Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production

Andrology ◽  
2020 ◽  
Author(s):  
Gustavo Marcelo Rindone ◽  
Agostina Gorga ◽  
Eliana Herminia Pellizzari ◽  
María del Carmen Camberos ◽  
María Noel Galardo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sertoli Cell ◽  
Metformin Treatment ◽  
Sperm Production ◽  
Daily Sperm Production

scholarly journals Neonatal hypothyroidism does not increase Sertoli cell proliferation in iNOS−/− mice

Reproduction ◽  
2017 ◽  
Vol 154 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Nathália L M Lara ◽  
Luiz R França
Keyword(s):  
Thyroid Hormones ◽  
Sertoli Cell ◽  
Leydig Cells ◽  
Testis Size ◽  
Additive Effects ◽  
Sperm Production ◽  
Wild Type ◽  
Neonatal Hypothyroidism ◽  
Laboratory Rodents ◽  
Daily Sperm Production

Sertoli cell (SC) proliferation in mice occurs until two weeks after birth and is mainly regulated by FSH and thyroid hormones. Previous studies have shown that transient neonatal hypothyroidism in laboratory rodents is able to extend SC mitotic activity, leading ultimately to higher testis size and daily sperm production (DSP) in adult animals. Moreover, we have shown that due to higher SC proliferation and lower germ cell apoptosis, iNOS deficiency in mice also results in higher testis size and DSP. Although the cell size was smaller, the Leydig cells (LCs) number per testis also significantly increased in iNOS−/−mice. Our aims in the present study were to investigate if the combination of neonatal hypothyroidism and iNOS deficiency promotes additive effects in SC number, testis size and DSP. Hypothyroidism was induced in wild-type (WT) and iNOS−/−mice using 6-propyl-2-thiouracil (PTU) through the mother’s drinking water from 0 to 20 days of age, and were sacrificed at adulthood. Our results showed that, in contrast to the WT mice in which testis size, DSP and SC numbers increased significantly by 20, 40 and 70% respectively, after PTU treatment, no additive effects were observed for these parameters in treated iNOS−/−mice, as well as for LC. No alterations were observed in spermatogenesis in any group evaluated. Although we still do not have an explanation for these intriguing findings, we are currently investigating whether thyroid hormones influence iNOS levels and/or counterbalance physiological effects of iNOS deficiency in testis function and spermatogenesis.

scholarly journals Tumor Suppressor PTEN Regulates Negatively Sertoli Cell Proliferation, Testis Size, and Sperm Production In Vivo

Endocrinology ◽  
2018 ◽  
Vol 160 (2) ◽  
pp. 387-398 ◽  
Author(s):  
Yasmine Neirijnck ◽  
Françoise Kühne ◽  
Chloé Mayère ◽  
Ekaterina Pavlova ◽  
Pauline Sararols ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Suppressor ◽  
Sertoli Cell ◽  
Testis Size ◽  
Sperm Production

scholarly journals Number and function of Sertoli cells, number and yield of spermatogonia, and daily sperm production in three breeds of boar

Reproduction ◽  
1996 ◽  
Vol 107 (1) ◽  
pp. 137-149 ◽  
Author(s):  
O. E. Okwun ◽  
G. Igboeli ◽  
J. J. Ford ◽  
D. D. Lunstra ◽  
L. Johnson
Keyword(s):  
Sertoli Cells ◽  
Sperm Production ◽  
And Function ◽  
Daily Sperm Production
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