Fatty liver index is associated with the risk of testosterone deficiency in aging men without metabolic syndrome

Andrology ◽  
2021 ◽  
Author(s):  
Chia‐Chu Liu ◽  
Shu‐Pin Huang ◽  
Tusty‐Jiuan Hsieh ◽  
Cheng‐Hsueh Lee ◽  
Kai‐Hung Cheng ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Testosterone Deficiency ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Aging Men

Fatty liver index as an indicator of metabolic syndrome

2012 ◽  
Vol 45 (1-2) ◽  
pp. 68-71 ◽  
Author(s):  
Dinko Rogulj ◽  
Paško Konjevoda ◽  
Mirta Milić ◽  
Marin Mladinić ◽  
Ana-Marija Domijan
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Liver Index ◽  
Fatty Liver Index

scholarly journals An observational study of the evaluation of fatty liver in non-alcoholics with metabolic syndrome using fatty liver index and its correlation with USG elastography

2020 ◽  
Vol 7 (4) ◽  
pp. 673
Author(s):  
Vaishnavi Danasekaran ◽  
M. Narayanan
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Waist Circumference ◽  
Fatty Liver ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Alcoholic Fatty Liver ◽  
Liver Index ◽  
Fatty Liver Index

Background: NAFLD (Non Alcoholic Fatty Liver Disease) is being considered the hepatic component of metabolic syndrome. It is now the most common cause of chronic liver disease worldwide and needs to be addressed urgently as it is asymptomatic and widely prevalent and can progress to cirrhosis and hepatocellular carcinoma. There is a need for simpler methods to diagnose the condition in modern day practice which will help in identifying vulnerable subjects and in bringing  about awareness and lifestyle modifications focused on reversal of the condition. Aim of this study was to check the applicability of the fatty liver index in modern day out patient practice using formula based FLI calculator.Methods: It was a cross sectional study on patients with metabolic syndrome in a tertiary care hospital. 60 patients with metabolic syndrome, both male and female above the age of 30 years and who were non-alcoholics were enrolled in the study. BMI, waist circumference, lipid profile and GGT were obtained and FLI calculated. It was compared with the ultrasound and Elastography reports. Chi square test, Independent t test and ANOVA test were used for comparing parameters. A p value of <0.05 was considered statistically significant.Results: Among 60 patients all had fatty liver which emphasizes that fatty liver is the hepatic component of metabolic syndrome. There is a significant correlation between BMI (Body Mass Index) and waist circumference in predicting fatty liver and to some extent its grade. Patients with higher BMI had a greater grade of fatty liver.Conclusions: The fatty liver index is a reliable predictor of fatty liver in people with metabolic syndrome. The grade of fatty liver increases with increase in waist circumference and increased BMI. Ultrasound and Elastography are reliable non invasive methods of detecting fatty liver. BMI and Waist circumference are strong predictive factors for fatty liver.

scholarly journals Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e026949 ◽  
Author(s):  
Olubunmi Olujimisola Olubamwo ◽  
Jyrki K Virtanen ◽  
Jussi Pihlajamaki ◽  
Tomi-Pekka Tuomainen
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Metabolic Factors ◽  
Incident Type ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Incident Type 2 Diabetes ◽  
Eastern Finland

ObjectiveFatty liver disease (FLD) is increasingly recognised as a predictor of cardiometabolic risk. Our objective was to examine if metabolic syndrome (MS) status affects the association of FLD with incident type 2 diabetes (T2D) in middle-aged men.DesignProspective epidemiological study.SettingUniversity affiliated research centre in Kuopio, Eastern Finland.ParticipantsOur subjects were 1792 Finnish men without diabetes at baseline in the KuopioIschaemicHeart Disease Risk Factor Study cohort.Outcome measureUsing fatty liver index (FLI), the association of baseline FLD with incident T2D was analysed in multivariable-adjusted Cox regression models, considering their MS statuses. The main models were adjusted for constitutional factors, lifestyle factors, biomarkers of inflammation and for high (FLI ≥60) versus low (FLI <30) FLI categories.ResultsDuring a mean follow-up of 19 years, 375 incident cases of T2D were recorded. In the full model, the HR (HR (95% CI)) for T2D was 3.68 (2.80 to 4.82). The association was attenuated, but maintained, with further adjustment for metabolic factors. When MS status was adjusted for in place of metabolic factors, the HRs (95% CIs) were 2.63 (1.92 to 3.59) for FLI ≥60 and 1.77 (1.35 to 2.31) for MS.In MS-stratified analysis, FLI predicted T2D only among persons without MS. In unstratified analysis with subjects categorised by FLI-MS, persons with FLI ≥60 without MS had increased risk for T2D (HR=3.19 (2.26 to 4.52)) compared with persons with FLI <30 without MS. Persons with FLI <30 and MS had greater risk (HR=4.31 (2.15 to 8.61)) and persons with both FLI ≥60 and MS had the greatest risk (HR=4.66 (3.42 to 6.35)).ConclusionGenerally, FLD (FLI ≥60) predicts T2D. It specifically predicted T2D among men without MS but not among men with MS, for whom MS alone already increases the risk. Both FLI and MS can complement each other in screening and surveillance for persons with increased T2D risk.

scholarly journals Fatty Liver Index and Lipid Accumulation Product Can Predict Metabolic Syndrome in Subjects without Fatty Liver Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Yuan-Lung Cheng ◽  
Yuan-Jen Wang ◽  
Keng-Hsin Lan ◽  
Teh-Ia Huo ◽  
Yi-Hsiang Huang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Accumulation ◽  
Fatty Liver Disease ◽  
Lipid Accumulation Product ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Better Than

Background. Fatty liver index (FLI) and lipid accumulation product (LAP) are indexes originally designed to assess the risk of fatty liver and cardiovascular disease, respectively. Both indexes have been proven to be reliable markers of subsequent metabolic syndrome; however, their ability to predict metabolic syndrome in subjects without fatty liver disease has not been clarified.Methods. We enrolled consecutive subjects who received health check-up services at Taipei Veterans General Hospital from 2002 to 2009. Fatty liver disease was diagnosed by abdominal ultrasonography. The ability of the FLI and LAP to predict metabolic syndrome was assessed by analyzing the area under the receiver operating characteristic (AUROC) curve.Results. Male sex was strongly associated with metabolic syndrome, and the LAP and FLI were better than other variables to predict metabolic syndrome among the 29,797 subjects. Both indexes were also better than other variables to detect metabolic syndrome in subjects without fatty liver disease (AUROC: 0.871 and 0.879, resp.), and the predictive power was greater among women.Conclusion. Metabolic syndrome increases the cardiovascular disease risk. The FLI and LAP could be used to recognize the syndrome in both subjects with and without fatty liver disease who require lifestyle modifications and counseling.

1907-P: GLP-1RA and iSGLT2 Combination Treatment Effects over Fatty Liver Index

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1907-P
Author(s):  
JUANA CARRETERO GÓMEZ ◽  
JOSE CARLOS AREVALO LORIDO ◽  
RICARDO GÓMEZ-HUELGAS ◽  
JOSÉ MIGUEL SEGUÍ-RIPOLL ◽  
MANUEL SUAREZ TEMBRA ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Combination Treatment ◽  
Treatment Effects ◽  
Liver Index ◽  
Fatty Liver Index

2306-PUB: Serum CXCL14 Levels Are Associated with Plasma C-Peptide and Fatty Liver Index in T2DM Patients: A Retrospective Analysis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2306-PUB
Author(s):  
YURIKO MATSUSHITA ◽  
YUTAKA HASEGAWA ◽  
NORIKO TAKEBE ◽  
YASUSHI ISHIGAKI
Keyword(s):  
Fatty Liver ◽  
Retrospective Analysis ◽  
C Peptide ◽  
Liver Index ◽  
Fatty Liver Index

scholarly journals High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yukimura Higashiura ◽  
Masato Furuhashi ◽  
Marenao Tanaka ◽  
Satoko Takahashi ◽  
Masayuki Koyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Liver ◽  
Male And Female ◽  
Nonalcoholic Fatty Liver ◽  
Liver Index ◽  
Fatty Liver Index ◽  
History Of ◽  
Onset Of Diabetes ◽  
High Level ◽  
New Onset

AbstractFatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.

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