Activation of the cannabinoid receptor type 2 by the agonist JWH133 promotes the first wave of in vitro spermatogenesis

Andrology ◽  
2020 ◽  
Author(s):  
Ludovic Dumont ◽  
Marion Delessard ◽  
Justine Saulnier ◽  
Aurélie Rives ◽  
Christine Rondanino ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
In Vitro Spermatogenesis ◽  
Cannabinoid Receptor Type 2

Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro

2013 ◽  
Vol 33 (5) ◽  
pp. 566-570 ◽  
Author(s):  
Lysanne Campeau ◽  
Claudius Füllhase ◽  
Norifumi Sawada ◽  
Christian Gratzke ◽  
Petter Hedlund ◽  
...  
Keyword(s):  
Knockout Mouse ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Bladder Function ◽  
Cannabinoid Receptor Type 2

Involvement of cannabinoid receptor type 2 in light-induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo

2018 ◽  
Vol 167 ◽  
pp. 44-50 ◽  
Author(s):  
Tomoyo Imamura ◽  
Kazuhiro Tsuruma ◽  
Yuki Inoue ◽  
Tomohiro Otsuka ◽  
Yuta Ohno ◽  
...  
Keyword(s):  
Cell Line ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Retinal Cell ◽  
Cannabinoid Receptor Type 2

scholarly journals Cannabinoid receptor type 2 gene is associated with human osteoporosis

2005 ◽  
Vol 14 (22) ◽  
pp. 3389-3396 ◽  
Author(s):  
Meliha Karsak ◽  
Martine Cohen-Solal ◽  
Jan Freudenberg ◽  
Agnes Ostertag ◽  
Caroline Morieux ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals Cannabinoid Receptor Type 2 (CB2) Dependent and Independent Effects of WIN55,212-2 on Atherosclerosis in Ldlr-null Mice

2015 ◽  
Vol 3 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Douglas Thewke ◽  
◽  
Courtney Netherland-Van Dyke ◽  
Ward Rodgers ◽  
Makenzie Fulmer ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2 ◽  
Independent Effects

scholarly journals Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?

2020 ◽  
Vol 21 (11) ◽  
pp. 3809 ◽  
Author(s):  
Francesca Rossi ◽  
Chiara Tortora ◽  
Maura Argenziano ◽  
Alessandra Di Paola ◽  
Francesca Punzo
Keyword(s):  
Cannabinoid Receptor ◽  
Protective Role ◽  
Receptor Type ◽  
Macrophage Phenotype ◽  
Small Vessels ◽  
Global Pandemic ◽  
Cannabinoid Receptor Type 2 ◽  
Novel Coronavirus

In late December 2019, a novel coronavirus (SARS-CoV-2 or CoV-19) appeared in Wuhan, China, causing a global pandemic. SARS-CoV-2 causes mild to severe respiratory tract inflammation, often developing into lung fibrosis with thrombosis in pulmonary small vessels and causing even death. COronaVIrus Disease (COVID-19) patients manifest exacerbated inflammatory and immune responses, cytokine storm, prevalence of pro-inflammatory M1 macrophages and increased levels of resident and circulating immune cells. Men show higher susceptibility to SARS-CoV-2 infection than women, likely due to estrogens production. The protective role of estrogens, as well as an immune-suppressive activity that limits the excessive inflammation, can be mediated by cannabinoid receptor type 2 (CB2). The role of this receptor in modulating inflammation and immune response is well documented in fact in several settings. The stimulation of CB2 receptors is known to limit the release of pro-inflammatory cytokines, shift the macrophage phenotype towards the anti-inflammatory M2 type and enhance the immune-modulating properties of mesenchymal stromal cells. For these reasons, we hypothesize that CB2 receptor can be a therapeutic target in COVID-19 pandemic emergency.

scholarly journals Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics

2020 ◽  
Vol 57 (6) ◽  
pp. 2830-2845 ◽  
Author(s):  
Ying Yu ◽  
Lexiao Li ◽  
Davis T. Nguyen ◽  
Suni M. Mustafa ◽  
Bob M. Moore ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Neuroprotective Effects ◽  
Inverse Agonism ◽  
Cannabinoid Receptor Type 2 ◽  
Anti Inflammatory
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