scholarly journals Comprehensive insight into functional interaction between GNB3 C825T and eNOS T-786C, G894T gene polymorphisms and association with susceptibility to diabetic erectile dysfunction

Andrology ◽  
2018 ◽  
Vol 6 (6) ◽  
pp. 865-873 ◽  
Author(s):  
M. R. Ben Khedher ◽  
M. Abid ◽  
K. Jamoussi ◽  
M. Hammami
Keyword(s):  
Erectile Dysfunction ◽  
Gene Polymorphisms ◽  
Functional Interaction ◽  
Gnb3 C825t ◽  
Insight Into

scholarly journals Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer in a Chinese Han population

2020 ◽  
Author(s):  
Ying Duan ◽  
Gaowen Liu ◽  
Fanglin Niu ◽  
Jing Li ◽  
Mengdan Yan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Odds Ratio ◽  
Gene Polymorphisms ◽  
Additive Model ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Han Population ◽  
Codominant Model ◽  
Insight Into

Abstract Background The aim of this study was to investigate the effects of COL6A4P2 polymorphisms on lung cancer (LC) in Chinese Han population.Methods To examine whether variants of COL6A4P2 contribute to LC, five single nucleotide polymorphisms (SNPs) of COL6A4P2 were genotyped by Agena MassARRAY in 510 LC patients and 495 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression.Results We found that COL6A4P2 rs34445363 significantly increased the risk of LC in the alleles model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.038). And rs34445363 also increased the LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.041) with the multigene model analysis. Further stratification analysis showed that rs34445363 increased the LC risk under the log-additive model (OR = 1.42, 95%CI: 1.03 - 1.95, p = 0.033) in people aged ≤ 61; and rs61733464 was associated with a decreased LC risk in the log-additive model (OR = 0.72, 95%CI: 0.52 - 0.99, p = 0.048) in people aged ≤ 61. We also found that the mutations of rs34445363 and rs77941834 were associated with increased LC risk in the codominant model (rs34445363, GA vs. GG, OR = 1.73, 95%CI: 1.04 - 2.86, p = 0.034; rs77941834, TA vs. TT, OR = 1.88, 95%CI: 1.06 - 3.34, p = 0.032) in females.Conclusions This study provided an evidence for polymorphisms of COL6A4P2 gene associated to the development of LC, also a new insight into etiology of LC.

scholarly journals Gene Polymorphisms in Chronic Periodontitis

2010 ◽  
Vol 2010 ◽  
pp. 1-22 ◽  
Author(s):  
Marja L. Laine ◽  
Bruno G. Loos ◽  
W. Crielaard
Keyword(s):  
Risk Factors ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Control Design ◽  
Rare Allele ◽  
Case Control ◽  
Review Of The Literature ◽  
Genotype Frequencies ◽  
Comprehensive Search ◽  
Insight Into

We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in theIL1, IL6, IL10, vitamin D receptor, andCD14genes may be associated with CP in certain populations. However, carriage rates of the rare -allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.

scholarly journals Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses

2008 ◽  
Vol 89 (4) ◽  
pp. 975-983 ◽  
Author(s):  
Miranda de Graaf ◽  
Sander Herfst ◽  
Eefje J. A. Schrauwen ◽  
Ying Choi ◽  
Bernadette G. van den Hoogen ◽  
...  
Keyword(s):  
Protein Composition ◽  
Polymerase Activity ◽  
Functional Interaction ◽  
Avian Metapneumovirus ◽  
Polymerase Complex ◽  
Syncytial Virus ◽  
Bovine Parainfluenza Virus ◽  
Similar Genome Organization ◽  
Insight Into

Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like molecules representing HMPV-A1 and -B1, AMPV-A and -C and human respiratory syncytial virus were replicated efficiently by polymerase complexes of HMPV-A1 and -B1 and AMPV-C, but not by polymerase complexes of bovine parainfluenza virus 3. Upon exchange of HMPV and AMPV-C polymerase complex components, all chimeric polymerase complexes were functional; exchange between HMPVs did not result in altered polymerase activity, whereas exchange between HMPVs and AMPV-C did. Recombinant HMPV-B1 viruses in which polymerase genes were exchanged with those of HMPV-A1 replicated with normal kinetics in vitro, whilst replacement with AMPV-C genes resulted in moderate differences in virus replication. In hamsters, recombinant HMPV-B1 viruses in which individual polymerase genes were exchanged with those of AMPV-C were attenuated, irrespective of the results obtained with minireplicon systems or in vitro replication assays. This study provides insight into the specificity and functional interaction of polymerase complex proteins of human and avian metapneumoviruses, but neither minireplicon systems nor in vitro replication kinetics were found to be predictive for attenuation in permissive animals.

ORIGINAL RESEARCH—BASIC SCIENCE: The Associations among GNB3 C825T Polymorphism, Erectile Dysfunction, and Related Risk Factors

2008 ◽  
Vol 5 (9) ◽  
pp. 2061-2068 ◽  
Author(s):  
Yung‐Chin Lee ◽  
Hui‐Hui Lin ◽  
Chii‐Jye Wang ◽  
Chia‐Chu Liu ◽  
Wen‐Jeng Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Basic Science ◽  
Original Research ◽  
Related Risk ◽  
C825t Polymorphism ◽  
Gnb3 C825t

scholarly journals Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain

Gene X ◽  
2019 ◽  
Vol 1 ◽  
pp. 100005
Author(s):  
Ana Segura ◽  
Pura Ballester ◽  
Raquel Ajo ◽  
María-del-Mar Inda ◽  
Antonio Urbano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Pain ◽  
Erectile Dysfunction ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Gene Polymorphisms Affecting Erectile Dysfunction

2020 ◽  
Vol 8 (4) ◽  
pp. 561-572
Author(s):  
Taymour Mostafa ◽  
Mai Taymour
Keyword(s):  
Erectile Dysfunction ◽  
Gene Polymorphisms
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