Notch signaling regulates nuclear androgen receptor AR and membrane androgen receptor ZIP 9 in mouse Sertoli cells

Andrology ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 457-472 ◽  
Author(s):  
A. Kamińska ◽  
L. Pardyak ◽  
S. Marek ◽  
K. Wróbel ◽  
M. Kotula‐Balak ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Notch Signaling ◽  
Sertoli Cells ◽  
Membrane Androgen Receptor

Expression and localization of androgen receptor-interacting protein-4 in the testis

2007 ◽  
Vol 292 (2) ◽  
pp. E513-E522 ◽  
Author(s):  
Andrii Domanskyi ◽  
Fu-Ping Zhang ◽  
Mirja Nurmio ◽  
Jorma J. Palvimo ◽  
Jorma Toppari ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cell ◽  
Germ Cells ◽  
Sertoli Cells ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Dependent Manner ◽  
Cell Nuclei ◽  
Interacting Protein ◽  
Independent Functions

Androgen receptor-interacting protein 4 (ARIP4) belongs to the SNF2 family of proteins involved in chromatin remodeling, DNA excision repair, and homologous recombination. It is a DNA-dependent ATPase, binds to DNA and mononucleosomes, and interacts with androgen receptor (AR) and modulates AR-dependent transactivation. We have examined in this study the expression and cellular localization of ARIP4 during postnatal development of mouse testis. ARIP4 was detected by immunohistochemistry in Sertoli cell nuclei at all ages studied, starting on day 5, and exhibited the highest expression level in adult mice. At the onset of spermatogenesis, ARIP4 expression became evident in spermatogonia, pachytene, and diplotene spermatocytes. Immunoreactive ARIP4 antigen was present in Leydig cell nuclei. In Sertoli cells ARIP4 was expressed in a stage-dependent manner, with high expression levels at stages II–VI and VII–VIII. ARIP4 expression patterns did not differ significantly in testes of wild-type, follicle-stimulating hormone receptor knockout, and luteinizing hormone receptor knockout mice. In testes of hypogonadal mice, ARIP4 was found mainly in interstitial cells and exhibited lower expression in Sertoli and germ cells. In vitro stimulation of rat seminiferous tubule segments with testosterone, FSH, or forskolin did not significantly change stage-specific levels of ARIP4 mRNA. Heterozygous ARIP4+/− mice were haploinsufficient and had reduced levels of Sertoli-cell specific androgen-regulated Rhox5 (also called Pem) mRNA. Collectively, ARIP4 is an AR coregulator in Sertoli cells in vivo, but the expression in the germ cells implies that it has also AR-independent functions in spermatogenesis.

Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells

2008 ◽  
Vol 314 (17) ◽  
pp. 3162-3174 ◽  
Author(s):  
N PAPADOPOULOU ◽  
I CHARALAMPOPOULOS ◽  
K ALEVIZOPOULOS ◽  
A GRAVANIS ◽  
C STOURNARAS
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Membrane Androgen Receptor

scholarly journals Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor

FEBS Journal ◽  
2012 ◽  
Vol 279 (7) ◽  
pp. 1231-1242 ◽  
Author(s):  
Eva-Maria Schmidt ◽  
Shuchen Gu ◽  
Vasileia Anagnostopoulou ◽  
Konstantinos Alevizopoulos ◽  
Michael Föller ◽  
...  
Keyword(s):  
Cell Migration ◽  
Androgen Receptor ◽  
Membrane Androgen Receptor

scholarly journals Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor Corepressor

2005 ◽  
Vol 25 (4) ◽  
pp. 1425-1436 ◽  
Author(s):  
Borja Belandia ◽  
Sue M. Powell ◽  
Juana M. García-Pedrero ◽  
Marjorie M. Walker ◽  
Charlotte L. Bevan ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Notch Signaling ◽  
Target Genes ◽  
Active Form ◽  
Prostatic Hyperplasia ◽  
Transcriptional Repressors ◽  
Marked Contrast ◽  
Hormonal Responses ◽  
Helix Loop Helix ◽  
Prostate Cancers

ABSTRACT Hey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling. Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR). Our results indicate that Hey1 functions as a corepressor for AF1 in the AR, providing a mechanism for cross talk between Notch and androgen-signaling pathways. Hey1 colocalizes with AR in the epithelia of patients with benign prostatic hyperplasia, where it is found in both the cytoplasm and the nucleus. In marked contrast, we demonstrate that Hey1 is excluded from the nucleus in most human prostate cancers, raising the possibility that an abnormal Hey1 subcellular distribution may have a role in the aberrant hormonal responses observed in prostate cancer.

Preclinical studies of MDX-12C, a selective membrane androgen receptor ligand with activity in prostate cancer

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 14549-14549 ◽  
Author(s):  
K. Alevizopoulos ◽  
N. Bacopoulos ◽  
N. Papadopoulou ◽  
K. Dambaki ◽  
C. Stournaras
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Preclinical Studies ◽  
Receptor Ligand ◽  
Selective Membrane ◽  
Membrane Androgen Receptor

Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells

1989 ◽  
Vol 63 (1-2) ◽  
pp. 267-271 ◽  
Author(s):  
Leen J. Blok ◽  
Petra Mackenbach ◽  
Jan Trapman ◽  
Axel P.N. Themmen ◽  
Albert O. Brinkmann ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cells ◽  
Follicle Stimulating Hormone ◽  
Receptor Mrna ◽  
Stimulating Hormone

scholarly journals Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
D. Fietz ◽  
M. Markmann ◽  
D. Lang ◽  
L. Konrad ◽  
J. Geyer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Androgen Receptor ◽  
Sertoli Cells
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