malformations had been identified, nearly all in the first 6 months after birth. Intrauterine valproate exposure was involved in 447 of the 1731 antiepileptic drug treated pregnancies, a malformation-carrying pregnancy rate of 11.86%, as compared with a rate of 2.70% in the 148 drug-unexposed pregnancies (O.R. = 4.84; 95% C.I. 1.72, 13.62), used as comparators.ConclusionThis report confirms previous interpretations of the APR data, also providing insights into the pregnancies of women with epilepsy that did not result in live- born offspring.

scholarly journals Antiepileptic drugs, foetal malformations and spontaneous abortions

2016 ◽  
Vol 135 (3) ◽  
pp. 360-365 ◽  
Author(s):  
F. J. E. Vajda ◽  
T. J. O'Brien ◽  
J. E. Graham ◽  
A. A. Hitchcock ◽  
C. M. Lander ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Spontaneous Abortions ◽  
Foetal Malformations

scholarly journals Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Catherine Fallet-Bianco ◽  
Annie Laquerrière ◽  
Karine Poirier ◽  
Ferechte Razavi ◽  
Fabien Guimiot ◽  
...  
Keyword(s):  
Cortical Development ◽  
Malformations Of Cortical Development ◽  
Tubulin Genes ◽  
Foetal Malformations

650: Dose-dependence of antiepileptic drug associated foetal malformations

2007 ◽  
Vol 14 (10) ◽  
pp. 1036
Author(s):  
Frank Vajda ◽  
Terence J. O’Brien ◽  
A. Hitchcock ◽  
J. Graham ◽  
C. Lander ◽  
...  
Keyword(s):  
Antiepileptic Drug ◽  
Dose Dependence ◽  
Foetal Malformations

Foetal malformations after exposure to antiepileptic drugs in utero assessed at birth and 12 months later: observations from the Australian pregnancy register

2010 ◽  
Vol 124 (1) ◽  
pp. 9-12 ◽  
Author(s):  
F. J. E. Vajda ◽  
J. Graham ◽  
A. A. Hitchcock ◽  
T. J. O'Brien ◽  
C. M. Lander ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
In Utero ◽  
Foetal Malformations
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