scholarly journals Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury

Andrology ◽  
2018 ◽  
Vol 6 (6) ◽  
pp. 927-935 ◽  
Author(s):  
M. Li ◽  
H. Lei ◽  
Y. Xu ◽  
H. Li ◽  
B. Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Cavernous Nerves

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

2013 ◽  
Vol 125 (4) ◽  
pp. 199-210 ◽  
Author(s):  
Sandra Villanueva ◽  
Juan E. Carreño ◽  
Lorena Salazar ◽  
César Vergara ◽  
Rocío Strodthoff ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Smooth Muscle Actin ◽  
Human Mesenchymal Stem Cells ◽  
Plasma Creatinine ◽  
Sprague Dawley ◽  
Alternative Source

Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce proteinuria, but not diminish the disease progression. We have demonstrated beneficial effects by injection of BM (bone marrow)-derived MSCs (mesenchymal stem cells) from healthy donors in a rat model with CKD. However, it has recently been reported that BM-MSCs derived from uraemic patients failed to confer functional protection in a similar model. This suggests that autologous BM-MSCs are not suitable for the treatment of CKD. In the present study, we have explored the potential of MSCs derived from adipose tissue (AD-MSCs) as an alternative source of MSCs for the treatment of CKD. We have isolated AD-MSCs and evaluated their effect on the progression of CKD. Adult male SD (Sprague–Dawley) rats subjected to 5/6 NPX (nephrectomy) received a single intravenous infusion of 0.5×106 AD-MSCs or MSC culture medium alone. The therapeutic effect was evaluated by plasma creatinine measurement, structural analysis and angiogenic/epitheliogenic protein expression. AD-MSCs were detected in kidney tissues from NPX animals. This group had a significant reduction in plasma creatinine levels and a lower expression of damage markers ED-1 and α-SMA (α-smooth muscle actin) (P<0.05). In addition, treated rats exhibited a higher level of epitheliogenic [Pax-2 and BMP-7 (bone morphogenetic protein 7)] and angiogenic [VEGF (vascular endothelial growth factor)] proteins. The expression of these biomarkers of regeneration was significantly related to the improvement in renal function. Although many aspects of the cell therapy for CKD remain to be investigated, we provide evidence that AD-MSCs, a less invasive and highly available source of MSCs, exert an important therapeutic effect in this pathology.

scholarly journals Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma

2012 ◽  
Vol 19 (8) ◽  
pp. 572-578 ◽  
Author(s):  
H Kosaka ◽  
T Ichikawa ◽  
K Kurozumi ◽  
H Kambara ◽  
S Inoue ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Suicide Gene

scholarly journals Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression

Theranostics ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 2690-2703 ◽  
Author(s):  
Amit Shwartz ◽  
Oshra Betzer ◽  
Noam Kronfeld ◽  
Gila Kazimirsky ◽  
Simona Cazacu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Glutamate Transporter

scholarly journals Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis

2014 ◽  
Vol 46 (8) ◽  
pp. e110-e110 ◽  
Author(s):  
Myung-Deok Kim ◽  
Sung-Soo Kim ◽  
Hyun-Young Cha ◽  
Seung-Hun Jang ◽  
Da-Young Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Hepatocyte Growth
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