Loss of glutathione peroxidase 3 induces ROS and contributes to prostatic hyperplasia in Nkx3.1 knockout mice

Andrology ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 1486-1493
Author(s):  
Ukjin Kim ◽  
C‐Yoon Kim ◽  
Ji Min Lee ◽  
Bokyeong Ryu ◽  
Jin Kim ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Knockout Mice ◽  
Prostatic Hyperplasia ◽  
Glutathione Peroxidase 3

scholarly journals Silencing of Glutathione Peroxidase 3 through DNA Hypermethylation Is Associated with Lymph Node Metastasis in Gastric Carcinomas

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46214 ◽  
Author(s):  
Dun-Fa Peng ◽  
Tian-Ling Hu ◽  
Barbara G. Schneider ◽  
Zheng Chen ◽  
Ze-Kuan Xu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Glutathione Peroxidase ◽  
Dna Hypermethylation ◽  
Gastric Carcinomas ◽  
Node Metastasis ◽  
Glutathione Peroxidase 3

scholarly journals Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence

Theranostics ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 212-222 ◽  
Author(s):  
Xiang Qi ◽  
Kevin Tak-Pan Ng ◽  
Qizhou Lian ◽  
Chang Xian Li ◽  
Wei Geng ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Glutathione Peroxidase 3

Osmotically stress-regulated the expression of glutathione peroxidase 3 in Arabidopsis

2007 ◽  
Vol 52 (1) ◽  
pp. 127-130 ◽  
Author(s):  
YuChen Miao ◽  
JingGong Guo ◽  
ErTao Liu ◽  
Kun Li ◽  
Jie Dai ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Glutathione Peroxidase 3

Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill?

2008 ◽  
Vol 35 (5) ◽  
pp. 882-889 ◽  
Author(s):  
William Manzanares ◽  
Alberto Biestro ◽  
Federico Galusso ◽  
Maria H. Torre ◽  
Nelly Mañay ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Critically Ill ◽  
Systemic Inflammation ◽  
Serum Selenium ◽  
Glutathione Peroxidase 3

scholarly journals Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mona M. Mohamed ◽  
Salwa Sabet ◽  
Dun-Fa Peng ◽  
M. Akram Nouh ◽  
Mohamed El-Shinawi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glutathione Peroxidase ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Ductal Carcinoma ◽  
Methylation Status ◽  
Promoter Hypermethylation ◽  
Normal Breast ◽  
Glutathione Peroxidase 3 ◽  
Breast Tissues

Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression. Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth. Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression. Although the role of GPX3 has been studied in different cancer types, its role in breast cancer and its epigenetic regulation have not yet been investigated. The aim of the present study was to investigate GPX3 expression and epigenetic regulation in carcinoma tissues of breast cancer patients’ in comparison to normal breast tissues. Furthermore, we compared GPX3 level of expression and methylation status in aggressive phenotype inflammatory breast cancer (IBC) versus non-IBC invasive ductal carcinoma (IDC). We found that GPX3 mRNA and protein expression levels were downregulated in the carcinoma tissues of IBC compared to non-IBC. However, we did not detect significant correlation between GPX3 and patients’ clinical-pathological prosperities. Promoter hypermethylation of GPX3 gene was detected in carcinoma tissues not normal breast tissues. In addition, IBC carcinoma tissues showed a significant increase in the promoter hypermethylation of GPX3 gene compared to non-IBC. Our results propose that downregulation of GPX3 in IBC may play a role in the disease progression.

Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3

2007 ◽  
Vol 388 (10) ◽  
Author(s):  
Cornelia Schmutzler ◽  
Birgit Mentrup ◽  
Lutz Schomburg ◽  
Cuong Hoang-Vu ◽  
Volker Herzog ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Glutathione Peroxidase ◽  
Glutathione Peroxidase 3
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