How routine pharmacovigilance failed to identify finasteride's persistent sexual side effects

Andrology ◽  
2021 ◽  
Author(s):  
Michael S Irwig
Keyword(s):  
Side Effects ◽  
Sexual Side Effects

Is There A Role For Lifestyle Interventions In Obsessive-Compulsive And Related Disorders?

2019 ◽  
Vol 25 (41) ◽  
pp. 5698-5711 ◽  
Author(s):  
Leonardo F. Fontenelle ◽  
Maiara Zeni-Graiff ◽  
Julliana N. Quintas ◽  
Murat Yücel
Keyword(s):  
Side Effects ◽  
Eating Behaviors ◽  
Lifestyle Interventions ◽  
Partial Hospitalization ◽  
Obsessive Compulsive ◽  
Life Styles ◽  
Current State ◽  
Sexual Side Effects ◽  
Augmentation Strategies ◽  
Compulsive Disorders

Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunately, the application of these treatments in milder forms of illness and subclinical samples, which affect a substantial portion of the population, is not justifiable by their costs (e.g. cognitivebehavioral therapy) and/or potential for side effects (serotonin-reuptake inhibitors associated sexual side effects). As such, there is an urgent need to develop simple yet effective treatments, such as modifiable lifestyle interventions, that can be employed on a broader scale. Here, we review the current state of evidence that supports or refutes the efficacy of lifestyle approaches for OCRDs. We focus on dimensions of lifestyle that are deemed important for cardiovascular diseases; namely, physical activity, stress, sleep, diet and eating behaviors, alcohol consumption, and smoking. Despite the relative scarcity of welldesigned randomized controlled trials targeting unhealthy life styles in OCRDs, we found meditation-based therapies and interventions focusing on eliminating sedentarism to be promising approaches. In the future, these strategies may represent valid alternative for subjects with subthreshold symptoms or at risk for OCRDs or other “compulsive” disorders.

Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline*

1997 ◽  
Vol 61 (4) ◽  
pp. 478-487 ◽  
Author(s):  
Jack G. Modell ◽  
Charles R. Katholi ◽  
Judith D. Modell ◽  
R. Lawrence DePalma
Keyword(s):  
Side Effects ◽  
Sexual Side Effects

Antialdosterones: Incidence and prevention of sexual side effects

1989 ◽  
Vol 32 (1) ◽  
pp. 223-227 ◽  
Author(s):  
M. De Gasparo ◽  
S.E. Whitebread ◽  
G. Preiswerk ◽  
X. Jeunemaître ◽  
P. Corvol ◽  
...  
Keyword(s):  
Side Effects ◽  
Sexual Side Effects

Sexual Dysfunction

2014 ◽  
pp. 97-98
Author(s):  
David L Brody
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Drug Abuse ◽  
Side Effects ◽  
Sexual Dysfunction ◽  
Pde5 Inhibitor ◽  
Cauda Equina ◽  
Sexual Side Effects ◽  
Severe Fatigue ◽  
Cord Injury

This chapter addresses issues surrounding sexual dysfunction after concussion. Ask the patient specifically about sexual dysfunction in private, and if appropriate ask the collateral source separately. Assess for depression, severe fatigue or hypersomnia, untreated pain, and alcohol or drug abuse (especially marijuana). Check medications for sexual side effects; serotonin specific reuptake inhibitors are the most common culprits. Test for hormonal imbalances and unrecognized cauda equina or lower spinal cord injury. Consider a trial of a PDE5 inhibitor and refer to urology for more advanced options.

scholarly journals Mapping the prevalence of the neglected sexual side effects after prostate cancer treatment and the questionnaires used in their screening: a scoping review protocol

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Pierre Röscher ◽  
Jacqueline M. van Wyk
Keyword(s):  
Prostate Cancer ◽  
Side Effects ◽  
Scoping Review ◽  
Research Question ◽  
Prostate Cancer Treatment ◽  
Eligibility Criteria ◽  
Sexual Stimulation ◽  
Sexual Side Effects ◽  
Review Team ◽  
Review Protocol

Abstract Background Interventions to treat early prostate cancer (PCa) can leave men with debilitating sexual side effects. The cluster of side effects referred to as the neglected sexual side effects (NSSE) may remain permanent, undiagnosed and untreated because men are hesitant to disclose them. Questionnaires offer a discreet way into the discussion, subsequent diagnosis and possible treatment of the NSSE. This study will be conducted to map the evidence about the prevalence of the neglected sexual side effects (NSSE) after PCa treatment, and use of questionnaires in its diagnosis and screening. Methods This systematic scoping review will involve searching the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Eligibility criteria will guide the screenings. Data will be extracted from the included studies, and the emerging themes will be analysed. The review team will analyse the implications of the findings concerning the research question and aim of the study. The mixed method appraisal tool (MMAT) will be employed for quality appraisal of included studies. Discussion We anticipate finding a number of studies that describe the prevalence of NSSE after early PCa treatment and that report on using questionnaires to screen for the presence of symptoms including orgasm-associated incontinence, urinary incontinence during sexual stimulation, altered perceptions of orgasm, orgasm associated pain, penile shortening and penile deformity. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations and presentations at relevant conferences.

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